Detailed information    

insolico Bioinformatically predicted

Overview

Name   mecA   Type   Regulator
Locus tag   VF946_RS09880 Genome accession   NZ_CP141824
Coordinates   1952044..1952766 (-) Length   240 a.a.
NCBI ID   WP_012775334.1    Uniprot ID   -
Organism   Streptococcus suis strain HB18     
Function   degradation of ComW (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
ICE 1941001..2002973 1952044..1952766 within 0


Gene organization within MGE regions


Location: 1941001..2002973
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  VF946_RS09840 oppA 1941354..1943144 (-) 1791 WP_238716838.1 oligopeptide ABC transporter substrate-binding protein Regulator
  VF946_RS09845 pbp3 1943357..1944598 (+) 1242 WP_023371474.1 D-alanyl-D-alanine carboxypeptidase PBP3 -
  VF946_RS09850 sufB 1944851..1946266 (-) 1416 WP_002938151.1 Fe-S cluster assembly protein SufB -
  VF946_RS09855 sufU 1946616..1947056 (-) 441 WP_012775691.1 Fe-S cluster assembly sulfur transfer protein SufU -
  VF946_RS09860 - 1947043..1948266 (-) 1224 WP_012027766.1 cysteine desulfurase -
  VF946_RS09865 sufD 1948270..1949532 (-) 1263 WP_012775333.1 Fe-S cluster assembly protein SufD -
  VF946_RS09870 sufC 1949549..1950322 (-) 774 WP_002938165.1 Fe-S cluster assembly ATPase SufC -
  VF946_RS09875 - 1950875..1952047 (-) 1173 WP_012027769.1 glycosyltransferase family 4 protein -
  VF946_RS09880 mecA 1952044..1952766 (-) 723 WP_012775334.1 adaptor protein MecA Regulator
  VF946_RS09885 - 1952894..1953730 (-) 837 WP_012027770.1 undecaprenyl-diphosphate phosphatase -
  VF946_RS09890 - 1953857..1955422 (+) 1566 WP_024405930.1 ABC transporter substrate-binding protein/permease -
  VF946_RS09895 - 1955415..1956158 (+) 744 WP_024389055.1 amino acid ABC transporter ATP-binding protein -
  VF946_RS09900 - 1956283..1956492 (-) 210 WP_009910800.1 hypothetical protein -
  VF946_RS09905 - 1956578..1957480 (-) 903 WP_012027774.1 SPFH domain-containing protein -
  VF946_RS09910 ilvA 1957490..1958740 (-) 1251 WP_002937416.1 threonine ammonia-lyase IlvA -
  VF946_RS09915 ilvC 1959023..1960045 (-) 1023 WP_024405928.1 ketol-acid reductoisomerase -
  VF946_RS09920 ilvN 1960186..1960662 (-) 477 WP_009910805.1 acetolactate synthase small subunit -
  VF946_RS09925 - 1960655..1962358 (-) 1704 WP_012775336.1 acetolactate synthase large subunit -
  VF946_RS09930 - 1962583..1963635 (+) 1053 WP_014917313.1 bifunctional glycosyltransferase family 2/GtrA family protein -
  VF946_RS09935 - 1963622..1964560 (+) 939 WP_012027778.1 phosphodiester glycosidase family protein -
  VF946_RS09940 - 1964535..1964951 (+) 417 WP_012775337.1 hypothetical protein -
  VF946_RS09945 ilvD 1965112..1966827 (+) 1716 WP_002937428.1 dihydroxy-acid dehydratase -
  VF946_RS09950 - 1966878..1967273 (+) 396 WP_012027779.1 DUF6176 family protein -
  VF946_RS09955 - 1967292..1967633 (-) 342 WP_012027780.1 metal-sulfur cluster assembly factor -
  VF946_RS09960 - 1967724..1968177 (-) 454 Protein_1928 pyridoxamine 5'-phosphate oxidase family protein -
  VF946_RS09965 - 1968729..1969940 (-) 1212 WP_024405914.1 PIN-like domain-containing protein -
  VF946_RS09970 - 1970143..1971015 (+) 873 WP_013851450.1 hypothetical protein -
  VF946_RS09975 - 1971030..1971500 (+) 471 WP_024405913.1 hypothetical protein -
  VF946_RS09980 - 1971588..1972907 (+) 1320 WP_024405912.1 FtsK/SpoIIIE domain-containing protein -
  VF946_RS09985 - 1972997..1973311 (+) 315 WP_024405911.1 hypothetical protein -
  VF946_RS09990 - 1973352..1973741 (+) 390 WP_013851447.1 hypothetical protein -
  VF946_RS09995 - 1973904..1974698 (+) 795 WP_024395353.1 Rep protein -
  VF946_RS10000 - 1974705..1974974 (+) 270 WP_024405909.1 helix-turn-helix domain-containing protein -
  VF946_RS10005 xerC 1975017..1976237 (+) 1221 WP_024395351.1 tyrosine recombinase XerC -
  VF946_RS10010 - 1976668..1979694 (-) 3027 WP_074393251.1 DEAD/DEAH box helicase -
  VF946_RS10015 - 1979831..1981264 (-) 1434 WP_024405926.1 ATP-binding protein -
  VF946_RS10020 - 1981284..1984292 (-) 3009 WP_024405925.1 type I restriction endonuclease subunit R -
  VF946_RS10025 - 1984322..1984822 (-) 501 WP_024405924.1 TIR domain-containing protein -
  VF946_RS10030 - 1984822..1985649 (-) 828 WP_074389687.1 macro domain-containing protein -
  VF946_RS10035 - 1985706..1986866 (-) 1161 WP_024405922.1 restriction endonuclease subunit S -
  VF946_RS10040 xerA 1986880..1987866 (-) 987 WP_074412164.1 site-specific tyrosine recombinase/integron integrase -
  VF946_RS10045 - 1987921..1989033 (-) 1113 WP_074400570.1 restriction endonuclease subunit S -
  VF946_RS10050 - 1989023..1990528 (-) 1506 WP_024405918.1 type I restriction-modification system subunit M -
  VF946_RS10055 - 1990847..1991203 (-) 357 WP_024405917.1 hypothetical protein -
  VF946_RS10060 - 1991200..1991556 (-) 357 WP_074389691.1 plasmid mobilization protein -
  VF946_RS10065 - 1991549..1991839 (-) 291 WP_000158582.1 DUF5962 family protein -
  VF946_RS10070 - 1991850..1992704 (-) 855 WP_024405915.1 phage replisome organizer N-terminal domain-containing protein -
  VF946_RS10075 - 1992716..1993000 (-) 285 WP_001287945.1 hypothetical protein -
  VF946_RS10080 - 1993153..1993671 (+) 519 WP_003046517.1 helix-turn-helix domain-containing protein -
  VF946_RS10085 - 1993726..1994880 (+) 1155 WP_074389692.1 site-specific integrase -
  VF946_RS10090 cadX 1995417..1995755 (-) 339 WP_024414212.1 Cd(II)/Zn(II)-sensing metalloregulatory transcriptional regulator CadX -
  VF946_RS10095 - 1995767..1996381 (-) 615 WP_237374686.1 CadD family cadmium resistance transporter -
  VF946_RS10100 - 1996423..1996671 (-) 249 WP_237374688.1 CpXC domain-containing protein -
  VF946_RS10105 ant(9) 1997227..1998015 (-) 789 WP_170238912.1 aminoglycoside nucleotidyltransferase ANT(9) -
  VF946_RS10110 - 1998147..1998674 (-) 528 WP_002294507.1 phosphoribosyltransferase family protein -
  VF946_RS10115 - 1998718..1999164 (-) 447 Protein_1959 aminoglycoside 6-adenylyltransferase -
  VF946_RS11710 - 1999213..1999293 (-) 81 Protein_1960 AAA family ATPase -
  VF946_RS10120 - 1999508..2000968 (-) 1461 WP_002584327.1 Lsa family ABC-F type ribosomal protection protein -
  VF946_RS10125 - 2001715..2002011 (-) 297 WP_002594808.1 DUF3847 domain-containing protein -
  VF946_RS10130 - 2002010..2002180 (-) 171 Protein_1963 zinc ribbon domain-containing protein -

Sequence

Protein


Download         Length: 240 a.a.        Molecular weight: 28000.54 Da        Isoelectric Point: 4.0497

>NTDB_id=919776 VF946_RS09880 WP_012775334.1 1952044..1952766(-) (mecA) [Streptococcus suis strain HB18]
MKVKQISDSTLKITIKLDDLEERGMELSDFLIPQEKTEEFFYTVLDELDLPMTFRESGMLSFRVTPKPDRVDIFVTKSDL
DQNLNFDEFTDLSELGDVASMTPDEFFKSLEQTVREKSAPDATAVRHLEEVEQEEEADEEEQERYIYYILEFPTIEDLFT
FVGTVDYPVEESELYKMDGHYYLTVLINVENRSKQYPGYILSRMLEFTNDTKLTRPALQEHGTLMLPLAAIEELRKVPTV

Nucleotide


Download         Length: 723 bp        

>NTDB_id=919776 VF946_RS09880 WP_012775334.1 1952044..1952766(-) (mecA) [Streptococcus suis strain HB18]
ATGAAAGTAAAGCAAATTAGTGATTCAACCTTGAAAATCACTATAAAATTAGATGATTTGGAAGAGAGAGGAATGGAACT
TTCGGACTTTCTCATTCCGCAAGAAAAGACAGAGGAGTTCTTTTACACTGTTTTGGATGAATTGGATTTACCAATGACTT
TCCGAGAAAGCGGTATGCTGAGTTTTCGTGTGACTCCGAAGCCAGATCGGGTGGACATCTTTGTTACCAAATCTGATTTG
GATCAGAACTTGAATTTTGATGAATTTACAGATTTGTCGGAACTTGGTGATGTCGCAAGTATGACTCCAGATGAGTTTTT
CAAGAGTTTGGAGCAAACCGTTCGTGAGAAAAGTGCACCGGATGCAACAGCTGTTCGTCATTTGGAAGAGGTAGAGCAAG
AGGAAGAAGCAGATGAAGAGGAGCAGGAGCGCTATATTTACTATATTTTGGAATTTCCAACGATAGAGGATCTGTTTACT
TTTGTTGGTACGGTTGATTATCCAGTAGAAGAATCGGAATTATATAAAATGGATGGTCACTACTACTTGACAGTTCTTAT
CAATGTAGAAAATCGTTCCAAGCAGTATCCAGGCTACATTCTCTCAAGAATGTTGGAATTTACCAATGATACTAAGTTGA
CCAGACCTGCTTTACAAGAACACGGAACTTTGATGCTTCCGCTTGCGGCAATTGAGGAGCTTAGGAAGGTTCCGACAGTA
TGA

Domains

Predicted by InterproScan.

Negative regulator of genetic competence (MecA) (MecA)

(1-234)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  mecA Streptococcus pneumoniae Rx1

52.049

100

0.529
  mecA Streptococcus pneumoniae D39

52.049

100

0.529
  mecA Streptococcus pneumoniae R6

52.049

100

0.529
  mecA Streptococcus pneumoniae TIGR4

52.049

100

0.529
  mecA Streptococcus mutans UA159

50.41

100

0.513
  mecA Streptococcus thermophilus LMD-9

47.5

100

0.475
  mecA Streptococcus thermophilus LMG 18311

47.083

100

0.471