Detailed information    

insolico Bioinformatically predicted

Overview

Name   mecA   Type   Regulator
Locus tag   V6U63_RS00925 Genome accession   NZ_CP145861
Coordinates   165158..165907 (+) Length   249 a.a.
NCBI ID   WP_021143484.1    Uniprot ID   A0A074IYL9
Organism   Streptococcus salivarius strain KSS3     
Function   degradation of ComX (predicted from homology)   
Competence regulation

Genomic Context

Location: 160158..170907
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  V6U63_RS00900 (V6U63_00900) - 160328..161098 (+) 771 WP_410535144.1 hypothetical protein -
  V6U63_RS00905 (V6U63_00905) - 161173..161913 (-) 741 WP_002886432.1 amino acid ABC transporter ATP-binding protein -
  V6U63_RS00910 (V6U63_00910) - 161913..163460 (-) 1548 WP_156685181.1 ABC transporter substrate-binding protein/permease -
  V6U63_RS00915 (V6U63_00915) - 163666..164520 (+) 855 WP_002883622.1 undecaprenyl-diphosphate phosphatase -
  V6U63_RS00920 (V6U63_00920) - 164580..164951 (-) 372 WP_073689825.1 DUF3021 family protein -
  V6U63_RS00925 (V6U63_00925) mecA 165158..165907 (+) 750 WP_021143484.1 adaptor protein MecA Regulator
  V6U63_RS00930 (V6U63_00930) - 165911..167068 (+) 1158 WP_195914727.1 glycosyltransferase family 4 protein -
  V6U63_RS00935 (V6U63_00935) sufC 167230..168000 (+) 771 WP_002883600.1 Fe-S cluster assembly ATPase SufC -
  V6U63_RS00940 (V6U63_00940) sufD 168037..169299 (+) 1263 WP_148513097.1 Fe-S cluster assembly protein SufD -
  V6U63_RS00945 (V6U63_00945) - 169353..170585 (+) 1233 WP_410535147.1 cysteine desulfurase -

Sequence

Protein


Download         Length: 249 a.a.        Molecular weight: 29086.66 Da        Isoelectric Point: 4.0182

>NTDB_id=940353 V6U63_RS00925 WP_021143484.1 165158..165907(+) (mecA) [Streptococcus salivarius strain KSS3]
MEMKQISETTLKIMITMEDLEEHGMELKDFLIPQEKTEEFFYTVMDELDLPDNFKNSGMLSFRVTPRKDRVDVFVTKSDL
KEDLDFNDLSDMDDYSGLSPEEFLKALEGNFMDKGDIEAHHKLEELEKTLEEVDKAMTEPTKEVAEENIREDYTHYVLAF
SDFDQVVTFTQGLKDVPVEGSELYKLGDVYYMTILLYLADEPDYYANNMYARFLEYANVADRTRAYLQEHATILMEEDAL
PVLQATKWS

Nucleotide


Download         Length: 750 bp        

>NTDB_id=940353 V6U63_RS00925 WP_021143484.1 165158..165907(+) (mecA) [Streptococcus salivarius strain KSS3]
ATGGAAATGAAACAAATAAGCGAGACAACTCTAAAAATCATGATTACCATGGAAGATCTTGAAGAACATGGTATGGAATT
GAAGGATTTCTTGATTCCCCAGGAAAAAACAGAGGAATTTTTCTATACTGTCATGGATGAGTTGGACTTGCCTGATAACT
TTAAAAATAGTGGGATGCTGAGCTTCCGTGTCACGCCACGCAAGGATCGTGTGGATGTCTTTGTGACTAAATCAGATCTT
AAGGAAGACCTTGATTTCAACGATTTGTCAGATATGGATGACTACTCAGGGCTTTCTCCAGAAGAGTTCCTCAAGGCTCT
TGAGGGTAACTTTATGGACAAGGGTGACATCGAAGCACACCATAAGCTCGAAGAGCTTGAAAAGACCTTGGAAGAGGTTG
ATAAGGCTATGACAGAGCCTACCAAGGAAGTGGCTGAAGAAAATATTCGTGAAGACTATACCCACTATGTCTTGGCCTTC
TCTGACTTTGATCAAGTGGTGACTTTTACGCAAGGTTTGAAGGATGTGCCTGTTGAAGGTTCTGAGCTTTATAAGCTGGG
GGATGTCTACTACATGACGATTCTTCTTTACTTGGCTGATGAGCCTGATTATTACGCGAACAATATGTATGCGCGTTTTC
TTGAATATGCGAATGTGGCAGACCGAACACGTGCCTACCTACAAGAGCATGCAACAATCTTGATGGAAGAGGACGCCTTA
CCGGTACTACAAGCAACGAAATGGAGCTAA

Domains

Predicted by InterproScan.

Negative regulator of genetic competence (MecA) (MecA)

(1-242)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A074IYL9

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  mecA Streptococcus thermophilus LMD-9

94.378

100

0.944
  mecA Streptococcus thermophilus LMG 18311

93.574

100

0.936
  mecA Streptococcus mutans UA159

60.246

97.992

0.59
  mecA Streptococcus pneumoniae Rx1

47.39

100

0.474
  mecA Streptococcus pneumoniae D39

47.39

100

0.474
  mecA Streptococcus pneumoniae R6

47.39

100

0.474
  mecA Streptococcus pneumoniae TIGR4

47.39

100

0.474