Detailed information    

insolico Bioinformatically predicted

Overview

Name   mecA   Type   Regulator
Locus tag   V6U64_RS09280 Genome accession   NZ_CP145862
Coordinates   2009942..2010691 (-) Length   249 a.a.
NCBI ID   WP_021143484.1    Uniprot ID   A0A074IYL9
Organism   Streptococcus salivarius strain KSS4     
Function   degradation of ComX (predicted from homology)   
Competence regulation

Genomic Context

Location: 2004942..2015691
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  V6U64_RS09260 (V6U64_09265) - 2005264..2006496 (-) 1233 WP_002886438.1 cysteine desulfurase -
  V6U64_RS09265 (V6U64_09270) sufD 2006550..2007812 (-) 1263 WP_175057380.1 Fe-S cluster assembly protein SufD -
  V6U64_RS09270 (V6U64_09275) sufC 2007849..2008619 (-) 771 WP_002883600.1 Fe-S cluster assembly ATPase SufC -
  V6U64_RS09275 (V6U64_09280) - 2008781..2009938 (-) 1158 WP_002883603.1 glycosyltransferase family 4 protein -
  V6U64_RS09280 (V6U64_09285) mecA 2009942..2010691 (-) 750 WP_021143484.1 adaptor protein MecA Regulator
  V6U64_RS09285 (V6U64_09290) - 2010898..2011269 (+) 372 WP_002889766.1 DUF3021 family protein -
  V6U64_RS09290 (V6U64_09295) - 2011329..2012183 (-) 855 WP_002883622.1 undecaprenyl-diphosphate phosphatase -
  V6U64_RS09295 (V6U64_09300) - 2012389..2013936 (+) 1548 WP_371595849.1 ABC transporter substrate-binding protein/permease -
  V6U64_RS09300 (V6U64_09305) - 2013936..2014676 (+) 741 WP_002886432.1 amino acid ABC transporter ATP-binding protein -
  V6U64_RS09305 (V6U64_09310) - 2014751..2015521 (-) 771 WP_038675188.1 membrane protein -

Sequence

Protein


Download         Length: 249 a.a.        Molecular weight: 29086.66 Da        Isoelectric Point: 4.0182

>NTDB_id=940474 V6U64_RS09280 WP_021143484.1 2009942..2010691(-) (mecA) [Streptococcus salivarius strain KSS4]
MEMKQISETTLKIMITMEDLEEHGMELKDFLIPQEKTEEFFYTVMDELDLPDNFKNSGMLSFRVTPRKDRVDVFVTKSDL
KEDLDFNDLSDMDDYSGLSPEEFLKALEGNFMDKGDIEAHHKLEELEKTLEEVDKAMTEPTKEVAEENIREDYTHYVLAF
SDFDQVVTFTQGLKDVPVEGSELYKLGDVYYMTILLYLADEPDYYANNMYARFLEYANVADRTRAYLQEHATILMEEDAL
PVLQATKWS

Nucleotide


Download         Length: 750 bp        

>NTDB_id=940474 V6U64_RS09280 WP_021143484.1 2009942..2010691(-) (mecA) [Streptococcus salivarius strain KSS4]
ATGGAAATGAAACAAATAAGCGAGACAACTCTAAAAATCATGATTACCATGGAAGATCTTGAAGAACATGGTATGGAATT
GAAGGATTTCTTGATTCCCCAGGAAAAAACAGAGGAATTTTTCTATACTGTCATGGATGAGTTGGACTTGCCTGATAACT
TTAAAAATAGTGGGATGCTGAGCTTCCGTGTCACGCCACGCAAGGATCGTGTGGATGTCTTTGTGACTAAATCAGATCTT
AAGGAAGACCTTGATTTCAACGATTTGTCAGATATGGATGACTACTCAGGGCTTTCTCCAGAAGAGTTCCTCAAGGCTCT
TGAGGGTAACTTTATGGACAAGGGTGACATCGAAGCACACCATAAGCTCGAAGAGCTTGAAAAGACCTTGGAAGAGGTTG
ATAAGGCTATGACAGAGCCTACCAAGGAAGTGGCTGAAGAAAATATTCGTGAAGACTATACCCACTATGTCTTGGCCTTC
TCTGACTTTGATCAAGTGGTGACCTTTACACAAGGCTTGAAGGATGTGCCTGTTGAAGGTTCTGAGCTTTATAAACTTGG
GGATGTCTACTATATGACAATCCTTCTTTACTTGGCTGATGAGCCTGATTATTACGCGAACAATATGTATGCGCGTTTTC
TTGAATATGCGAATGTGGCAGACCGAACACGTGCCTACCTACAAGAGCATGCAACAATCTTGATGGAAGAGGACGCCTTA
CCGGTACTACAAGCAACGAAATGGAGCTAA

Domains

Predicted by InterproScan.

Negative regulator of genetic competence (MecA) (MecA)

(1-242)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A074IYL9

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  mecA Streptococcus thermophilus LMD-9

94.378

100

0.944
  mecA Streptococcus thermophilus LMG 18311

93.574

100

0.936
  mecA Streptococcus mutans UA159

60.246

97.992

0.59
  mecA Streptococcus pneumoniae Rx1

47.39

100

0.474
  mecA Streptococcus pneumoniae D39

47.39

100

0.474
  mecA Streptococcus pneumoniae R6

47.39

100

0.474
  mecA Streptococcus pneumoniae TIGR4

47.39

100

0.474