Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   VNN46_RS04305 Genome accession   NZ_CP141719
Coordinates   870810..872027 (-) Length   405 a.a.
NCBI ID   WP_003133516.1    Uniprot ID   A0A3D4RHV6
Organism   Lactococcus garvieae strain CAHFS22LA20.5H7     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 865810..877027
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  VNN46_RS04280 (VNN46_04280) - 866108..866857 (+) 750 WP_019298937.1 tRNA1(Val) (adenine(37)-N6)-methyltransferase -
  VNN46_RS04285 (VNN46_04285) - 867016..868065 (+) 1050 WP_003133520.1 BMP family protein -
  VNN46_RS04290 (VNN46_04290) - 868092..868316 (-) 225 WP_003133519.1 DUF1797 family protein -
  VNN46_RS04295 (VNN46_04295) - 868367..869701 (-) 1335 WP_003133518.1 glycosyltransferase family 4 protein -
  VNN46_RS04300 (VNN46_04300) - 869714..870712 (-) 999 WP_264308069.1 glycosyltransferase family 4 protein -
  VNN46_RS04305 (VNN46_04305) htrA 870810..872027 (-) 1218 WP_003133516.1 S1C family serine protease Regulator
  VNN46_RS04310 (VNN46_04310) rlmH 872331..872810 (+) 480 WP_338962859.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  VNN46_RS04315 (VNN46_04315) - 872807..873454 (+) 648 WP_338962862.1 DNA alkylation repair protein -
  VNN46_RS04320 (VNN46_04320) yajC 873529..873864 (+) 336 WP_338962865.1 preprotein translocase subunit YajC -
  VNN46_RS04325 (VNN46_04325) - 874064..874801 (+) 738 WP_003133511.1 isoprenyl transferase -
  VNN46_RS04330 (VNN46_04330) - 874798..875592 (+) 795 WP_003133509.1 phosphatidate cytidylyltransferase -
  VNN46_RS04335 (VNN46_04335) eeP 875768..877015 (+) 1248 WP_014025467.1 RIP metalloprotease RseP Regulator

Sequence

Protein


Download         Length: 405 a.a.        Molecular weight: 41787.63 Da        Isoelectric Point: 4.8808

>NTDB_id=918813 VNN46_RS04305 WP_003133516.1 870810..872027(-) (htrA) [Lactococcus garvieae strain CAHFS22LA20.5H7]
MAKKNIASLLITGVAGGAIALGGSAIYQNMTNTPSSNNTSDNSVSTVNVQVNTDTTKAIKKISNTVVSVLNYQKSSSSND
FEKIFGGGDTSSNDSNTPQLAGEGSGVIYKKDGNTAYIVTNYHVIEGASSLEVLMAGGQKVTAEVVGSDAYSDLAVLKID
AKYVKETATFGNSDKLTVGEPAIAVGSPLGSEYANSATEGIVSSLNRNVTLQNSQGQTINVNAIQTDAAINPGNSGGALI
NIQGQVIGITSSKITSTPSGTSGSGVSVEGMGFAIPANDVVNIINKLEKDGKVIRPALGVQMVNLSSLSQNMLASLNLPE
NVTNGVAIAEVQSGMPAAKAGLKQGDVIVKINDDEITSSVNLQSTLYKSSIGDTIKVTYYRDGKQATANIKLDKTSSDIN
FDKQN

Nucleotide


Download         Length: 1218 bp        

>NTDB_id=918813 VNN46_RS04305 WP_003133516.1 870810..872027(-) (htrA) [Lactococcus garvieae strain CAHFS22LA20.5H7]
ATGGCAAAGAAAAATATCGCCTCATTACTTATTACGGGCGTAGCCGGAGGTGCTATCGCTCTTGGAGGTAGTGCTATCTA
CCAAAACATGACCAACACACCATCATCTAATAACACTTCGGACAATTCTGTAAGTACGGTTAACGTCCAAGTCAATACAG
ATACCACCAAAGCAATCAAGAAAATTTCGAACACTGTTGTTTCCGTTCTTAATTACCAAAAATCATCCTCAAGCAACGAT
TTTGAGAAGATTTTCGGTGGAGGCGATACAAGCAGCAATGACAGTAACACGCCACAGTTGGCTGGTGAAGGTTCTGGTGT
TATTTATAAAAAAGATGGCAATACAGCATACATCGTCACCAACTATCACGTGATTGAAGGTGCTTCTTCCTTAGAAGTTC
TCATGGCTGGCGGCCAAAAAGTTACTGCTGAAGTTGTTGGTTCTGATGCTTATTCTGATTTAGCTGTCCTCAAAATTGAT
GCTAAGTATGTCAAAGAAACAGCAACATTCGGTAACTCTGACAAACTTACTGTTGGTGAGCCCGCTATCGCGGTTGGTTC
TCCTCTTGGAAGTGAGTATGCTAACTCAGCAACGGAAGGGATTGTTTCAAGTCTTAATCGTAATGTTACGCTGCAAAACA
GCCAAGGCCAAACAATTAATGTGAACGCAATTCAAACCGATGCAGCAATTAACCCAGGTAACTCTGGTGGTGCACTCATA
AATATTCAGGGACAAGTCATCGGGATTACTTCAAGTAAAATTACCTCAACACCAAGCGGAACAAGCGGCAGTGGTGTCTC
TGTAGAAGGAATGGGTTTTGCGATTCCAGCCAATGATGTGGTCAATATTATCAATAAGTTGGAAAAAGATGGCAAAGTTA
TTCGACCTGCTCTCGGTGTACAAATGGTCAACTTGTCAAGTCTTTCACAAAATATGTTGGCTTCACTTAATCTTCCTGAA
AATGTGACAAATGGTGTTGCTATCGCTGAAGTTCAATCAGGAATGCCTGCTGCCAAAGCTGGACTCAAGCAAGGTGACGT
TATTGTCAAAATCAATGATGACGAAATCACTTCAAGTGTGAACCTTCAAAGTACACTTTATAAGTCATCGATTGGTGATA
CGATTAAGGTAACTTATTATCGTGACGGAAAACAAGCTACTGCGAATATCAAGTTAGATAAGACAAGTAGTGACATCAAC
TTTGACAAACAAAATTAA

Domains

Predicted by InterproScan.

Trypsin-like peptidase domain (Trypsin_2)

(104-249)

PDZ domain (PDZ_2)

(296-392)

Peptidase family M50 (Peptidase_M50)

(294-396)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A3D4RHV6

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus mitis NCTC 12261

53.634

98.519

0.528
  htrA Streptococcus pneumoniae Rx1

53.383

98.519

0.526
  htrA Streptococcus pneumoniae D39

53.383

98.519

0.526
  htrA Streptococcus pneumoniae R6

53.383

98.519

0.526
  htrA Streptococcus pneumoniae TIGR4

53.383

98.519

0.526
  htrA Streptococcus mutans UA159

56.085

93.333

0.523
  htrA Streptococcus gordonii str. Challis substr. CH1

54.22

96.543

0.523