Detailed information NTG0919520

Bioinformatically predicted

Overview

• Name: comA
• Type: Regulator
• Locus tag: VA644_RS07760
• Genome accession: NZ_CP141796
• Coordinates: 1527103..1529262 (-)
• Length: 719 a.a.
• NCBI ID: WP_049159819.1
• Uniprot ID: I0IVV3
• Organism: Lactobacillus gasseri strain SYP-B4209
• Function: processing and transport of ComC (predicted from homology) Competence regulation

Genomic Context

Location: 1522103..1534262

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
VA644_RS07725 (VA644_07725)	-	1523308..1523622 (-)	315	WP_049159841.1	bacteriocin immunity protein	-
VA644_RS07730 (VA644_07730)	-	1523806..1524036 (-)	231	WP_003649208.1	hypothetical protein	-
VA644_RS07735 (VA644_07735)	-	1524050..1524247 (-)	198	WP_003649209.1	hypothetical protein	-
VA644_RS07740 (VA644_07740)	-	1524403..1524687 (-)	285	WP_195212017.1	bacteriocin immunity protein	-
VA644_RS07745 (VA644_07745)	-	1525763..1525960 (-)	198	WP_003649213.1	Blp family class II bacteriocin	-
VA644_RS07750 (VA644_07750)	-	1525970..1526197 (-)	228	WP_049159833.1	Blp family class II bacteriocin	-
VA644_RS07755 (VA644_07755)	-	1526499..1527092 (-)	594	WP_049159826.1	HlyD family efflux transporter periplasmic adaptor subunit	-
VA644_RS07760 (VA644_07760)	comA	1527103..1529262 (-)	2160	WP_049159819.1	peptide cleavage/export ABC transporter	Regulator
VA644_RS07765 (VA644_07765)	-	1529275..1530072 (-)	798	WP_324712099.1	LytTR family DNA-binding domain-containing protein	-
VA644_RS07770 (VA644_07770)	-	1530069..1531388 (-)	1320	WP_229036501.1	GHKL domain-containing protein	-
VA644_RS07775 (VA644_07775)	-	1531379..1531531 (-)	153	WP_003649220.1	hypothetical protein	-
VA644_RS07780 (VA644_07780)	-	1531674..1533041 (-)	1368	WP_048684932.1	MFS transporter	-
VA644_RS07785 (VA644_07785)	udk	1533203..1533838 (+)	636	WP_003649222.1	uridine kinase	-

Sequence

Protein

• Length: 719 a.a.
• Molecular weight: 81055.34 Da
• Isoelectric Point: 7.7712

>NTDB_id=919520 VA644_RS07760 WP_049159819.1 1527103..1529262(-) (comA) [Lactobacillus gasseri strain SYP-B4209]
MLFKYKSVYVPQVDEMDCGVACLAMILKQYHSRVSLAHLRHEARTNLEGTTALGLVKTAQKFNFKTEAVKADMSLFDENS
IQYPFIAHVLKQGELLHYYVVLKNAKNYLVIADPDPSVGVVKMPKDKFAQEWTGVALFMVPNEDFEPIKEKKNNLWSLFP
YMFKQKRLMINIILAALLMTIISICSSYFVQGIIDTYIPDGTYQTLSILAVGLLIAYVFNSIFSYGQNFLLNILGQRLSI
DLNLRYIRHIFELPMEFFVTRRTGEITSRFSDASRIIDALASTVISLFLDLSIVIVMGLVLAAQNMTLFGITLLALPIYA
VVILGFTKKFEKLNNEQMESNAVLSSSVIEDIQGIETIKALNSENTRYRRIDSQFVDYLKKSFKYSKTESLQTALKTFIQ
LSLNVIVLWVGAKIVMQGQLSIGQLMTFNALLAYFIDPLQSIINLQPRLQSASVAQNRLNEVYQVKSEFNQKATIEDRKL
LEGNIEYKNVDYSYGYGTDVLKDINLKISQGEKLTIVGMSGSGKSTMVKLLVDFFSPSKGQVTLNGHATSEIDKHTLRSY
VNYVPQTPYIFSGTVKENLLLGCRPDITEEDVIKACQIAEIDQEIANLPLQFETKLDENAKILSGGQKQRLTIARALLSP
AKVFIFDEVTSGLDTITEKKVVDNLMKLKDKTIIFIAHRLAIAERADKVVVIDHGQIVEEGSHSELMSKHGFYYDLVKG

Nucleotide

• Length: 2160 bp

>NTDB_id=919520 VA644_RS07760 WP_049159819.1 1527103..1529262(-) (comA) [Lactobacillus gasseri strain SYP-B4209]
ATGTTATTCAAATATAAATCCGTATACGTGCCACAAGTGGATGAGATGGATTGCGGCGTTGCTTGTCTAGCAATGATCTT
AAAGCAATATCATTCTCGCGTATCTTTAGCACATTTACGTCATGAAGCTCGTACTAATCTTGAAGGCACAACTGCTTTAG
GACTAGTGAAGACAGCACAAAAATTTAATTTCAAAACAGAAGCCGTAAAAGCAGATATGTCTTTATTTGATGAGAATAGT
ATTCAATATCCTTTTATTGCCCACGTCCTAAAACAAGGAGAACTACTTCATTATTACGTAGTTCTTAAAAATGCTAAGAA
TTATTTAGTAATTGCAGATCCTGATCCATCAGTTGGTGTAGTAAAGATGCCAAAAGACAAATTTGCTCAAGAATGGACTG
GTGTTGCACTCTTTATGGTTCCTAACGAAGACTTTGAACCAATCAAAGAAAAGAAGAATAATTTATGGTCTCTCTTTCCA
TATATGTTTAAACAAAAGCGGCTGATGATTAACATCATTTTAGCCGCTTTATTAATGACCATAATTAGTATCTGTAGTTC
ATATTTTGTTCAAGGAATAATTGATACTTACATTCCAGATGGAACCTATCAGACTCTTTCGATCTTAGCTGTTGGACTAT
TAATTGCTTATGTCTTTAATTCAATTTTTTCTTATGGACAGAATTTTTTATTAAATATTTTAGGTCAAAGATTAAGTATT
GATCTAAATCTGCGATACATCAGGCATATTTTTGAATTACCAATGGAATTCTTTGTAACAAGAAGAACGGGTGAAATTAC
TTCGCGTTTTTCTGATGCAAGTAGAATTATTGACGCTTTGGCAAGTACAGTTATTTCGCTCTTCTTAGACCTCTCAATTG
TGATTGTGATGGGATTAGTCTTAGCAGCACAAAATATGACATTATTTGGGATTACACTGTTAGCTTTGCCTATTTATGCA
GTTGTAATTCTAGGTTTTACTAAAAAGTTTGAAAAACTAAATAACGAACAAATGGAAAGTAATGCTGTTTTGAGTTCTTC
AGTTATTGAAGATATTCAAGGAATTGAAACTATTAAAGCTTTAAATAGTGAGAATACAAGATATAGAAGAATCGATAGTC
AGTTTGTAGATTACTTAAAGAAGTCATTTAAATATAGTAAGACTGAGAGTTTACAGACAGCACTCAAGACATTTATTCAA
TTATCTCTTAATGTAATTGTTCTTTGGGTTGGTGCAAAGATTGTAATGCAAGGACAATTGAGCATTGGTCAGTTAATGAC
GTTCAATGCATTGCTGGCATATTTCATTGATCCCTTGCAAAGTATTATTAATTTACAACCGCGACTTCAATCAGCTAGTG
TTGCTCAAAATCGATTAAATGAGGTCTATCAAGTAAAAAGTGAATTCAATCAGAAGGCTACTATTGAAGATCGTAAGCTC
CTAGAAGGAAATATTGAATATAAGAATGTGGATTATAGCTATGGTTATGGCACAGATGTCTTAAAAGATATTAATCTCAA
AATTAGCCAGGGCGAAAAATTAACGATTGTTGGAATGAGTGGTTCTGGAAAATCTACGATGGTTAAGTTGTTAGTAGATT
TCTTTTCGCCAAGTAAAGGTCAGGTTACATTAAATGGACATGCAACAAGTGAGATTGATAAGCATACGTTGCGGTCATAT
GTAAATTATGTACCTCAAACTCCATATATCTTTTCTGGAACAGTTAAAGAGAATTTGTTGTTAGGTTGTAGGCCAGATAT
CACTGAAGAAGATGTAATAAAGGCTTGTCAAATTGCTGAGATTGACCAAGAAATAGCTAATCTACCTTTGCAATTTGAAA
CAAAATTAGATGAAAATGCCAAAATTTTATCTGGTGGACAAAAACAAAGGTTAACTATTGCCCGGGCATTACTATCTCCT
GCAAAGGTATTTATTTTTGATGAAGTAACAAGTGGCTTAGATACAATTACTGAGAAGAAAGTGGTTGATAATTTGATGAA
GCTAAAGGATAAGACAATTATCTTTATTGCGCATCGACTAGCAATTGCAGAACGGGCAGACAAGGTAGTTGTAATTGATC
ATGGTCAAATAGTTGAAGAAGGCAGCCACAGCGAATTGATGAGTAAGCATGGTTTTTACTATGACTTAGTGAAGGGATAG

Domains

Predicted by InterproScan.

• ABC transporter transmembrane region (ABC_membrane) (169-439)

• Peptidase C39 family (Peptidase_C39) (7-143)

• ABC transporter (ABC_tran) (501-651)

3D structure

• AlphaFold DB: I0IVV3

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comA	Streptococcus mitis NCTC 12261	57.865	99.026	0.573
comA	Streptococcus mitis SK321	57.584	99.026	0.57
comA	Streptococcus pneumoniae Rx1	57.444	99.026	0.569
comA	Streptococcus pneumoniae D39	57.444	99.026	0.569
comA	Streptococcus pneumoniae R6	57.444	99.026	0.569
comA	Streptococcus pneumoniae TIGR4	57.303	99.026	0.567
comA	Streptococcus gordonii str. Challis substr. CH1	55.337	99.026	0.548
comA/nlmT	Streptococcus mutans UA159	53.607	98.331	0.527