Detailed information    

insolico Bioinformatically predicted

Overview

Name   comR   Type   Regulator
Locus tag   WJ062_RS00335 Genome accession   NZ_CP149486
Coordinates   52553..53464 (+) Length   303 a.a.
NCBI ID   WP_136119936.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain EMM113     
Function   activate transcription of comX (predicted from homology)   
Competence regulation

Genomic Context

Location: 47553..58464
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  WJ062_RS00315 (WJ062_00310) purE 48139..48630 (+) 492 WP_002987716.1 5-(carboxyamino)imidazole ribonucleotide mutase -
  WJ062_RS00320 (WJ062_00315) purK 48617..49690 (+) 1074 WP_168639781.1 5-(carboxyamino)imidazole ribonucleotide synthase -
  WJ062_RS00325 (WJ062_00320) - 49692..51110 (+) 1419 WP_109821005.1 hypothetical protein -
  WJ062_RS00330 (WJ062_00325) purB 51130..52422 (+) 1293 WP_030127622.1 adenylosuccinate lyase -
  WJ062_RS00335 (WJ062_00330) comR 52553..53464 (+) 912 WP_136119936.1 transcriptional regulator Rgg4/ComR Regulator
  WJ062_RS00340 comS 53548..53643 (+) 96 WP_198462994.1 quorum-sensing system DWW-type pheromone Regulator
  WJ062_RS00345 (WJ062_00335) ruvB 53690..54688 (+) 999 WP_002987726.1 Holliday junction branch migration DNA helicase RuvB -
  WJ062_RS00350 (WJ062_00340) - 54826..55263 (+) 438 WP_002994668.1 low molecular weight protein-tyrosine-phosphatase -
  WJ062_RS00355 (WJ062_00345) - 55286..55687 (+) 402 WP_002986671.1 MORN repeat-containing protein -
  WJ062_RS00360 (WJ062_00350) - 55684..57459 (+) 1776 WP_011284411.1 acyltransferase family protein -

Sequence

Protein


Download         Length: 303 a.a.        Molecular weight: 35800.30 Da        Isoelectric Point: 4.5285

>NTDB_id=959406 WJ062_RS00335 WP_136119936.1 52553..53464(+) (comR) [Streptococcus pyogenes strain EMM113]
MLEHFGGKVKVLRLEKRISREDLCGDESELSVRQLARIELGQSIPSLSKVIFIAKALNVSVGYLTDGADLELPKRYKELK
YRILRTPTYMDDGKLQVREEQFDEIFEDYYDKLPEEEKIIIDCLQATLDTLLSENTNFGIDLLQEYFNQIKTKVRFRQND
LILLELYLAYLDIEGMDGQYSDKIFYDSLLDNLSEQFEQFELDELFIVNKIIIDISSLSLKNNRLDNLEKAIEMSQKIMA
KIQDWNRMPILKLIEWKYFLIKQKDIIKAEQSFMKACLFAQMTADQYLENKLIQEWEKDVKSY

Nucleotide


Download         Length: 912 bp        

>NTDB_id=959406 WJ062_RS00335 WP_136119936.1 52553..53464(+) (comR) [Streptococcus pyogenes strain EMM113]
ATGTTAGAACATTTTGGTGGAAAAGTAAAAGTGTTAAGACTTGAAAAGAGGATTAGTCGCGAGGACTTGTGTGGGGATGA
GTCTGAACTTTCTGTTCGTCAATTAGCACGGATAGAACTAGGTCAATCCATACCAAGTTTAAGTAAGGTTATTTTTATTG
CAAAAGCCTTAAACGTTAGTGTCGGTTACTTAACTGATGGTGCTGATTTAGAACTACCTAAGCGTTACAAAGAATTAAAA
TACCGTATCTTAAGGACACCAACTTACATGGATGATGGAAAATTACAAGTACGAGAAGAGCAGTTTGATGAAATTTTTGA
GGATTATTATGATAAATTACCAGAGGAAGAGAAAATAATCATTGATTGTTTACAGGCAACTTTAGATACTTTATTGAGTG
AGAATACTAACTTTGGCATTGACTTACTTCAAGAATATTTTAATCAAATAAAGACTAAGGTACGCTTTAGGCAAAATGAT
TTAATACTTCTAGAATTATATTTAGCTTATCTTGATATTGAGGGAATGGATGGACAATATTCAGATAAGATTTTTTATGA
TTCTTTATTAGATAATCTATCAGAACAATTTGAACAATTTGAATTAGATGAATTATTTATAGTTAATAAGATTATCATTG
ATATTTCATCACTAAGCTTAAAAAATAACCGACTTGATAATTTAGAAAAAGCGATTGAAATGAGTCAAAAAATTATGGCG
AAAATTCAAGATTGGAATAGAATGCCTATTTTAAAACTAATAGAATGGAAATATTTTTTAATCAAACAAAAAGATATAAT
AAAAGCAGAACAATCATTTATGAAGGCATGTTTGTTCGCCCAAATGACAGCTGATCAGTATTTGGAAAACAAGTTAATTC
AAGAGTGGGAAAAAGATGTTAAAAGTTATTAA

Domains

Predicted by InterproScan.

ComR tetratricopeptide (ComR_TPR)

(73-296)

Helix-turn-helix (HTH_3)

(12-64)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comR Streptococcus pyogenes MGAS8232

99.67

100

0.997
  comR Streptococcus pyogenes MGAS315

58.14

99.34

0.578
  comR Streptococcus infantarius subsp. infantarius ATCC BAA-102

51.027

96.37

0.492
  comR Streptococcus mutans UA159

46.026

99.67

0.459