Detailed information    

insolico Bioinformatically predicted

Overview

Name   comE/blpR   Type   Regulator
Locus tag   NYE32_RS02535 Genome accession   NZ_CP150201
Coordinates   505068..505811 (-) Length   247 a.a.
NCBI ID   WP_008534015.1    Uniprot ID   A0A6N3DKQ4
Organism   Streptococcus sp. FSL R7-0248     
Function   activate transcription of early competence genes; regulation of comX expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 500068..510811
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  NYE32_RS02515 (NYE32_02515) rplJ 501200..501703 (+) 504 WP_003095623.1 50S ribosomal protein L10 -
  NYE32_RS02520 (NYE32_02520) rplL 501778..502146 (+) 369 WP_004183006.1 50S ribosomal protein L7/L12 -
  NYE32_RS02525 (NYE32_02525) - 502945..503511 (+) 567 WP_008534013.1 hypothetical protein -
  NYE32_RS02530 (NYE32_02530) - 503751..505058 (-) 1308 WP_008534014.1 GHKL domain-containing protein -
  NYE32_RS02535 (NYE32_02535) comE/blpR 505068..505811 (-) 744 WP_008534015.1 response regulator transcription factor Regulator
  NYE32_RS02540 (NYE32_02540) - 506758..507015 (+) 258 Protein_452 type II toxin-antitoxin system Phd/YefM family antitoxin -
  NYE32_RS02545 (NYE32_02545) - 507388..507597 (+) 210 Protein_453 CHAP domain-containing protein -
  NYE32_RS02550 (NYE32_02550) - 507655..508248 (+) 594 WP_008534021.1 type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein -
  NYE32_RS02555 (NYE32_02555) - 508476..510029 (+) 1554 WP_037608729.1 BCCT family transporter -
  NYE32_RS02560 (NYE32_02560) - 510039..510191 (+) 153 Protein_456 LysR family transcriptional regulator -

Sequence

Protein


Download         Length: 247 a.a.        Molecular weight: 28780.17 Da        Isoelectric Point: 5.9343

>NTDB_id=966159 NYE32_RS02535 WP_008534015.1 505068..505811(-) (comE/blpR) [Streptococcus sp. FSL R7-0248]
MLNIFILEDEFLQQTRIETVIKDVIAKKSLKCKGPEIFGKPSQLLDEITERGSHQLFFLDIEIKGEEKKGLDIAKEIRKK
DPNATIVFVTTHSEFMPVTFKYRVAALDFIDKALDDEDFYERVHLAIEYTMDKMGATIAQDSFTFETATAHVQVPFNNIL
FFETSPTIHKVILHTKEERMEFYASISEVERADDRLFRCHRSFIVNPENIVRINKEEKMVMFENNNECPISRTKYKGLLE
KVKSLKS

Nucleotide


Download         Length: 744 bp        

>NTDB_id=966159 NYE32_RS02535 WP_008534015.1 505068..505811(-) (comE/blpR) [Streptococcus sp. FSL R7-0248]
TTGTTAAATATTTTTATTTTAGAAGACGAATTTTTACAACAAACACGAATAGAGACCGTTATTAAGGATGTTATTGCAAA
AAAATCTCTAAAATGTAAAGGACCTGAGATTTTTGGAAAACCTAGCCAGCTACTTGATGAAATTACCGAAAGAGGTTCTC
ATCAACTTTTCTTTTTAGATATTGAAATTAAAGGAGAAGAAAAAAAGGGGCTAGACATTGCAAAAGAAATTCGGAAAAAA
GACCCTAATGCAACAATTGTTTTTGTAACAACACATTCAGAATTTATGCCAGTCACTTTTAAATATAGAGTTGCTGCACT
AGATTTTATTGATAAAGCTTTAGATGATGAAGATTTTTATGAACGTGTTCATTTAGCAATTGAATATACCATGGATAAAA
TGGGTGCCACTATTGCCCAAGATTCATTTACTTTTGAAACAGCTACGGCCCATGTTCAAGTGCCTTTTAACAATATCTTA
TTTTTTGAGACATCTCCAACAATACATAAAGTTATTTTGCATACTAAAGAAGAACGCATGGAGTTCTACGCCAGTATTTC
AGAAGTTGAACGAGCTGATGACCGCCTATTTCGATGCCATCGTTCATTTATCGTTAATCCTGAAAATATCGTTAGGATCA
ATAAGGAAGAAAAAATGGTCATGTTTGAAAATAATAATGAATGTCCCATTTCGCGTACGAAATATAAGGGCCTCCTAGAA
AAAGTTAAATCTCTGAAAAGCTAA

Domains

Predicted by InterproScan.

LytTr DNA-binding domain (LytTR)

(152-241)

Response regulator receiver domain (Response_reg)

(4-123)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A6N3DKQ4

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comE/blpR Streptococcus mutans UA159

53.942

97.571

0.526
  comE/comE1 Streptococcus equinus JB1

45.679

98.381

0.449
  comE/comE2 Streptococcus equinus JB1

40.244

99.595

0.401
  comE/comE2 Streptococcus gordonii strain NCTC7865

37.652

100

0.377
  comE/comE1 Streptococcus gordonii str. Challis substr. CH1

37.652

100

0.377

Multiple sequence alignment