Detailed information NTG0925133

Bioinformatically predicted

Overview

• Name: comR
• Type: Regulator
• Locus tag: VKP39_RS00330
• Genome accession: NZ_CP142353
• Coordinates: 53363..54274 (+)
• Length: 303 a.a.
• NCBI ID: WP_014635220.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain D641
• Function: activate transcription of comX (predicted from homology) Competence regulation

Genomic Context

Location: 48363..59274

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
VKP39_RS00310 (VKP39_00310)	purE	48656..49147 (+)	492	WP_326623871.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
VKP39_RS00315 (VKP39_00315)	purK	49134..50207 (+)	1074	WP_002987718.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
VKP39_RS00320 (VKP39_00320)	-	50228..51568 (+)	1341	WP_002987721.1	hypothetical protein	-
VKP39_RS00325 (VKP39_00325)	purB	51937..53229 (+)	1293	WP_109828845.1	adenylosuccinate lyase	-
VKP39_RS00330 (VKP39_00330)	comR	53363..54274 (+)	912	WP_014635220.1	helix-turn-helix domain-containing protein	Regulator
VKP39_RS00335 (VKP39_00335)	comS	54365..54463 (+)	99	WP_020833188.1	quorum-sensing system DWW-type pheromone	Regulator
VKP39_RS00340 (VKP39_00340)	ruvB	54494..55492 (+)	999	WP_002986679.1	Holliday junction branch migration DNA helicase RuvB	-
VKP39_RS00345 (VKP39_00345)	-	55630..56067 (+)	438	WP_002994668.1	low molecular weight protein-tyrosine-phosphatase	-
VKP39_RS00350 (VKP39_00350)	-	56090..56491 (+)	402	WP_012560369.1	MORN repeat-containing protein	-
VKP39_RS00355 (VKP39_00355)	-	56488..58263 (+)	1776	WP_021733211.1	acyltransferase family protein	-

Sequence

Protein

• Length: 303 a.a.
• Molecular weight: 35925.63 Da
• Isoelectric Point: 4.9349

>NTDB_id=925133 VKP39_RS00330 WP_014635220.1 53363..54274(+) (comR) [Streptococcus pyogenes strain D641]
MLEHFGGKVKVLRLEKRISREDLCGDESELSVRQLARIELGQSIPSLSKVIFIAKALNVSVGYLTDGADLELPKRYKELK
YLILRTPTYMDDGKLQVREEQFDEIFEDYYDKLPEEEKVAVDIIQAKFEVYQTGDINFGYSILKEFLPQLKRKSIYNLNE
LLLIDLYLIILVVSHFSDDIFDVQFYEEITESMLKQHNNLPLEDLFLLNNILLSCADTYIRLKMFGRLKETLQLSHFIMS
TIQDFQKMPMYCMYEWKLSIFYLKDINRARNYFEQSILFTQMTGDTYLVQKLRGEWNKDIHYI

Nucleotide

• Length: 912 bp

>NTDB_id=925133 VKP39_RS00330 WP_014635220.1 53363..54274(+) (comR) [Streptococcus pyogenes strain D641]
ATGTTAGAACATTTTGGTGGAAAAGTAAAAGTGTTAAGACTTGAAAAGAGGATTAGTCGCGAGGACTTGTGTGGGGATGA
GTCTGAACTTTCTGTTCGTCAATTAGCACGGATAGAACTAGGTCAATCCATACCAAGTTTAAGTAAGGTTATTTTTATTG
CAAAAGCCTTAAACGTTAGTGTCGGTTACTTAACTGATGGTGCTGATTTAGAACTACCTAAGCGTTACAAAGAATTAAAA
TACCTTATCTTAAGGACACCAACTTACATGGATGATGGAAAATTACAAGTACGAGAAGAGCAGTTTGATGAAATTTTTGA
GGATTATTATGATAAATTACCAGAGGAAGAGAAAGTTGCTGTTGATATTATCCAAGCAAAATTTGAAGTTTATCAAACCG
GAGATATTAATTTCGGATATAGTATTTTAAAAGAATTTCTACCACAGCTAAAAAGAAAATCTATCTATAATTTAAATGAA
TTATTACTTATAGATTTGTATTTGATTATTCTGGTAGTTTCTCATTTTTCAGATGATATATTTGATGTACAGTTTTATGA
AGAAATAACAGAGAGCATGTTAAAACAACACAATAATTTACCATTGGAAGATTTATTTTTACTGAATAATATCTTATTAT
CTTGTGCGGACACTTATATTCGTTTGAAGATGTTCGGTCGTCTAAAAGAAACATTACAACTTAGCCACTTTATAATGTCA
ACTATTCAAGATTTTCAAAAAATGCCTATGTATTGTATGTATGAATGGAAGCTATCTATTTTTTATTTGAAAGATATTAA
CCGAGCACGGAATTACTTTGAACAGTCTATTTTATTTACTCAAATGACAGGAGATACATATTTAGTTCAAAAATTACGGG
GAGAATGGAATAAAGATATTCATTATATTTAA

Domains

Predicted by InterproScan.

• Helix-turn-helix (HTH_3) (12-64)

• ComR tetratricopeptide (ComR_TPR) (73-296)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comR	Streptococcus pyogenes MGAS315	99.34	100	0.993
comR	Streptococcus pyogenes MGAS8232	58.472	99.34	0.581
comR	Streptococcus mutans UA159	47.492	98.68	0.469
comR	Streptococcus infantarius subsp. infantarius ATCC BAA-102	46.441	97.36	0.452
comR	Streptococcus suis P1/7	37.374	98.02	0.366
comR	Streptococcus suis 05ZYH33	37.374	98.02	0.366