Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   V4S37_RS02125 Genome accession   NZ_CP144502
Coordinates   398420..399667 (-) Length   415 a.a.
NCBI ID   WP_047242863.1    Uniprot ID   A0A1Y4QZA2
Organism   Enterococcus cecorum strain 45     
Function   require for competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 393420..404667
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  V4S37_RS02090 (V4S37_02090) - 394508..394732 (+) 225 WP_281957233.1 hypothetical protein -
  V4S37_RS02095 (V4S37_02095) - 394732..394890 (+) 159 WP_016250930.1 hypothetical protein -
  V4S37_RS02100 (V4S37_02100) - 394949..395338 (+) 390 WP_016250931.1 phage holin family protein -
  V4S37_RS02105 (V4S37_02105) - 395335..396144 (+) 810 WP_347900132.1 N-acetylmuramoyl-L-alanine amidase -
  V4S37_RS02110 (V4S37_02110) - 396173..396556 (-) 384 WP_047338835.1 type II toxin-antitoxin system PemK/MazF family toxin -
  V4S37_RS02115 (V4S37_02115) - 396553..397071 (-) 519 WP_047338836.1 type II toxin-antitoxin system antitoxin SocA domain-containing protein -
  V4S37_RS02120 (V4S37_02120) - 397657..398313 (+) 657 WP_047242864.1 Crp/Fnr family transcriptional regulator -
  V4S37_RS02125 (V4S37_02125) htrA 398420..399667 (-) 1248 WP_047242863.1 trypsin-like peptidase domain-containing protein Regulator
  V4S37_RS02130 (V4S37_02130) rlmH 400124..400603 (+) 480 WP_016251475.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  V4S37_RS02135 (V4S37_02135) - 400611..401309 (+) 699 WP_016251476.1 hypothetical protein -
  V4S37_RS02140 (V4S37_02140) - 401457..402635 (+) 1179 WP_047242862.1 MalY/PatB family protein -
  V4S37_RS02145 (V4S37_02145) - 402662..403762 (+) 1101 WP_047242861.1 aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme -
  V4S37_RS02150 (V4S37_02150) - 403765..404514 (+) 750 WP_047242860.1 NADPH-dependent oxidoreductase -

Sequence

Protein


Download         Length: 415 a.a.        Molecular weight: 43061.03 Da        Isoelectric Point: 5.2387

>NTDB_id=934139 V4S37_RS02125 WP_047242863.1 398420..399667(-) (htrA) [Enterococcus cecorum strain 45]
MSRRKNSNTIMKRFGIGICSGVIGGALAFGGLYAVTGMNNATSSTGIQSAQTATKVKNVKYNVESDVTKAVSKVQGAVVS
IINLQNQNAQGTGSLEDFFGAQQGNSSSQNSGTLETASEGSGVIYKKEGKHAYIVTNNHVVEGQNALQVLLADGTKVDAE
LVGTDSYTDLAVIKIASDKVSTVATFGDSDSLKVGEPAIAIGSPLGTDYANSVTEGIISSLNRQVVSENDSGQEVNINAI
QTDAAINPGNSGGPLINIAGQVIGINSSKIATTSTSSSGVSVEGMGFAIPSNDVVNIINQLEQSGKVTRPALGVRTVDLN
ALSDQQKTNILKVPASLNEGVVLAQVNSATPAEKAGLKQYDVITEIDGEKVNDGTALRAALYKKQVGDSIKVTYYRGNDK
KTTTVHLTVDQSINE

Nucleotide


Download         Length: 1248 bp        

>NTDB_id=934139 V4S37_RS02125 WP_047242863.1 398420..399667(-) (htrA) [Enterococcus cecorum strain 45]
ATGAGTAGAAGAAAAAATTCAAATACAATTATGAAAAGATTTGGTATCGGCATTTGTAGCGGTGTGATTGGTGGTGCCCT
TGCTTTTGGTGGCTTGTATGCAGTCACAGGTATGAATAATGCGACTAGCTCAACAGGTATTCAAAGTGCCCAAACCGCAA
CTAAAGTTAAAAATGTGAAATATAATGTAGAAAGCGATGTTACAAAAGCGGTCTCTAAAGTACAAGGCGCAGTCGTTTCC
ATCATTAATTTACAAAATCAAAACGCACAAGGCACGGGCAGCTTAGAAGATTTCTTTGGTGCCCAACAAGGAAATAGTAG
CAGTCAAAATAGCGGTACTTTGGAAACAGCCAGTGAAGGTAGTGGTGTCATTTATAAAAAAGAAGGTAAACATGCTTATA
TCGTGACAAATAATCACGTGGTTGAAGGTCAAAATGCATTACAAGTCTTACTAGCAGACGGTACCAAAGTCGATGCTGAA
TTAGTTGGTACGGACAGCTATACTGACTTAGCGGTAATCAAGATTGCTAGCGATAAAGTTTCAACGGTTGCTACTTTTGG
AGATTCAGATAGTCTAAAAGTTGGTGAACCTGCCATCGCCATCGGATCACCATTAGGAACTGATTATGCCAACTCAGTGA
CTGAAGGAATTATTTCTTCTTTAAATCGTCAAGTCGTGAGTGAAAATGATTCCGGTCAAGAAGTCAATATCAATGCCATC
CAAACTGATGCAGCGATTAACCCTGGTAACTCTGGTGGTCCATTAATTAATATCGCCGGTCAAGTTATCGGAATTAACTC
AAGTAAAATTGCTACCACTTCAACCTCAAGCTCTGGTGTAAGTGTTGAAGGTATGGGCTTTGCAATTCCAAGTAATGATG
TCGTCAATATTATTAACCAACTAGAACAAAGTGGGAAAGTGACTCGTCCTGCTTTAGGGGTTAGAACGGTTGATTTGAAT
GCTTTATCTGATCAACAAAAAACAAACATCTTAAAAGTACCTGCCTCATTAAATGAAGGTGTCGTGCTTGCTCAAGTCAA
TAGTGCAACGCCTGCAGAAAAAGCTGGCTTGAAACAATATGATGTTATTACTGAAATTGATGGCGAAAAGGTCAACGATG
GCACTGCTTTAAGAGCGGCTCTTTATAAAAAACAAGTCGGTGACAGCATTAAAGTGACTTACTATCGTGGCAATGACAAA
AAGACAACCACCGTACACCTTACCGTCGACCAATCAATTAATGAATAA

Domains

Predicted by InterproScan.

Trypsin-like peptidase domain (Trypsin_2)

(120-265)

PDZ domain (PDZ_2)

(310-407)

Peptidase family M50 (Peptidase_M50)

(251-410)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A1Y4QZA2

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus mutans UA159

56.461

85.783

0.484
  htrA Streptococcus gordonii str. Challis substr. CH1

49.14

98.072

0.482
  htrA Streptococcus pneumoniae R6

48.529

98.313

0.477
  htrA Streptococcus pneumoniae TIGR4

48.529

98.313

0.477
  htrA Streptococcus pneumoniae D39

48.529

98.313

0.477
  htrA Streptococcus pneumoniae Rx1

48.529

98.313

0.477
  htrA Streptococcus mitis NCTC 12261

50.131

91.807

0.46