Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   V4S29_RS11135 Genome accession   NZ_CP144498
Coordinates   2196344..2197591 (+) Length   415 a.a.
NCBI ID   WP_208922427.1    Uniprot ID   -
Organism   Enterococcus cecorum strain 66     
Function   require for competence development (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
ICE 2176032..2228905 2196344..2197591 within 0


Gene organization within MGE regions


Location: 2176032..2228905
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  V4S29_RS11030 (V4S29_11035) - 2176200..2176643 (-) 444 WP_047242846.1 ComGF family competence protein -
  V4S29_RS11035 (V4S29_11040) - 2176636..2176902 (-) 267 WP_171336299.1 hypothetical protein -
  V4S29_RS11040 (V4S29_11045) - 2176877..2177257 (-) 381 WP_240185464.1 hypothetical protein -
  V4S29_RS11045 (V4S29_11050) - 2177310..2177612 (-) 303 WP_171315373.1 prepilin-type N-terminal cleavage/methylation domain-containing protein -
  V4S29_RS11050 (V4S29_11055) comGB 2177627..2178637 (-) 1011 WP_171315399.1 competence type IV pilus assembly protein ComGB -
  V4S29_RS11055 (V4S29_11060) comGA 2178624..2179547 (-) 924 WP_347905543.1 competence type IV pilus ATPase ComGA -
  V4S29_RS11060 (V4S29_11065) - 2179700..2180971 (-) 1272 WP_114975656.1 O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase family protein -
  V4S29_RS11065 (V4S29_11070) - 2181068..2181781 (-) 714 WP_243183297.1 gamma-glutamyl-gamma-aminobutyrate hydrolase family protein -
  V4S29_RS11070 (V4S29_11075) - 2181850..2183358 (-) 1509 WP_243174400.1 zinc ABC transporter substrate-binding protein AdcA -
  V4S29_RS11075 (V4S29_11080) menA 2183524..2184468 (-) 945 WP_208922430.1 1,4-dihydroxy-2-naphthoate polyprenyltransferase -
  V4S29_RS11080 (V4S29_11085) - 2184487..2185536 (-) 1050 WP_016251485.1 FAD:protein FMN transferase -
  V4S29_RS11085 (V4S29_11090) pplA 2185737..2186672 (-) 936 WP_171336301.1 extracellular electron transfer flavoprotein PplA -
  V4S29_RS11090 (V4S29_11095) - 2186941..2188887 (+) 1947 WP_171299575.1 NAD(P)/FAD-dependent oxidoreductase -
  V4S29_RS11095 (V4S29_11100) - 2189008..2189427 (+) 420 WP_113827405.1 NusG domain II-containing protein -
  V4S29_RS11100 (V4S29_11105) - 2189440..2190021 (+) 582 WP_168930763.1 Gx transporter family protein -
  V4S29_RS11105 (V4S29_11110) - 2190022..2191008 (+) 987 WP_168930761.1 polyprenyl synthetase family protein -
  V4S29_RS11110 (V4S29_11115) - 2191497..2192246 (-) 750 WP_191465208.1 NADPH-dependent oxidoreductase -
  V4S29_RS11115 (V4S29_11120) - 2192249..2193349 (-) 1101 WP_243171260.1 aminotransferase class I/II-fold pyridoxal phosphate-dependent enzyme -
  V4S29_RS11120 (V4S29_11125) - 2193375..2194553 (-) 1179 WP_243171261.1 MalY/PatB family protein -
  V4S29_RS11125 (V4S29_11130) - 2194701..2195399 (-) 699 WP_171299580.1 hydrolase -
  V4S29_RS11130 (V4S29_11135) rlmH 2195407..2195886 (-) 480 WP_016251475.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  V4S29_RS11135 (V4S29_11140) htrA 2196344..2197591 (+) 1248 WP_208922427.1 trypsin-like peptidase domain-containing protein Regulator
  V4S29_RS11140 (V4S29_11145) - 2197832..2198488 (-) 657 WP_047242864.1 Crp/Fnr family transcriptional regulator -
  V4S29_RS11145 (V4S29_11150) - 2198858..2200087 (+) 1230 WP_087403230.1 MFS transporter -
  V4S29_RS11150 (V4S29_11155) - 2200090..2200260 (+) 171 WP_171311431.1 hypothetical protein -
  V4S29_RS11155 (V4S29_11160) ytpR 2200327..2200938 (-) 612 WP_171299583.1 YtpR family tRNA-binding protein -
  V4S29_RS11160 (V4S29_11165) - 2201018..2201623 (-) 606 WP_171299595.1 CadD family cadmium resistance transporter -
  V4S29_RS11165 (V4S29_11170) - 2201665..2202108 (-) 444 WP_243171647.1 universal stress protein -
  V4S29_RS11170 (V4S29_11175) - 2202131..2202442 (-) 312 WP_171299585.1 thioredoxin family protein -
  V4S29_RS11175 (V4S29_11180) pepA 2202455..2203531 (-) 1077 WP_243171645.1 glutamyl aminopeptidase -
  V4S29_RS11180 (V4S29_11185) - 2204003..2205361 (-) 1359 WP_347905544.1 ISLre2 family transposase -
  V4S29_RS11185 (V4S29_11190) - 2205393..2205647 (-) 255 WP_347905545.1 hypothetical protein -
  V4S29_RS11190 (V4S29_11195) - 2205849..2206277 (-) 429 WP_347905546.1 single-stranded DNA-binding protein -
  V4S29_RS11195 (V4S29_11200) - 2206512..2207324 (-) 813 WP_347905547.1 ParA family protein -
  V4S29_RS11200 (V4S29_11205) - 2207363..2207572 (-) 210 WP_347905548.1 hypothetical protein -
  V4S29_RS11205 (V4S29_11210) - 2207831..2208109 (-) 279 WP_347905549.1 hypothetical protein -
  V4S29_RS11210 (V4S29_11215) - 2208113..2208571 (-) 459 WP_347905550.1 hypothetical protein -
  V4S29_RS11215 (V4S29_11220) - 2208564..2209160 (-) 597 WP_347905551.1 recombinase family protein -
  V4S29_RS11220 (V4S29_11225) - 2209243..2209482 (-) 240 WP_248622135.1 hypothetical protein -
  V4S29_RS11225 (V4S29_11230) ssb 2209553..2210017 (-) 465 WP_347905552.1 single-stranded DNA-binding protein Machinery gene
  V4S29_RS11230 (V4S29_11235) - 2210682..2211536 (-) 855 WP_347905553.1 ArdC-like ssDNA-binding domain-containing protein -
  V4S29_RS11235 (V4S29_11240) - 2212148..2213020 (-) 873 WP_347905554.1 hypothetical protein -
  V4S29_RS11240 (V4S29_11245) - 2213094..2213570 (-) 477 WP_171332717.1 hypothetical protein -
  V4S29_RS11245 (V4S29_11250) - 2213881..2214180 (-) 300 WP_347905555.1 hypothetical protein -
  V4S29_RS11250 (V4S29_11255) - 2214239..2214685 (-) 447 WP_347905556.1 JAB domain-containing protein -
  V4S29_RS11255 (V4S29_11260) - 2215491..2215616 (+) 126 WP_281957817.1 hypothetical protein -
  V4S29_RS11260 (V4S29_11265) - 2215809..2216612 (-) 804 WP_171332720.1 hypothetical protein -
  V4S29_RS11265 (V4S29_11270) - 2216653..2217498 (-) 846 WP_171332721.1 winged helix-turn-helix domain-containing protein -
  V4S29_RS11270 (V4S29_11275) - 2218335..2220545 (-) 2211 WP_347905557.1 helicase HerA-like domain-containing protein -
  V4S29_RS11275 (V4S29_11280) - 2220549..2222990 (-) 2442 WP_347905558.1 hypothetical protein -
  V4S29_RS11280 (V4S29_11285) - 2223002..2225491 (-) 2490 WP_347905559.1 ATP-binding protein -
  V4S29_RS11285 (V4S29_11290) - 2225765..2226085 (-) 321 WP_248621975.1 hypothetical protein -
  V4S29_RS11290 (V4S29_11295) - 2226236..2226622 (-) 387 WP_248621976.1 hypothetical protein -
  V4S29_RS11295 (V4S29_11300) - 2226876..2227094 (-) 219 WP_248621977.1 hypothetical protein -
  V4S29_RS11300 (V4S29_11305) - 2227188..2227400 (-) 213 WP_248621978.1 hypothetical protein -
  V4S29_RS11305 (V4S29_11310) - 2227489..2227881 (-) 393 WP_347905560.1 TcpE family conjugal transfer membrane protein -
  V4S29_RS11310 (V4S29_11315) - 2227871..2228158 (-) 288 WP_248621979.1 hypothetical protein -

Sequence

Protein


Download         Length: 415 a.a.        Molecular weight: 43263.28 Da        Isoelectric Point: 5.7751

>NTDB_id=934127 V4S29_RS11135 WP_208922427.1 2196344..2197591(+) (htrA) [Enterococcus cecorum strain 66]
MSRRKNSNTIMKRFGIGICSGVIGGALAFGGLYAVTGMNHTTSSTGIQSAQTATKVKNVKYNVESDVTKAVSKVQGAVVS
IINLQNQNAQGTGSLEDFFGAQQGNSSSQNSGTLETASEGSGVIYKKEGKYAYIVTNNHVVEGQNALQVLLADGTKVDAE
LVGTDSYTDLAVIKIASDKVSTVATFGDSDNLKVGEPAIAIGSPLGTDYANSVTEGIISSLNRQVVSENDSGQEVNINAI
QTDAAINPGNSGGPLINIAGQVIGINSSKIATTSTSSSGVSVEGMGFAIPSNDVVNIINQLEQSGKVTRPALGVRTVDLN
ALSDQQKTNILKVPTSLNEGVVLAQVNSATPAEKAGLKQYDVITEIDGKKVNDGTELRAALYKKHVGDSIKVTYYRGNDK
KTTTVHLTVDQSINE

Nucleotide


Download         Length: 1248 bp        

>NTDB_id=934127 V4S29_RS11135 WP_208922427.1 2196344..2197591(+) (htrA) [Enterococcus cecorum strain 66]
ATGAGTAGAAGAAAAAATTCAAATACAATTATGAAAAGATTTGGTATCGGCATTTGTAGCGGTGTGATTGGTGGTGCTCT
TGCTTTTGGCGGCTTGTATGCAGTCACTGGAATGAATCATACGACTAGCTCAACAGGTATTCAAAGTGCACAAACAGCAA
CTAAAGTTAAAAATGTGAAATATAATGTAGAAAGCGACGTAACAAAAGCGGTCTCTAAAGTACAAGGTGCAGTCGTTTCA
ATCATTAATTTACAAAATCAAAACGCACAAGGCACGGGCAGTTTAGAAGATTTCTTTGGTGCCCAACAAGGAAATAGTAG
CAGTCAAAATAGCGGTACTTTGGAAACAGCCAGTGAAGGTAGTGGCGTCATTTATAAAAAAGAAGGTAAATATGCTTATA
TCGTGACAAATAATCACGTGGTTGAAGGTCAAAATGCATTACAAGTCTTACTAGCAGACGGTACCAAAGTCGATGCTGAA
TTAGTTGGTACGGACAGCTATACTGACTTAGCGGTAATCAAGATTGCTAGCGATAAAGTTTCAACGGTTGCTACTTTTGG
CGATTCAGATAATCTAAAAGTTGGTGAACCTGCCATCGCCATCGGATCACCATTAGGAACCGATTATGCCAACTCAGTGA
CTGAAGGAATTATTTCTTCTTTAAATCGTCAAGTCGTGAGTGAAAATGATTCCGGCCAAGAAGTTAATATCAACGCTATC
CAAACTGATGCAGCGATTAACCCTGGTAACTCTGGTGGTCCATTAATTAATATCGCCGGTCAAGTTATCGGAATTAACTC
AAGTAAAATTGCTACCACTTCAACCTCAAGCTCTGGTGTAAGTGTTGAAGGTATGGGCTTTGCAATTCCAAGTAATGATG
TCGTCAATATTATTAACCAACTAGAACAAAGTGGGAAAGTGACTCGTCCTGCTTTAGGGGTTAGAACGGTTGATTTGAAT
GCTTTATCTGATCAACAAAAAACGAACATCTTAAAAGTACCTACCTCATTAAATGAAGGGGTCGTGCTTGCTCAAGTCAA
CAGTGCAACGCCTGCAGAAAAAGCGGGCTTGAAACAATATGATGTCATTACTGAAATTGATGGTAAAAAGGTCAATGATG
GCACTGAATTAAGAGCCGCTCTTTATAAAAAACATGTCGGTGACAGCATTAAAGTGACTTACTATCGTGGCAATGACAAA
AAGACAACCACCGTACACCTTACCGTCGACCAATCAATTAATGAATAA

Domains

Predicted by InterproScan.

Peptidase family M50 (Peptidase_M50)

(251-410)

PDZ domain (PDZ_2)

(310-407)

Trypsin-like peptidase domain (Trypsin_2)

(120-265)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus mutans UA159

56.742

85.783

0.487
  htrA Streptococcus pneumoniae Rx1

48.775

98.313

0.48
  htrA Streptococcus pneumoniae D39

48.775

98.313

0.48
  htrA Streptococcus pneumoniae R6

48.775

98.313

0.48
  htrA Streptococcus pneumoniae TIGR4

48.775

98.313

0.48
  htrA Streptococcus gordonii str. Challis substr. CH1

48.894

98.072

0.48
  htrA Streptococcus mitis NCTC 12261

50.394

91.807

0.463