NTDB

Overview

Name	comE/blpR	Type	Regulator
Locus tag	V6U69_RS07555	Genome accession	NZ_CP145867
Coordinates	1647519..1648262 (+)	Length	247 a.a.
NCBI ID	WP_410533576.1	Uniprot ID	-
Organism	Streptococcus salivarius strain KSS10
Function	activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
Genomic island	1635948..1651103	1647519..1648262	within	0

Gene organization within MGE regions

Location: 1635948..1651103

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
V6U69_RS07505 (V6U69_07505)	-	1635948..1637243 (+)	1296	WP_080610328.1	GHKL domain-containing protein	-
V6U69_RS07510 (V6U69_07510)	-	1637409..1638110 (-)	702	WP_410533573.1	glucosamine-6-phosphate deaminase	-
V6U69_RS07515 (V6U69_07515)	queA	1638261..1639304 (+)	1044	WP_060973333.1	tRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase QueA	-
V6U69_RS07520 (V6U69_07520)	-	1639401..1641188 (-)	1788	WP_148512730.1	ABC transporter ATP-binding protein	-
V6U69_RS07525 (V6U69_07525)	-	1641201..1642937 (-)	1737	WP_073689834.1	ABC transporter ATP-binding protein	-
V6U69_RS07530 (V6U69_07530)	-	1643124..1643291 (-)	168	Protein_1469	LysR family transcriptional regulator	-
V6U69_RS07535 (V6U69_07535)	-	1643301..1644854 (-)	1554	WP_037605638.1	BCCT family transporter	-
V6U69_RS07540 (V6U69_07540)	-	1645082..1645705 (-)	624	WP_148512728.1	type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein	-
V6U69_RS07545 (V6U69_07545)	-	1645733..1645948 (-)	216	Protein_1472	CHAP domain-containing protein	-
V6U69_RS07550 (V6U69_07550)	-	1646315..1646572 (-)	258	Protein_1473	type II toxin-antitoxin system Phd/YefM family antitoxin	-
V6U69_RS07555 (V6U69_07555)	comE/blpR	1647519..1648262 (+)	744	WP_410533576.1	response regulator transcription factor	Regulator
V6U69_RS07560 (V6U69_07560)	-	1648272..1649579 (+)	1308	WP_148512726.1	sensor histidine kinase	-
V6U69_RS07565 (V6U69_07565)	-	1649759..1650409 (-)	651	WP_148512725.1	DUF6287 domain-containing protein	-
V6U69_RS07570 (V6U69_07570)	-	1650813..1651103 (+)	291	WP_037602021.1	hypothetical protein	-

Sequence

Protein

Download Length: 247 a.a. Molecular weight: 28718.16 Da Isoelectric Point: 6.1726

                                >NTDB_id=940795 V6U69_RS07555 WP_410533576.1 1647519..1648262(+) (comE/blpR) [Streptococcus salivarius strain KSS10]

MLNIFILEDEFLQQTRIETVIKDVIAKKSLKCKGPEIFGKPSQLLDAITERGSHQLFFLDIEIKGEEKKGLDIAKEIRKK

DPNATIVFVTTHSEFMPVTFKYRVAALDFIDKALDDEDFYERVHLAIEYTIDKMGATIAQDSFTFETATAHVQVPFNNIL

FFETSPTIHKVILHTKEERMEFYASISEVERADDRLYRCHRSFIVNPENIVKINKEEKMVMFENNNECPISRTKYKGLLE

KVKSLKI

Nucleotide

Download Length: 744 bp

                                >NTDB_id=940795 V6U69_RS07555 WP_410533576.1 1647519..1648262(+) (comE/blpR) [Streptococcus salivarius strain KSS10]

TTGTTAAATATTTTTATTTTAGAAGACGAATTTTTACAACAAACACGAATAGAGACCGTTATTAAGGATGTTATTGCCAA

AAAATCTCTAAAATGTAAAGGACCTGAGATTTTTGGAAAACCTAGCCAGTTACTTGACGCAATTACGGAAAGAGGTTCTC

ACCAACTTTTCTTTTTAGATATTGAAATTAAAGGAGAAGAAAAAAAGGGGCTAGACATTGCGAAAGAAATTCGAAAAAAA

GATCCTAATGCAACAATTGTTTTTGTAACAACACATTCAGAATTTATGCCAGTCACTTTTAAATATAGAGTTGCTGCACT

AGATTTTATTGATAAAGCTTTAGATGATGAAGATTTTTATGAACGTGTTCATTTAGCAATTGAATATACCATAGATAAAA

TGGGTGCCACTATTGCCCAAGATTCTTTTACTTTTGAAACAGCTACGGCCCATGTTCAAGTGCCTTTTAACAATATCTTA

TTTTTTGAAACGTCTCCAACAATACATAAAGTTATTTTGCATACTAAAGAAGAACGAATGGAGTTCTACGCCAGTATTTC

AGAAGTTGAACGAGCTGACGACCGCCTATATCGATGCCATCGTTCATTTATCGTTAATCCTGAAAATATCGTTAAGATCA

ATAAAGAAGAGAAAATGGTAATGTTTGAAAATAATAATGAATGTCCCATTTCCCGTACGAAATATAAGGGTCTCCTAGAA

AAAGTTAAATCTTTGAAAATCTAA

Domains

Predicted by InterproScan.

LytTr DNA-binding domain (LytTR)

(152-241)

Response regulator receiver domain (Response_reg)

(4-123)

Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.

3D structure

Source	ID	Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.

Visualization of predicted probability:

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	H_a-value
comE/blpR	Streptococcus mutans UA159	53.112	97.571	0.518
comE/comE1	Streptococcus equinus JB1	45.679	98.381	0.449
comE/comE2	Streptococcus equinus JB1	39.431	99.595	0.393
comE/comE2	Streptococcus gordonii strain NCTC7865	37.247	100	0.372
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	37.247	100	0.372

Detailed information NTG0940795