Detailed information NTG0095495

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: QMM33_RS02475
• Genome accession: NZ_AP025940
• Coordinates: 480867..481604 (+)
• Length: 245 a.a.
• NCBI ID: WP_001219145.1
• Uniprot ID: -
• Organism: Streptococcus pneumoniae strain PZ900700204
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 475867..486604

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
QMM33_RS02440	-	476842..477036 (-)	195	WP_050207116.1	hypothetical protein	-
QMM33_RS02445 (PC0204_04670)	-	477198..477485 (-)	288	WP_000777760.1	hypothetical protein	-
QMM33_RS02450 (PC0204_04680)	-	477495..477905 (-)	411	WP_001278301.1	HIT family protein	-
QMM33_RS02455 (PC0204_04690)	pptA	477973..478704 (+)	732	WP_000889923.1	ABC transporter ATP-binding protein	Regulator
QMM33_RS02460 (PC0204_04700)	-	478701..479750 (+)	1050	WP_000653771.1	ABC transporter permease	-
QMM33_RS02465 (PC0204_04710)	-	479918..480247 (-)	330	WP_050207112.1	hypothetical protein	-
QMM33_RS02470 (PC0204_04720)	-	480524..480862 (+)	339	WP_050249616.1	LytTR family DNA-binding domain-containing protein	-
QMM33_RS02475 (PC0204_04730)	comE/blpR	480867..481604 (+)	738	WP_001219145.1	response regulator transcription factor	Regulator
QMM33_RS02480 (PC0204_04740)	-	481618..482958 (+)	1341	WP_050212001.1	sensor histidine kinase	-
QMM33_RS02485 (PC0204_04750)	blpC	483000..483155 (-)	156	WP_044791640.1	quorum-sensing system pheromone BlpC	-
QMM33_RS02490	-	483212..484573 (-)	1362	Protein_492	bacteriocin secretion accessory protein	-
QMM33_RS02495 (PC0204_04780)	comA/nlmT	484584..486260 (-)	1677	WP_318155894.1	peptide cleavage/export ABC transporter	Regulator

Sequence

Protein

• Length: 245 a.a.
• Molecular weight: 28798.90 Da
• Isoelectric Point: 6.0454

>NTDB_id=95495 QMM33_RS02475 WP_001219145.1 480867..481604(+) (comE/blpR) [Streptococcus pneumoniae strain PZ900700204]
MRIFVLEDDFSQQTRIETTIEKLLKEHHITPSSFEVFGKPDQLLAEVHEKGAHQLFFLDIEIRNEEMKGLEVARKIREQD
PYALIVFVTTHSEFMPLSFRYQVSALDYIDKALSAEEFESRIETALLYANSQDSKSLAEDCFYFKSKFAQFQYPFKEVYY
LETSPRPHRVILYTKTDRLEFTASLEEVFKQEPRLLQCHRSFLINPANVVHLDKKEKLLFFPNGGSCLIARYKVREVSEA
INNLH

Nucleotide

• Length: 738 bp

>NTDB_id=95495 QMM33_RS02475 WP_001219145.1 480867..481604(+) (comE/blpR) [Streptococcus pneumoniae strain PZ900700204]
ATGAGAATATTTGTTTTAGAGGATGATTTTTCCCAACAGACTAGGATTGAAACGACGATTGAGAAACTCTTGAAGGAACA
TCATATCACTCCCAGCTCTTTTGAGGTATTTGGCAAGCCAGACCAACTGCTGGCAGAGGTGCATGAGAAGGGGGCCCATC
AGCTATTCTTTTTGGATATTGAGATTCGAAATGAGGAGATGAAGGGGCTGGAAGTGGCTAGAAAGATTCGGGAACAAGAC
CCCTATGCCCTGATTGTCTTTGTGACGACTCACTCGGAGTTTATGCCCCTGTCCTTTCGCTACCAAGTGTCTGCTCTGGA
CTATATTGATAAGGCCCTTTCGGCAGAGGAGTTTGAATCTCGAATCGAGACAGCTCTCCTCTATGCCAATAGTCAAGATA
GTAAAAGTCTGGCGGAAGATTGCTTTTACTTTAAATCAAAATTTGCCCAATTTCAGTATCCTTTTAAAGAGGTTTACTAT
CTCGAAACATCCCCAAGACCCCATCGTGTTATTCTCTATACCAAGACAGACAGGCTGGAATTTACAGCGAGTTTAGAGGA
GGTTTTCAAGCAGGAACCCCGTCTCTTGCAGTGCCATCGCTCTTTTCTCATCAATCCTGCAAATGTGGTGCATTTGGATA
AGAAAGAAAAACTCCTTTTCTTTCCCAATGGTGGAAGTTGTCTGATCGCGCGTTATAAGGTCAGGGAAGTGTCTGAGGCT
ATTAATAACTTACACTGA

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (151-241)

• Response regulator receiver domain (Response_reg) (3-122)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	54.321	99.184	0.539
comE/comE1	Streptococcus equinus JB1	43.882	96.735	0.424
comE/comE2	Streptococcus equinus JB1	38.843	98.776	0.384
comE	Streptococcus infantis strain Atu-4	36.179	100	0.363