Detailed information    

insolico Bioinformatically predicted

Overview

Name   comC/comC2   Type   Regulator
Locus tag   QMM33_RS10515 Genome accession   NZ_AP025940
Coordinates   2072579..2072704 (-) Length   41 a.a.
NCBI ID   WP_000799686.1    Uniprot ID   P60242
Organism   Streptococcus pneumoniae strain PZ900700204     
Function   binding to ComD; induce autophosphorylation of ComD (predicted from homology)   
Competence regulation

Genomic Context

Location: 2067579..2077704
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  QMM33_RS10485 - 2067960..2069571 (-) 1612 Protein_2033 YhgE/Pip domain-containing protein -
  QMM33_RS10490 (PC0204_20190) - 2069699..2070241 (+) 543 WP_001158263.1 TetR/AcrR family transcriptional regulator -
  QMM33_RS10505 (PC0204_20200) comE 2070484..2071236 (-) 753 WP_000866065.1 competence system response regulator transcription factor ComE Regulator
  QMM33_RS10510 (PC0204_20210) comD/comD2 2071233..2072558 (-) 1326 WP_001842237.1 competence system sensor histidine kinase ComD Regulator
  QMM33_RS10515 comC/comC2 2072579..2072704 (-) 126 WP_000799686.1 competence-stimulating peptide ComC Regulator
  QMM33_RS10525 (PC0204_20220) rlmH 2072986..2073465 (-) 480 WP_000695929.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  QMM33_RS10530 (PC0204_20230) htrA 2073648..2074829 (+) 1182 WP_000681601.1 S1C family serine protease Regulator
  QMM33_RS10535 (PC0204_20240) spo0J 2074887..2075645 (+) 759 WP_000410383.1 ParB/RepB/Spo0J family partition protein Regulator

Sequence

Protein


Download         Length: 41 a.a.        Molecular weight: 4907.00 Da        Isoelectric Point: 11.0006

>NTDB_id=95559 QMM33_RS10515 WP_000799686.1 2072579..2072704(-) (comC/comC2) [Streptococcus pneumoniae strain PZ900700204]
MKNTVKLEQFVALKEKDLQKIKGGEMRISRIILDFLFLRKK

Nucleotide


Download         Length: 126 bp        

>NTDB_id=95559 QMM33_RS10515 WP_000799686.1 2072579..2072704(-) (comC/comC2) [Streptococcus pneumoniae strain PZ900700204]
ATGAAAAACACAGTTAAATTGGAACAGTTTGTAGCTTTGAAGGAAAAAGACTTACAAAAGATTAAAGGTGGGGAGATGAG
GATTTCAAGAATCATCCTTGATTTTCTTTTCCTACGAAAAAAGTAA

Domains

Predicted by InterproScan.

COMC family (ComC)

(1-29)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  PDB 6CJ8
  PDB 6COO
  PDB 6COP
  PDB 6COQ
  PDB 6COR
  PDB 6COS
  PDB 6COW
  PDB 6OBW
  PDB 6OC2
  PDB 6OC4
  PDB 6OLD
  PDB 6V1N

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comC/comC2 Streptococcus pneumoniae A66

100

100

1
  comC/comC2 Streptococcus pneumoniae TIGR4

100

100

1
  comC/comC1 Streptococcus pneumoniae R6

80.488

100

0.805
  comC/comC1 Streptococcus pneumoniae G54

80.488

100

0.805
  comC/comC1 Streptococcus pneumoniae D39

80.488

100

0.805
  comC/comC1 Streptococcus pneumoniae Rx1

80.488

100

0.805
  comC Streptococcus mitis SK321

75.61

100

0.756
  comC Streptococcus mitis NCTC 12261

57.5

97.561

0.561

Multiple sequence alignment