Detailed information    

insolico Bioinformatically predicted

Overview

Name   comA/nlmT   Type   Regulator
Locus tag   VRA41_RS07795 Genome accession   NZ_CP142105
Coordinates   1492645..1494798 (-) Length   717 a.a.
NCBI ID   WP_059257386.1    Uniprot ID   -
Organism   Streptococcus thermophilus strain SCB0351     
Function   transport of ComC (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
ICE 1441217..1524321 1492645..1494798 within 0


Gene organization within MGE regions


Location: 1441217..1524321
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  VRA41_RS07535 (VRA41_07535) gatA 1442483..1443949 (-) 1467 WP_002946584.1 Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatA -
  VRA41_RS07540 (VRA41_07540) gatC 1443949..1444251 (-) 303 WP_002884769.1 Asp-tRNA(Asn)/Glu-tRNA(Gln) amidotransferase subunit GatC -
  VRA41_RS07545 (VRA41_07545) - 1444391..1444645 (-) 255 WP_011226449.1 glycosyl transferase -
  VRA41_RS07550 (VRA41_07550) - 1444658..1444855 (-) 198 WP_231108739.1 glycosyltransferase -
  VRA41_RS07555 (VRA41_07555) - 1445183..1446624 (-) 1442 Protein_1445 6-phospho-beta-glucosidase -
  VRA41_RS07560 (VRA41_07560) msrA 1446777..1447286 (-) 510 WP_041827089.1 peptide-methionine (S)-S-oxide reductase MsrA -
  VRA41_RS07565 (VRA41_07565) - 1447298..1448146 (-) 849 WP_065429507.1 MetQ/NlpA family ABC transporter substrate-binding protein -
  VRA41_RS07570 (VRA41_07570) - 1448269..1448820 (-) 552 WP_002946999.1 cysteine hydrolase family protein -
  VRA41_RS07575 (VRA41_07575) codY 1448883..1449668 (-) 786 WP_002951720.1 GTP-sensing pleiotropic transcriptional regulator CodY -
  VRA41_RS07580 (VRA41_07580) - 1449928..1451142 (-) 1215 WP_011226456.1 pyridoxal phosphate-dependent aminotransferase -
  VRA41_RS07585 (VRA41_07585) - 1451497..1451949 (+) 453 WP_002946987.1 universal stress protein -
  VRA41_RS07590 (VRA41_07590) - 1452129..1452700 (+) 572 Protein_1452 IS30 family transposase -
  VRA41_RS07595 (VRA41_07595) - 1452916..1453386 (-) 471 WP_011227497.1 membrane protein -
  VRA41_RS07600 (VRA41_07600) pflA 1453592..1454392 (-) 801 WP_002946980.1 pyruvate formate-lyase-activating protein -
  VRA41_RS07605 (VRA41_07605) - 1454580..1454690 (-) 111 WP_014621906.1 LPXTG cell wall anchor domain-containing protein -
  VRA41_RS07610 (VRA41_07610) - 1455388..1456719 (-) 1332 WP_002951727.1 hemolysin family protein -
  VRA41_RS07615 (VRA41_07615) - 1456832..1457614 (+) 783 WP_011226459.1 ABC transporter ATP-binding protein -
  VRA41_RS07620 (VRA41_07620) - 1458233..1460299 (-) 2067 WP_011227498.1 cation:proton antiporter -
  VRA41_RS07625 (VRA41_07625) - 1460308..1460550 (-) 243 WP_011227499.1 hypothetical protein -
  VRA41_RS07630 (VRA41_07630) - 1460547..1461095 (-) 549 WP_004197152.1 tRNA (mnm(5)s(2)U34)-methyltransferase -
  VRA41_RS07635 (VRA41_07635) - 1461092..1462036 (-) 945 WP_011226463.1 TIGR01212 family radical SAM protein -
  VRA41_RS07640 (VRA41_07640) sepM 1462121..1463197 (-) 1077 WP_011226464.1 SepM family pheromone-processing serine protease Regulator
  VRA41_RS07645 (VRA41_07645) coaD 1463175..1463672 (-) 498 WP_011226465.1 pantetheine-phosphate adenylyltransferase -
  VRA41_RS07650 (VRA41_07650) rsmD 1463706..1464305 (-) 600 WP_011227500.1 16S rRNA (guanine(966)-N(2))-methyltransferase RsmD -
  VRA41_RS07655 (VRA41_07655) trxB 1464396..1465349 (-) 954 WP_255136104.1 thioredoxin-disulfide reductase -
  VRA41_RS07660 (VRA41_07660) - 1465382..1465606 (-) 225 WP_011226468.1 DUF4059 family protein -
  VRA41_RS07665 (VRA41_07665) - 1465821..1466564 (-) 744 WP_011226469.1 amino acid ABC transporter ATP-binding protein -
  VRA41_RS07670 (VRA41_07670) - 1466564..1467310 (-) 747 WP_095559509.1 amino acid ABC transporter permease -
  VRA41_RS07675 (VRA41_07675) - 1467699..1468526 (-) 828 WP_041827091.1 transporter substrate-binding domain-containing protein -
  VRA41_RS07680 (VRA41_07680) - 1469107..1469340 (-) 234 WP_002947030.1 hypothetical protein -
  VRA41_RS07685 (VRA41_07685) dinB 1469626..1470729 (-) 1104 WP_011227504.1 DNA polymerase IV -
  VRA41_RS07690 (VRA41_07690) pflB 1471007..1473316 (+) 2310 WP_011226473.1 formate C-acetyltransferase -
  VRA41_RS07695 (VRA41_07695) - 1473583..1474365 (+) 783 Protein_1473 carbonic anhydrase -
  VRA41_RS07700 (VRA41_07700) - 1474416..1474869 (+) 454 Protein_1474 GNAT family N-acetyltransferase -
  VRA41_RS07705 (VRA41_07705) - 1475203..1475505 (-) 303 WP_231108737.1 restriction endonuclease subunit S -
  VRA41_RS07710 (VRA41_07710) mobV 1475551..1476059 (-) 509 Protein_1476 MobV family relaxase -
  VRA41_RS07715 (VRA41_07715) - 1476539..1477133 (-) 595 Protein_1477 site-specific integrase -
  VRA41_RS07720 (VRA41_07720) - 1477221..1477907 (-) 687 WP_011227510.1 hypothetical protein -
  VRA41_RS07725 (VRA41_07725) - 1477983..1478738 (-) 756 WP_002951770.1 ABC transporter permease -
  VRA41_RS07730 (VRA41_07730) - 1478735..1479385 (-) 651 WP_022096490.1 ATP-binding cassette domain-containing protein -
  VRA41_RS07735 (VRA41_07735) - 1479587..1480543 (-) 957 WP_002951776.1 serine hydrolase domain-containing protein -
  VRA41_RS07740 (VRA41_07740) - 1480543..1481298 (-) 756 WP_011681560.1 CppA family protein -
  VRA41_RS07745 (VRA41_07745) - 1481651..1482604 (+) 954 WP_041826943.1 IS30 family transposase -
  VRA41_RS07750 (VRA41_07750) - 1482825..1483100 (+) 276 WP_224103608.1 CPBP family intramembrane glutamic endopeptidase -
  VRA41_RS07755 (VRA41_07755) gla 1483274..1484137 (-) 864 WP_002951781.1 aquaglyceroporin Gla -
  VRA41_RS07760 (VRA41_07760) - 1484258..1486525 (+) 2268 WP_011227515.1 Xaa-Pro dipeptidyl-peptidase -
  VRA41_RS07765 (VRA41_07765) - 1486968..1488358 (+) 1391 Protein_1487 IS3-like element ISSth1b family transposase -
  VRA41_RS07770 (VRA41_07770) - 1488504..1488746 (-) 243 WP_011227518.1 Blp family class II bacteriocin -
  VRA41_RS07775 (VRA41_07775) - 1488996..1489727 (+) 732 WP_002948869.1 LytR/AlgR family response regulator transcription factor -
  VRA41_RS07780 (VRA41_07780) - 1490264..1491067 (+) 804 WP_224103634.1 ATP-binding protein -
  VRA41_RS07785 (VRA41_07785) - 1491085..1491246 (-) 162 WP_011226496.1 ComC/BlpC family leader-containing pheromone/bacteriocin -
  VRA41_RS07790 (VRA41_07790) - 1491261..1492629 (-) 1369 Protein_1492 bacteriocin secretion accessory protein -
  VRA41_RS07795 (VRA41_07795) comA/nlmT 1492645..1494798 (-) 2154 WP_059257386.1 peptide cleavage/export ABC transporter Regulator
  VRA41_RS07800 (VRA41_07800) - 1495812..1497557 (-) 1746 WP_011226501.1 ABC transporter ATP-binding protein -
  VRA41_RS07805 (VRA41_07805) - 1497550..1499307 (-) 1758 WP_011226502.1 ABC transporter ATP-binding protein -
  VRA41_RS07810 (VRA41_07810) - 1499495..1499701 (-) 207 WP_002948879.1 hypothetical protein -
  VRA41_RS07815 (VRA41_07815) - 1499906..1500433 (-) 528 WP_011227521.1 VanZ family protein -
  VRA41_RS07820 (VRA41_07820) rlmN 1500435..1501604 (-) 1170 WP_011227522.1 23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN -
  VRA41_RS07825 (VRA41_07825) - 1501608..1502330 (-) 723 WP_011226505.1 YutD family protein -
  VRA41_RS07830 (VRA41_07830) - 1502385..1503740 (-) 1356 WP_011227523.1 bifunctional metallophosphatase/5'-nucleotidase -
  VRA41_RS07835 (VRA41_07835) - 1504588..1505931 (-) 1344 WP_002948888.1 DEAD/DEAH box helicase -
  VRA41_RS07840 (VRA41_07840) mraY 1506006..1507028 (-) 1023 WP_011227524.1 phospho-N-acetylmuramoyl-pentapeptide- transferase -
  VRA41_RS07845 (VRA41_07845) pbp2X 1507030..1509297 (-) 2268 WP_011226508.1 penicillin-binding protein PBP2X -
  VRA41_RS07850 (VRA41_07850) ftsL 1509301..1509621 (-) 321 WP_011226509.1 cell division protein FtsL -
  VRA41_RS07855 (VRA41_07855) rsmH 1509624..1510574 (-) 951 WP_002888254.1 16S rRNA (cytosine(1402)-N(4))-methyltransferase RsmH -
  VRA41_RS07860 (VRA41_07860) - 1510742..1511092 (-) 351 WP_011227526.1 hypothetical protein -
  VRA41_RS07865 (VRA41_07865) - 1511189..1511353 (-) 165 WP_231108736.1 hypothetical protein -
  VRA41_RS07870 (VRA41_07870) - 1511350..1511736 (-) 387 WP_041827096.1 hypothetical protein -
  VRA41_RS07875 (VRA41_07875) - 1511847..1512101 (-) 255 WP_011227529.1 Wzz/FepE/Etk N-terminal domain-containing protein -
  VRA41_RS07880 (VRA41_07880) - 1512375..1512731 (-) 357 WP_011226513.1 DUF805 domain-containing protein -
  VRA41_RS07885 (VRA41_07885) - 1512951..1513247 (-) 297 WP_231108735.1 hypothetical protein -
  VRA41_RS07890 (VRA41_07890) - 1513600..1514850 (-) 1251 WP_011226515.1 glutamate-5-semialdehyde dehydrogenase -
  VRA41_RS07895 (VRA41_07895) proB 1514852..1515655 (-) 804 WP_002948808.1 glutamate 5-kinase -
  VRA41_RS07900 (VRA41_07900) - 1515776..1517365 (-) 1590 WP_011226516.1 hypothetical protein -
  VRA41_RS07905 (VRA41_07905) - 1517368..1518100 (-) 733 Protein_1515 ABC transporter ATP-binding protein -
  VRA41_RS07910 (VRA41_07910) - 1518374..1519107 (+) 734 Protein_1516 DUF554 domain-containing protein -
  VRA41_RS07915 (VRA41_07915) addA 1519501..1523154 (-) 3654 WP_011227531.1 helicase-exonuclease AddAB subunit AddA -

Sequence

Protein


Download         Length: 717 a.a.        Molecular weight: 80569.46 Da        Isoelectric Point: 6.8330

>NTDB_id=921693 VRA41_RS07795 WP_059257386.1 1492645..1494798(-) (comA/nlmT) [Streptococcus thermophilus strain SCB0351]
MFRFRRTFVPQIDMRNCGVAALALVAKYYGSDYSLAHLRELAKTNKEGTTALGLVEAAKKIGFETRAIKAEMSLFEMEDV
PYPFIAHVNKDGKLQHYYVIYKSTKDYLIIGDPDPSVKVTKMTKERFEKEWTGVTLFMGPEPSYKPHKDKKNGLWDFLPL
IFKQRSLIANIVFASLLVTLINILGSYYLQGILDEYVPNQMKSTLGIISIGLVVTYVLQQMMTFARDYLLTILSQRLTID
VILSYIRHIFELPMSFFATRRTGEVISRFSDANSIIDALASTILSLFLDFSIVIIVGGVLLIQNSNLFKLVLCSVPIYTL
IVFAFMKPFELMNHDVMQSNAMVNSAIIEDINGIETIKSLTSEEVCYQKIDGEFVDYLDNSFRLSKLSILQTSLKQGAQL
ILNVLILWTGAQLVMGNTISIGQLITFNMLLSYFTNPLENIINLQTKLQSAKVANTRLNEVYLIESEFGQSDDTYQEGIA
DGDITVTDLSYKYGFGRDTLTDVSLTIRQGEKISFVGVSGSGKTTLAKMLVNFYQPYKGHIDFNGQNISRIDKKTLRQHI
NYLPQQSYIFSGSVLENLTLGAARGITQADILKACEIAEIRQDIENMPMGFQTELSDGAGLSGGQKQRIALARALLTKSP
VLILDEATSGLDVLTEKQVIDNLLALKDKTIIFVAHRLSIAERTDRIVVIDQGRVVETGSHQDLMSYPGFYYQLFRK

Nucleotide


Download         Length: 2154 bp        

>NTDB_id=921693 VRA41_RS07795 WP_059257386.1 1492645..1494798(-) (comA/nlmT) [Streptococcus thermophilus strain SCB0351]
ATGTTTCGTTTTCGTAGGACTTTTGTCCCTCAAATAGACATGAGGAATTGTGGAGTTGCTGCCTTGGCATTAGTGGCCAA
GTACTATGGTTCAGATTATTCATTAGCACATCTGCGTGAGTTGGCGAAGACCAATAAAGAAGGGACAACTGCCTTAGGTC
TTGTAGAGGCTGCTAAAAAAATTGGCTTTGAAACGAGAGCTATAAAGGCTGAAATGTCGCTCTTTGAGATGGAAGATGTT
CCTTATCCTTTTATTGCTCATGTTAATAAAGATGGGAAGCTTCAACATTATTATGTTATTTATAAAAGCACCAAGGATTA
TCTGATAATTGGAGACCCTGATCCAAGTGTAAAAGTAACTAAAATGACTAAAGAGCGTTTTGAGAAAGAGTGGACAGGTG
TTACTCTTTTTATGGGACCGGAACCCAGTTATAAACCACATAAGGATAAGAAAAATGGACTCTGGGACTTTCTCCCTTTG
ATCTTTAAACAAAGGTCCTTGATAGCTAATATTGTCTTTGCCAGTCTCTTGGTTACTTTAATAAATATTTTAGGTTCCTA
TTATTTACAAGGTATTCTAGACGAATATGTCCCTAATCAAATGAAGTCTACCTTAGGAATTATCTCAATTGGATTAGTTG
TGACCTATGTTTTACAACAAATGATGACTTTTGCAAGAGATTATCTCTTAACCATACTGAGTCAGCGATTGACCATTGAC
GTTATCTTGTCCTACATACGACATATCTTTGAACTCCCAATGTCTTTTTTTGCCACAAGACGTACAGGGGAGGTTATCTC
ACGTTTTAGTGATGCTAACTCTATTATCGATGCTCTGGCTTCGACGATATTATCACTTTTCCTTGATTTCTCTATTGTGA
TTATCGTAGGAGGCGTGTTATTGATACAAAATAGCAATCTCTTCAAGCTAGTTCTTTGTTCGGTTCCAATTTATACCCTT
ATCGTCTTTGCCTTTATGAAACCTTTTGAGCTAATGAATCATGACGTCATGCAGAGTAATGCTATGGTTAATTCAGCCAT
CATTGAGGACATTAATGGGATTGAAACCATAAAGTCACTAACCAGCGAAGAAGTATGCTATCAAAAGATTGATGGTGAGT
TTGTTGACTATCTAGACAATTCTTTTCGCCTTTCTAAGTTATCTATACTACAAACATCATTGAAACAAGGTGCTCAACTT
ATTTTAAATGTACTTATCCTCTGGACAGGTGCTCAGTTGGTGATGGGAAATACCATTTCGATAGGACAATTGATTACTTT
TAATATGTTGCTTTCTTACTTCACGAATCCTTTGGAAAATATCATTAACCTGCAAACCAAGTTACAGTCTGCTAAGGTAG
CTAATACTAGGCTCAATGAGGTCTATCTGATTGAATCAGAGTTTGGACAAAGTGATGATACCTATCAAGAAGGCATTGCG
GATGGAGATATCACTGTTACGGATTTATCTTATAAATATGGTTTTGGTCGTGATACTTTGACTGATGTCAGTTTGACGAT
TAGACAAGGAGAAAAAATCAGTTTTGTTGGTGTCAGTGGATCTGGTAAGACTACTCTAGCTAAAATGTTGGTCAATTTTT
ATCAACCATATAAGGGGCACATAGATTTTAATGGTCAAAATATTAGTCGCATAGACAAGAAAACTCTTCGTCAACATATT
AACTATCTCCCTCAGCAATCCTATATATTTAGTGGTAGTGTTTTAGAAAATCTTACTTTAGGTGCAGCACGGGGTATTAC
GCAAGCTGATATTTTGAAAGCTTGTGAAATAGCAGAAATTCGTCAAGATATTGAAAACATGCCTATGGGGTTTCAGACAG
AGCTGTCTGATGGAGCAGGTCTGTCTGGAGGGCAAAAGCAACGTATCGCTTTGGCGCGTGCACTACTAACGAAATCTCCT
GTACTAATCTTAGATGAAGCAACTAGCGGATTGGATGTTTTGACAGAAAAGCAGGTTATTGATAACCTCCTAGCACTAAA
AGATAAAACGATCATCTTTGTAGCACACAGGCTTAGTATCGCTGAGCGGACCGACCGTATCGTAGTCATTGATCAGGGAC
GCGTAGTGGAGACAGGTTCTCATCAAGACCTGATGTCTTATCCAGGTTTCTATTATCAATTATTTAGAAAGTGA

Domains

Predicted by InterproScan.

ABC transporter transmembrane region (ABC_membrane)

(170-438)

ABC transporter (ABC_tran)

(500-649)

Peptidase C39 family (Peptidase_C39)

(7-142)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comA/nlmT Streptococcus mutans UA159

67.927

99.582

0.676
  comA Streptococcus mitis NCTC 12261

66.385

99.163

0.658
  comA Streptococcus pneumoniae Rx1

65.963

99.163

0.654
  comA Streptococcus pneumoniae D39

65.963

99.163

0.654
  comA Streptococcus pneumoniae R6

65.963

99.163

0.654
  comA Streptococcus mitis SK321

65.682

99.163

0.651
  comA Streptococcus pneumoniae TIGR4

65.541

99.163

0.65
  comA Streptococcus gordonii str. Challis substr. CH1

64.286

99.582

0.64