NTDB

Overview

Name	htrA	Type	Regulator
Locus tag	U8771_RS04575	Genome accession	NZ_CP141640
Coordinates	962657..963961 (-)	Length	434 a.a.
NCBI ID	WP_015509239.1	Uniprot ID	A0A200IEL7
Organism	Enterococcus casseliflavus strain Dec0527
Function	require for competence development (predicted from homology) Competence regulation

Genomic Context

Location: 957657..968961

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
U8771_RS04545 (U8771_04545)	-	957659..958693 (+)	1035	WP_262119073.1	hypothetical protein	-
U8771_RS04550 (U8771_04550)	-	958754..959098 (-)	345	WP_005234590.1	peptidase	-
U8771_RS04555 (U8771_04555)	pepA	959391..960467 (+)	1077	WP_324641588.1	glutamyl aminopeptidase	-
U8771_RS04560 (U8771_04560)	-	960601..960921 (+)	321	WP_324640926.1	thioredoxin family protein	-
U8771_RS04565 (U8771_04565)	-	960934..961395 (+)	462	WP_005225429.1	universal stress protein	-
U8771_RS04570 (U8771_04570)	ytpR	961974..962588 (+)	615	WP_142964304.1	YtpR family tRNA-binding protein	-
U8771_RS04575 (U8771_04575)	htrA	962657..963961 (-)	1305	WP_015509239.1	S1C family serine protease	Regulator
U8771_RS04580 (U8771_04580)	rlmH	964335..964814 (+)	480	WP_142972842.1	23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH	-
U8771_RS04585 (U8771_04585)	truA	964881..965618 (+)	738	WP_005225435.1	tRNA pseudouridine(38-40) synthase TruA	-
U8771_RS04590 (U8771_04590)	map	965661..966446 (+)	786	WP_142962483.1	type I methionyl aminopeptidase	-
U8771_RS04595 (U8771_04595)	-	966507..966605 (+)	99	WP_123906405.1	type I toxin-antitoxin system Fst family toxin	-
U8771_RS04600 (U8771_04600)	-	966952..967119 (+)	168	WP_123906404.1	hypothetical protein	-
U8771_RS04605 (U8771_04605)	-	967406..967669 (+)	264	WP_074932272.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	-
U8771_RS04610 (U8771_04610)	-	967663..968013 (+)	351	WP_096741485.1	type II toxin-antitoxin system PemK/MazF family toxin	-
U8771_RS04615 (U8771_04615)	-	968329..968736 (-)	408	WP_317720856.1	AsnC family transcriptional regulator	-

Sequence

Protein

Download Length: 434 a.a. Molecular weight: 44863.37 Da Isoelectric Point: 4.0412

                                >NTDB_id=917794 U8771_RS04575 WP_015509239.1 962657..963961(-) (htrA) [Enterococcus casseliflavus strain Dec0527]

MARKYVTPGKKTSPGLLKRLGIGILGGMVGGLLTFGGLYLAMGSSLTSTPETTTNSGVQDSNGQTQVSNVKLDVTSDVTE

AVEKVQDSVVSIINLQQSQSNDWNSLFGQQGGQSEGDSQSDDDSALEASSEGSGVIYKIDGDDAYVVTNNHVVEGQDGLE

VVLADGTKVKAELVGTDAYTDLAVLKISSEHVKTAATFGDSSALKVGEPAIAIGSPLGSDYANSVTQGIVSSLNRQVTSQ

NESGGTISINAIQTDAAINPGNSGGPLINVDGQVIGINSSKIASTSGSASGVSVEGMGFAIPSNDVVEIINQLEADGKVV

RPALGIQTIDLGSITSQQQEQILKVPSSVTSGVVIYSVNNATPAEQAGLQQYDVITKIDDTEVSTTTDLQSALYKHKVGD

TITVTFYRGDEEKTAEVKLSVDTSINEQSTDSSN

Nucleotide

Download Length: 1305 bp

                                >NTDB_id=917794 U8771_RS04575 WP_015509239.1 962657..963961(-) (htrA) [Enterococcus casseliflavus strain Dec0527]

ATGGCAAGAAAATATGTCACACCAGGCAAGAAAACTTCTCCTGGTTTATTAAAACGATTAGGTATTGGGATTTTAGGCGG

TATGGTCGGCGGTTTATTGACCTTCGGCGGTCTGTATCTGGCAATGGGTTCCTCTTTGACTTCAACACCAGAAACCACGA

CCAACAGCGGGGTCCAAGATTCTAACGGACAAACCCAAGTATCCAATGTAAAACTTGATGTGACTAGCGATGTCACTGAG

GCAGTTGAAAAAGTACAAGATTCTGTCGTTTCCATCATTAATCTACAACAAAGTCAAAGCAACGATTGGAACAGCCTCTT

TGGTCAGCAAGGCGGACAAAGTGAAGGCGATAGCCAAAGCGATGACGACAGTGCTTTAGAAGCTTCTTCTGAAGGGAGTG

GGGTCATCTACAAAATCGATGGCGACGATGCCTATGTTGTAACCAACAACCACGTCGTAGAAGGTCAAGACGGTTTAGAA

GTTGTTTTAGCAGACGGTACGAAAGTCAAAGCTGAATTGGTCGGTACTGACGCTTACACAGACTTAGCTGTATTGAAAAT

CTCTTCAGAGCATGTGAAGACTGCCGCAACATTTGGTGATTCAAGTGCCTTGAAAGTCGGCGAACCAGCCATCGCGATCG

GTTCTCCTCTAGGCTCTGACTACGCAAACTCTGTGACACAAGGGATCGTTTCTTCCTTGAATCGTCAAGTAACAAGCCAA

AACGAATCTGGTGGTACGATCAGCATCAATGCGATCCAAACGGATGCTGCGATTAACCCAGGGAACTCTGGTGGTCCACT

GATCAACGTTGATGGCCAAGTGATTGGGATCAACTCAAGTAAAATCGCCAGCACCTCGGGCTCTGCTTCAGGTGTTAGTG

TCGAAGGGATGGGCTTTGCGATCCCAAGTAACGATGTCGTTGAAATCATCAATCAACTAGAAGCAGACGGCAAAGTGGTT

CGCCCTGCACTAGGGATCCAAACGATCGATTTAGGTTCCATCACATCACAACAACAAGAACAAATCTTGAAAGTTCCTTC

ATCCGTAACTTCTGGCGTTGTGATTTACTCAGTCAACAATGCAACACCAGCAGAACAAGCAGGATTGCAACAATATGACG

TTATCACGAAGATCGATGATACAGAAGTCAGCACAACAACGGATCTGCAATCTGCGTTGTACAAACACAAAGTCGGTGAC

ACGATCACTGTAACCTTCTATCGTGGCGATGAAGAAAAAACGGCAGAAGTAAAACTTTCCGTTGATACGTCGATCAACGA

ACAATCAACAGACAGCAGCAACTAA

Domains

Predicted by InterproScan.

Trypsin-like peptidase domain (Trypsin_2)

(132-277)

Peptidase family M50 (Peptidase_M50)

(18-420)

PDZ domain (PDZ_2)

(322-419)

Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.

3D structure

Source	ID	Structure
AlphaFold DB	A0A200IEL7

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.

Visualization of predicted probability:

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	H_a-value
htrA	Streptococcus mutans UA159	56.171	91.475	0.514
htrA	Streptococcus gordonii str. Challis substr. CH1	51.074	96.544	0.493
htrA	Streptococcus mitis NCTC 12261	55.432	82.719	0.459
htrA	Streptococcus pneumoniae TIGR4	57.018	78.802	0.449
htrA	Streptococcus pneumoniae Rx1	57.018	78.802	0.449
htrA	Streptococcus pneumoniae D39	57.018	78.802	0.449
htrA	Streptococcus pneumoniae R6	57.018	78.802	0.449

Detailed information NTG0917794