Detailed information NTG0095557

Bioinformatically predicted

Overview

• Name: comE
• Type: Regulator
• Locus tag: QMM33_RS10505
• Genome accession: NZ_AP025940
• Coordinates: 2070484..2071236 (-)
• Length: 250 a.a.
• NCBI ID: WP_000866065.1
• Uniprot ID: -
• Organism: Streptococcus pneumoniae strain PZ900700204
• Function: activate transcription of early competence genes (predicted from homology) Competence regulation

Genomic Context

Location: 2065484..2076236

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
QMM33_RS10485	-	2067960..2069571 (-)	1612	Protein_2033	YhgE/Pip domain-containing protein	-
QMM33_RS10490 (PC0204_20190)	-	2069699..2070241 (+)	543	WP_001158263.1	TetR/AcrR family transcriptional regulator	-
QMM33_RS10505 (PC0204_20200)	comE	2070484..2071236 (-)	753	WP_000866065.1	competence system response regulator transcription factor ComE	Regulator
QMM33_RS10510 (PC0204_20210)	comD/comD2	2071233..2072558 (-)	1326	WP_001842237.1	competence system sensor histidine kinase ComD	Regulator
QMM33_RS10515	comC/comC2	2072579..2072704 (-)	126	WP_000799686.1	competence-stimulating peptide ComC	Regulator
QMM33_RS10525 (PC0204_20220)	rlmH	2072986..2073465 (-)	480	WP_000695929.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
QMM33_RS10530 (PC0204_20230)	htrA	2073648..2074829 (+)	1182	WP_000681601.1	S1C family serine protease	Regulator
QMM33_RS10535 (PC0204_20240)	spo0J	2074887..2075645 (+)	759	WP_000410383.1	ParB/RepB/Spo0J family partition protein	Regulator

Sequence

Protein

• Length: 250 a.a.
• Molecular weight: 29958.31 Da
• Isoelectric Point: 6.5073

>NTDB_id=95557 QMM33_RS10505 WP_000866065.1 2070484..2071236(-) (comE) [Streptococcus pneumoniae strain PZ900700204]
MKVLILEDVIEHQVRLERILDEISKESNIPISYKTTGKVREFEEYIENDEVNQLYFLDIDIHGIEKKGFEVAQLIRHYNP
YAIIVFITSRSEFATLTYKYQVSALDFVDKDINDEMFKKRIEQNIFYTKSMLLENEDVVDYFDYNYKGNDLKIPYHDILY
IETTGVSHKLRIIGKNFAKEFYGTMTDIQEKDKHTQRFYSPHKSFLVNIGNIREIDRKNLEIVFYEDHRCPISRLKIRKL
KDILEKKSQK

Nucleotide

• Length: 753 bp

>NTDB_id=95557 QMM33_RS10505 WP_000866065.1 2070484..2071236(-) (comE) [Streptococcus pneumoniae strain PZ900700204]
ATGAAAGTTTTAATTTTAGAAGATGTTATTGAACATCAAGTGAGACTAGAGAGAATATTGGATGAAATTTCGAAAGAATC
GAATATTCCAATATCATACAAGACAACGGGAAAAGTCCGTGAATTTGAAGAATACATTGAAAATGATGAAGTAAATCAGC
TTTATTTCCTAGATATCGATATTCATGGAATTGAGAAAAAGGGATTTGAAGTGGCTCAGCTCATTCGTCATTACAATCCT
TACGCTATTATCGTCTTTATCACTAGTCGATCAGAGTTTGCGACTCTAACCTATAAATACCAGGTATCAGCCCTAGATTT
TGTTGATAAGGATATCAATGATGAGATGTTTAAGAAGAGAATTGAGCAAAATATCTTCTACACGAAGAGTATGTTACTTG
AAAATGAAGATGTTGTAGATTATTTCGACTACAATTACAAGGGAAATGATTTAAAAATTCCTTACCATGATATTTTGTAT
ATTGAAACAACAGGGGTATCTCATAAATTGCGCATTATTGGTAAGAATTTTGCAAAAGAGTTTTATGGTACCATGACAGA
TATTCAGGAAAAGGACAAACATACTCAGCGATTTTATTCTCCTCACAAGTCATTTTTGGTAAATATAGGCAATATCAGAG
AAATTGATCGAAAAAACTTAGAAATTGTTTTCTATGAAGACCATCGTTGTCCTATTTCAAGATTAAAAATTAGAAAATTA
AAAGATATTTTAGAGAAAAAATCTCAAAAGTGA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (151-244)

• Response regulator receiver domain (Response_reg) (3-121)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE	Streptococcus pneumoniae Rx1	100	100	1
comE	Streptococcus pneumoniae D39	100	100	1
comE	Streptococcus pneumoniae R6	100	100	1
comE	Streptococcus pneumoniae TIGR4	100	100	1
comE	Streptococcus mitis SK321	99.2	100	0.992
comE	Streptococcus mitis NCTC 12261	98.4	100	0.984
comE	Streptococcus infantis strain Atu-4	91.2	100	0.912
comE/comE2	Streptococcus gordonii strain NCTC7865	62.8	100	0.628
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	62.8	100	0.628
comE/blpR	Streptococcus mutans UA159	41.296	98.8	0.408