Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   RG835_RS05290 Genome accession   NZ_CP144273
Coordinates   769468..770757 (+) Length   429 a.a.
NCBI ID   WP_002319485.1    Uniprot ID   -
Organism   Enterococcus faecium strain SRR12-v1     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 764468..775757
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  RG835_RS05265 (RG835_05265) - 765417..766388 (-) 972 WP_010729506.1 LacI family DNA-binding transcriptional regulator -
  RG835_RS05270 (RG835_05270) - 766526..766741 (-) 216 Protein_728 transposase -
  RG835_RS05275 (RG835_05275) - 767069..767748 (+) 680 WP_172594866.1 IS6-like element IS1216 family transposase -
  RG835_RS05280 (RG835_05280) - 767799..768434 (-) 636 Protein_730 IS30 family transposase -
  RG835_RS05285 (RG835_05285) rlmH 768560..769039 (-) 480 WP_002287841.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  RG835_RS05290 (RG835_05290) htrA 769468..770757 (+) 1290 WP_002319485.1 trypsin-like peptidase domain-containing protein Regulator
  RG835_RS05295 (RG835_05295) ytpR 770796..771401 (-) 606 WP_002294153.1 YtpR family tRNA-binding protein -
  RG835_RS05300 (RG835_05300) - 771608..772072 (-) 465 WP_002292633.1 universal stress protein -
  RG835_RS05305 (RG835_05305) - 772094..772414 (-) 321 WP_077149131.1 thioredoxin family protein -
  RG835_RS05310 (RG835_05310) pepA 772557..773636 (-) 1080 WP_002294156.1 glutamyl aminopeptidase -
  RG835_RS05315 (RG835_05315) - 773836..774186 (+) 351 WP_002289862.1 PepSY domain-containing protein -
  RG835_RS05320 (RG835_05320) - 774371..775324 (+) 954 WP_002299300.1 glycosyltransferase family 2 protein -

Sequence

Protein


Download         Length: 429 a.a.        Molecular weight: 44898.89 Da        Isoelectric Point: 4.5419

>NTDB_id=933191 RG835_RS05290 WP_002319485.1 769468..770757(+) (htrA) [Enterococcus faecium strain SRR12-v1]
MDRKNVTPKMKKNKNNSLWRKLGLGLVGGIVGGLLTAGIFYAAMGTGNNSSTATSGNQNSAGETVVENVKVNVDSDITKA
VDKVQDAVVSVINLQSQNQSSGFGGLFGQQEESSSSDDSNLEAYSEGSGVIYKKDGNTAYVVTNNHVVDGQQGLEVLMKD
GTKVKAELVGTDAYSDLAVLKINSDKVETVASFGDSSALKVGEPAIAIGSPLGSEYANSVTSGIISSLNRQVTSTNESNE
TVNINAIQTDAAINPGNSGGPLVNIEGQVIGINSSKIASTSESTSNVSVEGMGFAIPSNDVVNIINQLEKDGKVTRPALG
ITMVDLSAVSTQQQEQILKIPSSVTNGVIVTNVQTATPAEKAGLKQYDVITKIDDKEVSSGVELQSALYKKKVGDSVKIT
YYEGSKEKTTTVELTIDQSALKQNQNSEN

Nucleotide


Download         Length: 1290 bp        

>NTDB_id=933191 RG835_RS05290 WP_002319485.1 769468..770757(+) (htrA) [Enterococcus faecium strain SRR12-v1]
ATGGATAGAAAAAATGTGACACCAAAGATGAAAAAAAATAAAAATAATAGCCTCTGGCGTAAGTTAGGTCTGGGGCTTGT
TGGAGGGATCGTTGGAGGACTACTGACAGCTGGCATTTTTTATGCAGCGATGGGCACTGGCAACAATAGTTCTACTGCTA
CAAGCGGCAATCAGAATTCTGCCGGTGAAACAGTTGTGGAAAATGTCAAAGTCAATGTAGATTCTGATATCACCAAAGCG
GTAGATAAAGTTCAAGACGCTGTCGTTTCTGTTATCAACTTACAAAGTCAAAACCAATCAAGCGGTTTTGGCGGACTATT
CGGGCAGCAAGAAGAAAGTAGCAGCTCAGATGATAGTAATTTGGAAGCTTATAGTGAAGGAAGCGGCGTGATCTACAAAA
AAGACGGGAATACTGCTTATGTAGTCACGAATAATCACGTAGTAGATGGCCAGCAAGGTCTTGAAGTCTTGATGAAAGAC
GGTACGAAGGTAAAAGCTGAATTAGTTGGAACAGATGCTTATTCAGATTTAGCGGTGTTGAAGATCAATTCAGACAAAGT
CGAAACAGTTGCCTCTTTTGGTGACTCAAGTGCTCTGAAGGTTGGTGAGCCTGCGATTGCGATTGGTTCCCCACTAGGAT
CTGAATATGCAAATTCTGTCACTTCAGGAATCATTTCTTCCTTGAACCGACAAGTGACAAGTACGAATGAATCGAACGAA
ACAGTCAATATCAATGCGATCCAAACAGATGCAGCAATCAACCCTGGAAATTCTGGTGGTCCTTTAGTTAATATCGAAGG
ACAAGTTATCGGTATCAACTCAAGTAAGATCGCAAGTACTTCTGAATCTACTTCTAATGTAAGCGTAGAAGGAATGGGAT
TTGCTATTCCAAGTAACGATGTAGTGAATATCATCAATCAACTGGAAAAAGACGGAAAAGTGACACGTCCAGCTCTAGGT
ATCACAATGGTCGACTTATCTGCCGTTTCTACTCAGCAACAAGAACAAATCTTGAAGATTCCTTCATCTGTAACTAACGG
TGTCATCGTGACAAATGTCCAAACAGCTACACCGGCTGAAAAAGCTGGATTGAAACAATACGACGTCATTACTAAGATCG
ATGACAAAGAAGTTTCTTCTGGTGTAGAACTTCAATCTGCTTTGTATAAGAAAAAAGTGGGAGATTCTGTCAAAATCACT
TACTATGAAGGCTCGAAAGAAAAAACAACTACTGTTGAATTGACGATCGATCAATCGGCATTAAAACAAAATCAAAATAG
TGAAAATTAA

Domains

Predicted by InterproScan.

Peptidase family M50 (Peptidase_M50)

(10-417)

PDZ domain (PDZ_2)

(317-414)

Trypsin-like peptidase domain (Trypsin_2)

(127-272)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus gordonii str. Challis substr. CH1

54.569

91.841

0.501
  htrA Streptococcus mutans UA159

59.887

82.517

0.494
  htrA Streptococcus mitis NCTC 12261

52.778

92.308

0.487
  htrA Streptococcus pneumoniae TIGR4

59.05

78.555

0.464
  htrA Streptococcus pneumoniae Rx1

59.05

78.555

0.464
  htrA Streptococcus pneumoniae D39

59.05

78.555

0.464
  htrA Streptococcus pneumoniae R6

59.05

78.555

0.464