NTDB

Overview

Name	comE/blpR	Type	Regulator
Locus tag	ACIVIR_RS04485	Genome accession	NZ_CP173225
Coordinates	853093..853830 (+)	Length	245 a.a.
NCBI ID	WP_050221200.1	Uniprot ID	-
Organism	Streptococcus pneumoniae strain 262
Function	activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 848093..858830

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ACIVIR_RS04455	dnaJ	848338..849474 (+)	1137	WP_050073039.1	molecular chaperone DnaJ	-
ACIVIR_RS04460	-	849854..850141 (-)	288	WP_000777760.1	hypothetical protein	-
ACIVIR_RS04465	-	850151..850561 (-)	411	WP_001278301.1	HIT family protein	-
ACIVIR_RS04470	pptA	850629..851360 (+)	732	WP_050221198.1	ABC transporter ATP-binding protein	Regulator
ACIVIR_RS04475	pptB	851357..852406 (+)	1050	WP_050221199.1	ABC transporter permease	Regulator
ACIVIR_RS04480	-	852468..852797 (-)	330	WP_000132585.1	hypothetical protein	-
ACIVIR_RS04485	comE/blpR	853093..853830 (+)	738	WP_050221200.1	LytTR family DNA-binding domain-containing protein	Regulator
ACIVIR_RS04490	-	853844..855193 (+)	1350	WP_050221201.1	sensor histidine kinase	-
ACIVIR_RS04495	-	855427..855618 (+)	192	WP_376738204.1	hypothetical protein	-
ACIVIR_RS04500	-	855819..855983 (+)	165	WP_049511538.1	hypothetical protein	-
ACIVIR_RS04505	-	855980..856384 (+)	405	WP_050221203.1	hypothetical protein	-
ACIVIR_RS04510	-	856655..856931 (+)	277	Protein_845	immunity protein	-
ACIVIR_RS04515	-	857014..857397 (+)	384	WP_050221205.1	hypothetical protein	-
ACIVIR_RS04520	-	857462..858151 (+)	690	WP_050221206.1	CPBP family intramembrane glutamic endopeptidase	-
ACIVIR_RS04525	blpZ	858193..858441 (+)	249	WP_050221207.1	immunity protein BlpZ	-

Sequence

Protein

Download Length: 245 a.a. Molecular weight: 28828.99 Da Isoelectric Point: 6.1688

                                >NTDB_id=957240 ACIVIR_RS04485 WP_050221200.1 853093..853830(+) (comE/blpR) [Streptococcus pneumoniae strain 262]

MRIFVLEDDFSQQTRIETTIEKLLKEHQIVPSSFEVFGKPDQLLAEVHEKGAHQLFFLDIEIRNEEMKGLEVARKIRDRD

PYALIVFVTTHSEFMPLSFRYQVSALDYIDKALSAEEFESRIETALLYANSQDSKSLAEDCFYFKSKFAQFQYPFKEVYY

LETSPRAHRVILYTKTDRLEFTASLEEVFKQEPRLLQCHRSFLINPANVVRLDKKEKLLYFPNGGSCMIARYKVREVSEA

INNLH

Nucleotide

Download Length: 738 bp

                                >NTDB_id=957240 ACIVIR_RS04485 WP_050221200.1 853093..853830(+) (comE/blpR) [Streptococcus pneumoniae strain 262]

ATGAGAATATTTGTTTTAGAAGATGATTTTTCCCAACAGACTAGGATTGAAACGACGATTGAGAAACTCTTGAAAGAACA

TCAGATCGTTCCCAGCTCTTTTGAAGTTTTTGGTAAGCCAGACCAGCTGCTGGCAGAGGTGCATGAGAAGGGAGCTCATC

AGCTATTCTTTTTGGACATTGAGATTCGAAACGAGGAGATGAAGGGTCTGGAAGTGGCTAGAAAGATCCGGGATCGGGAT

CCTTATGCCTTGATAGTCTTTGTGACGACTCACTCGGAGTTTATGCCTCTGTCCTTTCGCTACCAAGTGTCTGCTCTAGA

CTACATTGATAAGGCCTTGTCAGCAGAGGAGTTTGAATCTCGGATCGAGACAGCCCTTCTCTATGCCAATAGTCAAGATA

GTAAAAGTTTGGCGGAAGATTGCTTTTACTTTAAATCAAAATTTGCCCAATTCCAGTATCCTTTTAAAGAGGTTTATTAT

CTTGAAACGTCGCCCAGAGCCCATCGTGTTATTCTCTATACCAAGACAGACAGGCTGGAATTTACAGCGAGTTTAGAGGA

GGTTTTCAAGCAGGAGCCCCGTCTCTTGCAGTGCCACCGCTCTTTTCTCATCAATCCTGCCAATGTAGTTCGTTTGGATA

AGAAAGAAAAACTTCTTTACTTTCCCAATGGTGGAAGCTGTATGATAGCGCGTTATAAGGTCAGGGAAGTGTCTGAAGCT

ATCAATAACTTACATTGA

Domains

Predicted by InterProScan.

Response regulator receiver domain (Response_reg)

(3-122)

LytTr DNA-binding domain (LytTR)

(151-241)

Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.

3D structure

Source	ID	Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.

Visualization of predicted probability:

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	H_a-value
comE/blpR	Streptococcus mutans UA159	55.144	99.184	0.547
comE/comE1	Streptococcus equinus JB1	43.46	96.735	0.42
comE/comE2	Streptococcus equinus JB1	39.669	98.776	0.392
comE	Streptococcus infantis strain Atu-4	36.179	100	0.363

Detailed information NTG0957240