Detailed information NTG0925189

Bioinformatically predicted

Overview

• Name: comR
• Type: Regulator
• Locus tag: VKP53_RS00345
• Genome accession: NZ_CP142354
• Coordinates: 53406..54317 (+)
• Length: 303 a.a.
• NCBI ID: WP_002986681.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain 6745-99
• Function: activate transcription of comX (predicted from homology) Competence regulation

Genomic Context

Location: 48406..59317

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
VKP53_RS00310 (VKP53_00310)	purE	48569..49060 (+)	492	WP_032460539.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
VKP53_RS00315 (VKP53_00315)	purK	49047..50120 (+)	1074	WP_168391516.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
VKP53_RS00320 (VKP53_00320)	-	50121..50669 (+)	549	WP_228631688.1	hypothetical protein	-
VKP53_RS00325 (VKP53_00325)	-	50680..51048 (+)	369	WP_228631690.1	hypothetical protein	-
VKP53_RS00330 (VKP53_00330)	-	51051..51620 (+)	570	WP_032460531.1	hypothetical protein	-
VKP53_RS00335 (VKP53_00335)	-	51807..51986 (+)	180	WP_032460530.1	hypothetical protein	-
VKP53_RS00340 (VKP53_00340)	purB	51983..53275 (+)	1293	WP_326674817.1	adenylosuccinate lyase	-
VKP53_RS00345 (VKP53_00345)	comR	53406..54317 (+)	912	WP_002986681.1	transcriptional regulator Rgg4/ComR	Regulator
VKP53_RS09030	comS	54401..54496 (+)	96	WP_198462994.1	quorum-sensing system DWW-type pheromone	Regulator
VKP53_RS00350 (VKP53_00350)	ruvB	54543..55541 (+)	999	WP_002986679.1	Holliday junction branch migration DNA helicase RuvB	-
VKP53_RS00355 (VKP53_00355)	-	55679..56116 (+)	438	WP_002994668.1	low molecular weight protein-tyrosine-phosphatase	-
VKP53_RS00360 (VKP53_00360)	-	56139..56540 (+)	402	WP_032460528.1	MORN repeat-containing protein	-
VKP53_RS00365 (VKP53_00365)	-	56537..58312 (+)	1776	WP_032460527.1	acyltransferase family protein	-

Sequence

Protein

• Length: 303 a.a.
• Molecular weight: 35757.27 Da
• Isoelectric Point: 4.4858

>NTDB_id=925189 VKP53_RS00345 WP_002986681.1 53406..54317(+) (comR) [Streptococcus pyogenes strain 6745-99]
MLEHFGGKVKVLRLEKRISREDLCGDESELSVRQLARIELGQSIPSLSKVIFIAKALNVSVGYLTDGADLELPKRYKELK
YLILRTPTYMDDGKLQVREEQFDEIFEDYYDKLPEEEKIIIDCLQATLDTLLSENTNFGIDLLQEYFNQIKTKVRFRQND
LILLELYLAYLDIEGMDGQYSDKIFYDSLLDNLSEQFEQFELDELFIVNKIIIDISSLSLKNNRLDNLEKAIEMSQKIMA
KIQDWNRMPILKLIEWKYFLIKQKDIIKAEQSFMKACLFAQMTADQYLENKLIQEWEKDVKSY

Nucleotide

• Length: 912 bp

>NTDB_id=925189 VKP53_RS00345 WP_002986681.1 53406..54317(+) (comR) [Streptococcus pyogenes strain 6745-99]
ATGTTAGAACATTTTGGTGGAAAAGTAAAAGTGTTAAGACTTGAAAAGAGGATTAGTCGCGAGGACTTGTGTGGGGATGA
GTCTGAACTTTCTGTTCGTCAATTAGCACGGATAGAACTAGGTCAATCCATACCAAGTTTAAGTAAGGTTATTTTTATTG
CAAAAGCCTTAAACGTTAGTGTCGGTTACTTAACTGATGGTGCTGATTTAGAACTACCTAAGCGTTACAAAGAATTAAAA
TACCTTATCTTAAGGACACCAACTTACATGGATGATGGAAAATTACAAGTACGAGAAGAGCAGTTTGATGAAATTTTTGA
GGATTATTATGATAAATTACCAGAGGAAGAGAAAATAATCATTGATTGTTTACAGGCAACTTTAGATACTTTATTGAGTG
AGAATACTAACTTTGGCATTGACTTACTTCAAGAATATTTTAATCAAATAAAGACTAAGGTACGCTTTAGGCAAAATGAT
TTAATACTTCTAGAATTATATTTAGCTTATCTTGATATTGAGGGAATGGATGGACAATATTCAGATAAGATTTTTTATGA
TTCTTTATTAGATAATCTATCAGAACAATTTGAACAATTTGAATTAGATGAATTATTTATAGTTAATAAGATTATCATTG
ATATTTCATCACTAAGCTTAAAAAATAACCGACTTGATAATTTAGAAAAAGCGATTGAAATGAGTCAAAAAATTATGGCG
AAAATTCAAGATTGGAATAGAATGCCTATTTTAAAACTAATAGAATGGAAATATTTTTTAATCAAACAAAAAGATATAAT
AAAAGCAGAACAATCATTTATGAAGGCATGTTTGTTCGCCCAAATGACAGCTGATCAGTATTTGGAAAACAAGTTAATTC
AAGAGTGGGAAAAAGATGTTAAAAGTTATTAA

Domains

Predicted by InterproScan.

• Helix-turn-helix (HTH_3) (12-64)

• ComR tetratricopeptide (ComR_TPR) (73-296)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comR	Streptococcus pyogenes MGAS8232	100	100	1
comR	Streptococcus pyogenes MGAS315	58.472	99.34	0.581
comR	Streptococcus infantarius subsp. infantarius ATCC BAA-102	51.37	96.37	0.495
comR	Streptococcus mutans UA159	46.358	99.67	0.462