Detailed information NTG0925022

Bioinformatically predicted

Overview

• Name: comR
• Type: Regulator
• Locus tag: VKP55_RS00575
• Genome accession: NZ_CP142351
• Coordinates: 93070..93981 (+)
• Length: 303 a.a.
• NCBI ID: WP_326674266.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain SS1366
• Function: activate transcription of comX (predicted from homology) Competence regulation

Genomic Context

Location: 88070..98981

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
VKP55_RS00555 (VKP55_00555)	purE	88654..89145 (+)	492	WP_030127619.1	5-(carboxyamino)imidazole ribonucleotide mutase	-
VKP55_RS00560 (VKP55_00560)	purK	89132..90205 (+)	1074	WP_032461293.1	5-(carboxyamino)imidazole ribonucleotide synthase	-
VKP55_RS00565 (VKP55_00565)	-	90207..91625 (+)	1419	WP_109821005.1	hypothetical protein	-
VKP55_RS00570 (VKP55_00570)	purB	91645..92937 (+)	1293	WP_002986683.1	adenylosuccinate lyase	-
VKP55_RS00575 (VKP55_00575)	comR	93070..93981 (+)	912	WP_326674266.1	helix-turn-helix domain-containing protein	Regulator
VKP55_RS00580 (VKP55_00580)	comS	94072..94170 (+)	99	WP_020833188.1	quorum-sensing system DWW-type pheromone	Regulator
VKP55_RS00585 (VKP55_00585)	ruvB	94201..95199 (+)	999	WP_063629365.1	Holliday junction branch migration DNA helicase RuvB	-
VKP55_RS00590 (VKP55_00590)	-	95337..95774 (+)	438	WP_002994668.1	low molecular weight protein-tyrosine-phosphatase	-
VKP55_RS00595 (VKP55_00595)	-	95797..96198 (+)	402	WP_002986671.1	MORN repeat-containing protein	-
VKP55_RS00600 (VKP55_00600)	-	96195..97970 (+)	1776	WP_002987732.1	acyltransferase family protein	-

Sequence

Protein

• Length: 303 a.a.
• Molecular weight: 35883.55 Da
• Isoelectric Point: 5.0354

>NTDB_id=925022 VKP55_RS00575 WP_326674266.1 93070..93981(+) (comR) [Streptococcus pyogenes strain SS1366]
MLEHFGGKVKVLRLEKRISREDLCGDESELSVRQLARIELGQSIPSLSKVIFIAKALNVSVGYLTDGADLELPKRYKELK
YLILRTPTYMDDGKLQVREEQFDEIFEDYYDKLPEEEKVAVDIIQAKFEVYQTGDINFGYSILKEFLPQLKRKSIYNLNE
LLLIDLYLIILVVSHFSDDIFDVQVYEEITESMLKQHNNLSLEDLFLLNNILLSCADTYIRLKMFGRLKETLQLSHFRMS
TIQDFQKMPMYCMYEWKLSIFYLKDISRARNYFEQSILFTQMTGDTYLVQKLRGEWNKDIHYI

Nucleotide

• Length: 912 bp

>NTDB_id=925022 VKP55_RS00575 WP_326674266.1 93070..93981(+) (comR) [Streptococcus pyogenes strain SS1366]
ATGTTAGAACATTTTGGTGGAAAAGTAAAAGTGTTAAGACTTGAAAAGAGGATTAGTCGCGAGGACTTGTGTGGGGATGA
GTCTGAACTTTCTGTTCGTCAATTAGCACGGATAGAACTAGGTCAATCCATACCAAGTTTAAGTAAGGTTATTTTTATTG
CAAAAGCCTTAAACGTTAGTGTCGGTTACTTAACTGATGGTGCTGATTTAGAACTACCTAAGCGTTACAAAGAATTAAAA
TACCTTATCTTAAGGACACCAACTTACATGGATGATGGAAAATTACAAGTACGAGAAGAGCAGTTTGATGAAATTTTTGA
GGATTATTATGATAAATTACCAGAGGAAGAGAAAGTTGCTGTTGATATTATCCAAGCAAAATTTGAAGTTTATCAAACCG
GAGATATTAATTTCGGATATAGTATTTTAAAAGAATTTCTACCACAGCTAAAAAGAAAATCTATCTATAATTTAAATGAA
TTATTACTTATAGATTTGTATTTGATTATTCTGGTAGTTTCTCATTTTTCAGATGATATATTTGATGTACAGGTTTATGA
AGAAATAACAGAGAGCATGTTAAAACAACACAATAATTTATCATTGGAAGATTTATTTTTACTGAATAATATCTTATTAT
CTTGTGCGGACACTTATATTCGTTTGAAGATGTTCGGTCGTCTAAAAGAAACATTACAACTTAGCCACTTTAGAATGTCA
ACTATTCAAGATTTTCAAAAAATGCCTATGTATTGTATGTATGAATGGAAGCTATCTATTTTTTATTTGAAAGATATTAG
CCGAGCACGGAATTACTTTGAACAGTCTATTTTATTTACTCAAATGACAGGAGATACATATTTAGTTCAAAAATTACGGG
GAGAATGGAATAAAGATATTCATTATATTTAA

Domains

Predicted by InterproScan.

• Helix-turn-helix (HTH_3) (12-64)

• ComR tetratricopeptide (ComR_TPR) (73-296)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comR	Streptococcus pyogenes MGAS315	98.68	100	0.987
comR	Streptococcus pyogenes MGAS8232	58.033	100	0.584
comR	Streptococcus mutans UA159	46.823	98.68	0.462
comR	Streptococcus infantarius subsp. infantarius ATCC BAA-102	45.763	97.36	0.446