Detailed information
Bioinformatically predicted
Overview
| Name | ciaR | Type | Regulator |
| Locus tag | WDV79_RS02820 | Genome accession | NZ_CP147731 |
| Coordinates | 566365..567045 (-) | Length | 226 a.a. |
| NCBI ID | WP_000590620.1 | Uniprot ID | A0AAV3JNX7 |
| Organism | Streptococcus agalactiae strain SagR266 | ||
| Function | repress competence development; post-transcriptional repression of CSP production (predicted from homology) Competence regulation |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| ICE | 501811..586075 | 566365..567045 | within | 0 |
Gene organization within MGE regions
Location: 501811..586075
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| WDV79_RS02520 (WDV79_02520) | - | 502139..502255 (-) | 117 | WP_001791010.1 | tetracycline resistance determinant leader peptide | - |
| WDV79_RS02525 (WDV79_02525) | - | 502500..503432 (-) | 933 | WP_001224319.1 | conjugal transfer protein | - |
| WDV79_RS02530 (WDV79_02530) | - | 503429..504430 (-) | 1002 | WP_000769868.1 | bifunctional lysozyme/C40 family peptidase | - |
| WDV79_RS02535 (WDV79_02535) | - | 504427..506604 (-) | 2178 | Protein_503 | YtxH domain-containing protein | - |
| WDV79_RS02540 (WDV79_02540) | - | 506607..509054 (-) | 2448 | WP_000331160.1 | ATP-binding protein | - |
| WDV79_RS02545 (WDV79_02545) | - | 509038..509430 (-) | 393 | WP_000723888.1 | conjugal transfer protein | - |
| WDV79_RS02550 (WDV79_02550) | - | 509519..510016 (-) | 498 | WP_000342539.1 | antirestriction protein ArdA | - |
| WDV79_RS02555 (WDV79_02555) | - | 510133..510354 (-) | 222 | WP_001009056.1 | hypothetical protein | - |
| WDV79_RS02560 (WDV79_02560) | mobT | 510397..511602 (-) | 1206 | WP_000398284.1 | MobT family relaxase | - |
| WDV79_RS02565 (WDV79_02565) | - | 511625..511777 (-) | 153 | WP_000879507.1 | hypothetical protein | - |
| WDV79_RS02570 (WDV79_02570) | - | 511780..513177 (-) | 1398 | WP_319163114.1 | FtsK/SpoIIIE domain-containing protein | - |
| WDV79_RS02575 (WDV79_02575) | - | 513206..513592 (-) | 387 | WP_000985015.1 | YdcP family protein | - |
| WDV79_RS02580 (WDV79_02580) | - | 513608..513922 (-) | 315 | WP_000420682.1 | YdcP family protein | - |
| WDV79_RS02585 (WDV79_02585) | - | 514304..515086 (-) | 783 | WP_000467138.1 | hypothetical protein | - |
| WDV79_RS02590 (WDV79_02590) | - | 515098..515796 (-) | 699 | WP_000192686.1 | ABC transporter ATP-binding protein | - |
| WDV79_RS02595 (WDV79_02595) | - | 515797..516165 (-) | 369 | WP_000312256.1 | GntR family transcriptional regulator | - |
| WDV79_RS02600 (WDV79_02600) | - | 516310..519414 (+) | 3105 | WP_000457960.1 | DNA polymerase III subunit alpha | - |
| WDV79_RS02605 (WDV79_02605) | pfkA | 519495..520517 (+) | 1023 | WP_000820831.1 | 6-phosphofructokinase | - |
| WDV79_RS02610 (WDV79_02610) | pyk | 520566..522068 (+) | 1503 | WP_001042781.1 | pyruvate kinase | - |
| WDV79_RS02615 (WDV79_02615) | lepB | 522239..522796 (+) | 558 | WP_000240773.1 | signal peptidase I | - |
| WDV79_RS02620 (WDV79_02620) | glmS | 523065..524879 (+) | 1815 | WP_000334314.1 | glutamine--fructose-6-phosphate transaminase (isomerizing) | - |
| WDV79_RS02625 (WDV79_02625) | - | 525056..526189 (+) | 1134 | WP_000564846.1 | ISAs1-like element IS1548 family transposase | - |
| WDV79_RS02630 (WDV79_02630) | - | 526368..526697 (+) | 330 | WP_000056777.1 | zinc ribbon domain-containing protein YjdM | - |
| WDV79_RS02635 (WDV79_02635) | - | 526832..527473 (+) | 642 | WP_000120401.1 | amino acid ABC transporter permease | - |
| WDV79_RS02640 (WDV79_02640) | - | 527483..528112 (+) | 630 | WP_000891276.1 | amino acid ABC transporter ATP-binding protein | - |
| WDV79_RS02645 (WDV79_02645) | - | 528126..528959 (+) | 834 | WP_000955380.1 | amino acid ABC transporter substrate-binding protein | - |
| WDV79_RS02650 (WDV79_02650) | rpsT | 529043..529291 (-) | 249 | WP_001872296.1 | 30S ribosomal protein S20 | - |
| WDV79_RS02655 (WDV79_02655) | coaA | 529345..530265 (-) | 921 | WP_001058331.1 | type I pantothenate kinase | - |
| WDV79_RS02660 (WDV79_02660) | - | 530371..530961 (+) | 591 | WP_000002661.1 | class I SAM-dependent methyltransferase | - |
| WDV79_RS02665 (WDV79_02665) | - | 531287..531676 (+) | 390 | WP_000526762.1 | cytidine deaminase | - |
| WDV79_RS02670 (WDV79_02670) | - | 531741..532790 (+) | 1050 | WP_001034779.1 | BMP family protein | - |
| WDV79_RS02675 (WDV79_02675) | - | 532935..534470 (+) | 1536 | WP_000193235.1 | ABC transporter ATP-binding protein | - |
| WDV79_RS02680 (WDV79_02680) | - | 534463..535524 (+) | 1062 | WP_000036988.1 | ABC transporter permease | - |
| WDV79_RS02685 (WDV79_02685) | - | 535526..536482 (+) | 957 | WP_000060306.1 | ABC transporter permease | - |
| WDV79_RS02690 (WDV79_02690) | - | 536687..538057 (+) | 1371 | WP_000036813.1 | FAD-dependent oxidoreductase | - |
| WDV79_RS02695 (WDV79_02695) | - | 538178..539167 (-) | 990 | WP_000127487.1 | L-lactate dehydrogenase | - |
| WDV79_RS02700 (WDV79_02700) | gyrA | 539406..541865 (+) | 2460 | WP_017644318.1 | DNA gyrase subunit A | - |
| WDV79_RS02705 (WDV79_02705) | - | 541872..542615 (+) | 744 | WP_001244681.1 | class A sortase | - |
| WDV79_RS02710 (WDV79_02710) | - | 542631..543044 (+) | 414 | WP_000767937.1 | VOC family protein | - |
| WDV79_RS02715 (WDV79_02715) | - | 543197..544159 (+) | 963 | WP_000023418.1 | DUF1002 domain-containing protein | - |
| WDV79_RS02720 (WDV79_02720) | - | 544222..545349 (-) | 1128 | WP_000547446.1 | cation:proton antiporter | - |
| WDV79_RS02725 (WDV79_02725) | - | 545609..546414 (+) | 806 | WP_088181596.1 | IS5-like element IS1381A family transposase | - |
| WDV79_RS02730 (WDV79_02730) | guaA | 546480..548042 (-) | 1563 | WP_000129872.1 | glutamine-hydrolyzing GMP synthase | - |
| WDV79_RS02735 (WDV79_02735) | - | 548255..548953 (+) | 699 | WP_319163118.1 | GntR family transcriptional regulator | - |
| WDV79_RS02740 (WDV79_02740) | trmFO | 549067..550401 (+) | 1335 | WP_000083750.1 | methylenetetrahydrofolate--tRNA-(uracil(54)- C(5))-methyltransferase (FADH(2)-oxidizing) TrmFO | - |
| WDV79_RS02745 (WDV79_02745) | - | 550479..551222 (+) | 744 | WP_000559000.1 | GNAT family N-acetyltransferase | - |
| WDV79_RS02750 (WDV79_02750) | - | 551355..552203 (+) | 849 | WP_000694283.1 | MetQ/NlpA family ABC transporter substrate-binding protein | - |
| WDV79_RS02755 (WDV79_02755) | - | 552235..552724 (-) | 490 | Protein_547 | PASTA domain-containing protein | - |
| WDV79_RS02760 (WDV79_02760) | - | 552890..553852 (+) | 963 | WP_001253127.1 | S41 family peptidase | - |
| WDV79_RS02765 (WDV79_02765) | - | 553878..554630 (+) | 753 | WP_000923535.1 | ABC transporter ATP-binding protein | - |
| WDV79_RS02770 (WDV79_02770) | - | 554632..556587 (+) | 1956 | WP_000499553.1 | FtsX-like permease family protein | - |
| WDV79_RS02775 (WDV79_02775) | - | 556697..557353 (+) | 657 | WP_319163120.1 | response regulator transcription factor | - |
| WDV79_RS02780 (WDV79_02780) | - | 557350..558288 (+) | 939 | WP_000620981.1 | sensor histidine kinase | - |
| WDV79_RS02785 (WDV79_02785) | xerS | 558331..559401 (-) | 1071 | WP_000817930.1 | tyrosine recombinase XerS | - |
| WDV79_RS02790 (WDV79_02790) | - | 559854..561515 (+) | 1662 | WP_000093960.1 | peptide ABC transporter substrate-binding protein | - |
| WDV79_RS02795 (WDV79_02795) | - | 561548..562321 (-) | 774 | WP_000622398.1 | DUF3307 domain-containing protein | - |
| WDV79_RS02800 (WDV79_02800) | - | 562311..562997 (-) | 687 | WP_000280308.1 | SatD family protein | - |
| WDV79_RS02805 (WDV79_02805) | ffh | 563064..564629 (-) | 1566 | WP_000863589.1 | signal recognition particle protein | - |
| WDV79_RS02810 (WDV79_02810) | - | 564647..564979 (-) | 333 | WP_000402075.1 | putative DNA-binding protein | - |
| WDV79_RS02815 (WDV79_02815) | ciaH | 565068..566381 (-) | 1314 | WP_000042580.1 | HAMP domain-containing sensor histidine kinase | Regulator |
| WDV79_RS02820 (WDV79_02820) | ciaR | 566365..567045 (-) | 681 | WP_000590620.1 | response regulator transcription factor | Regulator |
| WDV79_RS02825 (WDV79_02825) | - | 567207..569756 (-) | 2550 | WP_000859382.1 | M1 family metallopeptidase | - |
| WDV79_RS02830 (WDV79_02830) | phoU | 569902..570555 (-) | 654 | WP_000946330.1 | phosphate signaling complex protein PhoU | - |
| WDV79_RS02835 (WDV79_02835) | pstB | 570589..571347 (-) | 759 | WP_000193363.1 | phosphate ABC transporter ATP-binding protein PstB | - |
| WDV79_RS02840 (WDV79_02840) | pstB | 571359..572162 (-) | 804 | WP_000852851.1 | phosphate ABC transporter ATP-binding protein PstB | - |
| WDV79_RS02845 (WDV79_02845) | pstA | 572174..573061 (-) | 888 | WP_000992189.1 | phosphate ABC transporter permease PstA | - |
| WDV79_RS02850 (WDV79_02850) | pstC | 573051..573968 (-) | 918 | WP_000795716.1 | phosphate ABC transporter permease subunit PstC | - |
| WDV79_RS02855 (WDV79_02855) | - | 574014..574880 (-) | 867 | WP_001873504.1 | phosphate ABC transporter substrate-binding protein PstS family protein | - |
| WDV79_RS02860 (WDV79_02860) | - | 575059..576369 (-) | 1311 | WP_000775401.1 | RsmB/NOP family class I SAM-dependent RNA methyltransferase | - |
| WDV79_RS02865 (WDV79_02865) | - | 576437..577201 (-) | 765 | WP_000338948.1 | inositol monophosphatase family protein | - |
| WDV79_RS02870 (WDV79_02870) | - | 577191..577472 (-) | 282 | WP_000625903.1 | UPF0223 family protein | - |
| WDV79_RS02875 (WDV79_02875) | - | 577465..577878 (-) | 414 | WP_000631264.1 | Spx/MgsR family RNA polymerase-binding regulatory protein | - |
| WDV79_RS02880 (WDV79_02880) | - | 577921..578853 (-) | 933 | WP_000690921.1 | bifunctional riboflavin kinase/FAD synthetase | - |
| WDV79_RS02885 (WDV79_02885) | truB | 578866..579750 (-) | 885 | WP_001873502.1 | tRNA pseudouridine(55) synthase TruB | - |
| WDV79_RS02890 (WDV79_02890) | - | 579842..580273 (-) | 432 | WP_000702703.1 | GNAT family N-acetyltransferase | - |
| WDV79_RS02895 (WDV79_02895) | - | 580286..581557 (-) | 1272 | WP_001002583.1 | DUF2130 domain-containing protein | - |
| WDV79_RS02900 (WDV79_02900) | - | 581591..582181 (-) | 591 | WP_001135934.1 | restriction endonuclease subunit S | - |
| WDV79_RS02905 (WDV79_02905) | - | 582288..583166 (-) | 879 | WP_001209260.1 | type II CAAX endopeptidase family protein | - |
| WDV79_RS02910 (WDV79_02910) | - | 583272..585902 (-) | 2631 | WP_000520616.1 | ABC transporter permease | - |
Sequence
Protein
Download Length: 226 a.a. Molecular weight: 25852.63 Da Isoelectric Point: 4.2507
>NTDB_id=948312 WDV79_RS02820 WP_000590620.1 566365..567045(-) (ciaR) [Streptococcus agalactiae strain SagR266]
MIKILLIEDDLSLSNSVFDFLDDFADVMQIFDGEEGLYEAESGVYDLILLDLMLPEKNGFQVLKELREKGITTPVLIMTA
KESIDDKGQGFDLGADDYLTKPFYLEELKMRIQALLKRSGKFNDNSLIYGDIRVDMSTNSTFVNQTEVELLGKEFDLLVY
FLQNQNVILPKSQIFDRIWGFDSDTTISVVEVYVSKVRKKLKGTLFSENLQTLRSVGYILKHVETD
MIKILLIEDDLSLSNSVFDFLDDFADVMQIFDGEEGLYEAESGVYDLILLDLMLPEKNGFQVLKELREKGITTPVLIMTA
KESIDDKGQGFDLGADDYLTKPFYLEELKMRIQALLKRSGKFNDNSLIYGDIRVDMSTNSTFVNQTEVELLGKEFDLLVY
FLQNQNVILPKSQIFDRIWGFDSDTTISVVEVYVSKVRKKLKGTLFSENLQTLRSVGYILKHVETD
Nucleotide
Download Length: 681 bp
>NTDB_id=948312 WDV79_RS02820 WP_000590620.1 566365..567045(-) (ciaR) [Streptococcus agalactiae strain SagR266]
ATGATAAAAATTTTATTAATTGAAGATGACTTGAGTCTTTCCAATTCCGTTTTTGATTTCCTTGATGACTTTGCCGATGT
CATGCAAATTTTTGATGGAGAAGAGGGTCTTTACGAAGCCGAAAGTGGAGTCTATGATCTGATTCTTCTAGATCTCATGT
TACCTGAAAAAAACGGCTTCCAAGTGTTGAAAGAGCTACGTGAAAAAGGTATTACAACCCCTGTATTAATAATGACCGCT
AAAGAAAGCATTGATGATAAGGGACAAGGTTTCGACTTAGGTGCTGATGATTATCTAACAAAACCTTTTTACCTAGAAGA
ACTAAAAATGCGAATTCAGGCTCTTTTAAAGCGTTCTGGAAAATTTAATGATAACAGCCTAATTTATGGTGATATTCGCG
TAGACATGTCTACTAACTCAACCTTTGTTAATCAAACAGAAGTTGAGCTCTTAGGTAAAGAGTTTGATCTTTTAGTCTAT
TTCCTTCAAAATCAAAATGTTATCTTACCGAAATCTCAAATCTTTGATCGTATTTGGGGATTTGATAGTGATACAACGAT
TTCAGTTGTAGAAGTCTATGTCTCTAAGGTTCGGAAAAAATTAAAAGGAACACTTTTTTCAGAAAACCTTCAAACTTTGC
GTAGTGTAGGATATATTTTAAAGCATGTCGAAACCGATTAA
ATGATAAAAATTTTATTAATTGAAGATGACTTGAGTCTTTCCAATTCCGTTTTTGATTTCCTTGATGACTTTGCCGATGT
CATGCAAATTTTTGATGGAGAAGAGGGTCTTTACGAAGCCGAAAGTGGAGTCTATGATCTGATTCTTCTAGATCTCATGT
TACCTGAAAAAAACGGCTTCCAAGTGTTGAAAGAGCTACGTGAAAAAGGTATTACAACCCCTGTATTAATAATGACCGCT
AAAGAAAGCATTGATGATAAGGGACAAGGTTTCGACTTAGGTGCTGATGATTATCTAACAAAACCTTTTTACCTAGAAGA
ACTAAAAATGCGAATTCAGGCTCTTTTAAAGCGTTCTGGAAAATTTAATGATAACAGCCTAATTTATGGTGATATTCGCG
TAGACATGTCTACTAACTCAACCTTTGTTAATCAAACAGAAGTTGAGCTCTTAGGTAAAGAGTTTGATCTTTTAGTCTAT
TTCCTTCAAAATCAAAATGTTATCTTACCGAAATCTCAAATCTTTGATCGTATTTGGGGATTTGATAGTGATACAACGAT
TTCAGTTGTAGAAGTCTATGTCTCTAAGGTTCGGAAAAAATTAAAAGGAACACTTTTTTCAGAAAACCTTCAAACTTTGC
GTAGTGTAGGATATATTTTAAAGCATGTCGAAACCGATTAA
3D structure
| Source | ID | Structure |
|---|
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| ciaR | Streptococcus pneumoniae TIGR4 |
88.393 |
99.115 |
0.876 |
| ciaR | Streptococcus pneumoniae D39 |
88.393 |
99.115 |
0.876 |
| ciaR | Streptococcus pneumoniae R6 |
88.393 |
99.115 |
0.876 |
| ciaR | Streptococcus pneumoniae Rx1 |
88.393 |
99.115 |
0.876 |
| ciaR | Streptococcus mutans UA159 |
88.688 |
97.788 |
0.867 |
| vicR | Streptococcus mutans UA159 |
35.193 |
100 |
0.363 |
| covR | Lactococcus lactis subsp. lactis strain DGCC12653 |
36.607 |
99.115 |
0.363 |