Detailed information NTG0917518

Bioinformatically predicted

Overview

• Name: comA
• Type: Regulator
• Locus tag: U8C12_RS12325
• Genome accession: NZ_CP141586
• Coordinates: 2546276..2548468 (-)
• Length: 730 a.a.
• NCBI ID: WP_003607148.1
• Uniprot ID: -
• Organism: Lacticaseibacillus paracasei strain HP-B1337
• Function: processing and transport of ComC (predicted from homology) Competence regulation

Genomic Context

Location: 2541276..2553468

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
U8C12_RS12295 (U8C12_12295)	-	2541441..2541725 (-)	285	WP_003580845.1	bacteriocin immunity protein	-
U8C12_RS12300 (U8C12_12300)	-	2541919..2542215 (-)	297	WP_003588783.1	bacteriocin immunity protein	-
U8C12_RS12305 (U8C12_12305)	-	2542317..2543672 (-)	1356	WP_003567335.1	threonine/serine exporter ThrE family protein	-
U8C12_RS12310 (U8C12_12310)	-	2543978..2544289 (-)	312	WP_003580849.1	hypothetical protein	-
U8C12_RS12315 (U8C12_12315)	-	2544362..2544712 (-)	351	WP_003567340.1	hypothetical protein	-
U8C12_RS12320 (U8C12_12320)	-	2544886..2546265 (-)	1380	WP_003588791.1	bacteriocin secretion accessory protein	-
U8C12_RS12325 (U8C12_12325)	comA	2546276..2548468 (-)	2193	WP_003607148.1	peptide cleavage/export ABC transporter	Regulator
U8C12_RS12330 (U8C12_12330)	-	2548933..2549070 (-)	138	WP_003576291.1	bacteriocin-like peptide, LSEI_2386 family	-
U8C12_RS12335 (U8C12_12335)	-	2549439..2550557 (+)	1119	WP_016365086.1	GHKL domain-containing protein	-
U8C12_RS12340 (U8C12_12340)	-	2550562..2551056 (+)	495	Protein_2409	response regulator	-
U8C12_RS12345 (U8C12_12345)	-	2551078..2551998 (-)	921	WP_003574021.1	IS30 family transposase	-
U8C12_RS12350 (U8C12_12350)	-	2552109..2552423 (+)	315	Protein_2411	LytTR family DNA-binding domain-containing protein	-
U8C12_RS12355 (U8C12_12355)	-	2552885..2553136 (+)	252	WP_003586983.1	IS3 family transposase	-

Sequence

Protein

• Length: 730 a.a.
• Molecular weight: 81338.54 Da
• Isoelectric Point: 7.0227

>NTDB_id=917518 U8C12_RS12325 WP_003607148.1 2546276..2548468(-) (comA) [Lacticaseibacillus paracasei strain HP-B1337]
MIKYNLKLGQAQYYKRYYTPQVDERDCGVAALNMLLQFNGSDYSLAHLRQLAKTDQEGTTALGIVRAAQALHFETKAVKA
DMTLFDLDDVPYPFLVHVLKRGELLHYYVVFKATKDHILIGDPDSSVAMTWLPKERFAKEWSGVAIFIAPEPQYQPRKED
KGSLFAFVPMLARQKGIIANIIVAAVLITLISIVGSYFLQSIIDTYIPNGMRTTLGMIASGLILAYVLQSVLTYGQNFLM
AVLGQRLSIDVILGYVRHLYELPMSFFSTRRTGEIVSRFSDANKIIDALANTIMTLFLDIWIVLILGIVLGIQNTTLFLV
SLIAVPCYLVIVFAFQRTFNRLNQETMESNAILSSSIIEDLNGIETIKSLTGEKVSYERVDREFVTYLKKSFNYTKADQL
QQAIKGLLKLVLNVVVLWIGASLVMANKMSLGQMLTFNALLAYFTNPLESIINLQPKLQMAKVANNRLNEVYLVESEFKE
QRSLNDRHLIDGAINVTDVSFKYGFGQDVLKQINLEIPENAKYTIVGMSGSGKSTLAKLLVGFYPVDTGKGKITFNGVPI
TDVDLTTLRQYIEYVPQDPFIFSGSVIENLTLGSRSNITEADIEAACSVAEIAGDISNLPQIWQTKLSESGSILSGGQKQ
RLAIARALLSPAKVLIFDESTSSLDTITERKIVDRLLAMTDRTIIFVAHRLTIAAKTEQIVVMDHGAIVEQGNHTELLAK
QGYYARLVSE

Nucleotide

• Length: 2193 bp

>NTDB_id=917518 U8C12_RS12325 WP_003607148.1 2546276..2548468(-) (comA) [Lacticaseibacillus paracasei strain HP-B1337]
ATGATCAAATACAACCTAAAGCTCGGCCAAGCACAGTATTACAAGCGTTACTACACGCCTCAGGTGGATGAGCGCGATTG
CGGGGTTGCGGCGCTTAATATGCTGCTGCAATTTAATGGCTCGGATTATTCGCTAGCGCATCTGCGACAGTTGGCGAAGA
CGGATCAGGAAGGAACAACAGCGTTAGGGATTGTCCGAGCTGCTCAGGCGCTTCATTTTGAAACCAAGGCTGTCAAGGCG
GATATGACGCTGTTTGATCTTGATGATGTTCCTTATCCGTTTCTTGTCCATGTTTTGAAGCGTGGCGAGTTGCTTCATTA
TTATGTGGTGTTTAAGGCGACAAAGGATCATATCTTGATTGGCGATCCTGATTCATCAGTAGCGATGACCTGGCTTCCCA
AAGAGCGCTTTGCGAAGGAGTGGTCGGGGGTCGCTATTTTTATTGCGCCAGAACCGCAATATCAACCACGCAAAGAGGAC
AAAGGCAGTCTCTTTGCGTTTGTGCCGATGCTAGCGCGACAAAAAGGAATCATTGCCAATATTATTGTCGCCGCTGTGTT
GATCACGTTGATTAGTATTGTCGGGTCTTATTTTCTTCAGTCGATTATTGATACTTATATTCCAAACGGGATGCGCACAA
CTTTGGGAATGATTGCCAGTGGTCTCATCCTCGCTTATGTGCTGCAGTCGGTTTTAACCTATGGGCAAAATTTTTTGATG
GCTGTTTTAGGACAACGTTTGTCGATTGATGTCATTTTGGGTTACGTCAGACACCTTTATGAATTACCTATGTCCTTCTT
TTCCACGCGTCGGACTGGGGAAATTGTGTCGCGGTTTTCCGATGCTAATAAAATTATTGATGCGCTGGCGAACACGATTA
TGACCTTGTTTCTTGATATTTGGATTGTCTTAATTTTAGGGATCGTGTTAGGCATTCAAAACACCACCTTATTCTTGGTG
TCTTTAATTGCTGTGCCTTGTTATTTGGTGATTGTGTTCGCTTTTCAGCGGACATTTAATCGACTGAATCAAGAGACGAT
GGAAAGCAATGCCATTTTGAGTTCATCTATTATCGAGGATTTGAACGGGATTGAGACGATTAAATCACTGACCGGTGAGA
AAGTCAGTTATGAACGGGTTGACCGTGAATTCGTCACGTATTTGAAAAAGTCGTTCAATTATACAAAAGCTGATCAACTG
CAGCAGGCGATCAAGGGACTGCTGAAGTTGGTTTTGAATGTGGTCGTGCTGTGGATTGGTGCGAGTTTGGTGATGGCTAA
CAAGATGAGTCTAGGACAGATGCTGACGTTCAATGCGTTGTTGGCATATTTCACCAATCCGTTAGAAAGCATCATTAATT
TGCAACCAAAATTGCAAATGGCCAAAGTCGCGAATAACCGGCTGAATGAAGTGTATTTGGTTGAATCGGAGTTTAAAGAA
CAGCGAAGTTTGAATGATCGGCATTTAATTGATGGCGCCATCAATGTTACCGATGTGTCCTTTAAGTATGGTTTTGGGCA
AGATGTTTTGAAACAAATCAACCTTGAAATCCCGGAAAATGCCAAATACACCATTGTCGGCATGAGTGGATCAGGGAAAT
CGACCTTAGCCAAGTTGCTAGTAGGTTTCTATCCAGTGGACACTGGCAAAGGGAAAATCACATTTAATGGGGTTCCAATC
ACTGATGTTGATCTAACAACGTTACGACAATATATCGAGTATGTACCACAAGATCCGTTTATTTTTTCTGGCTCAGTCAT
TGAAAACTTAACGTTGGGTAGCCGTTCGAATATCACTGAAGCCGATATTGAAGCTGCCTGTTCAGTGGCGGAAATTGCCG
GAGATATTTCGAATTTGCCGCAGATATGGCAGACCAAACTTTCTGAAAGCGGCAGTATTTTATCGGGTGGACAAAAGCAG
CGCCTAGCCATTGCCCGCGCGTTATTATCACCGGCAAAAGTGTTGATTTTTGATGAATCGACCAGCAGTTTAGATACGAT
CACCGAGCGAAAAATTGTTGATCGGTTGTTAGCAATGACTGATCGAACCATTATTTTTGTGGCTCATCGGCTCACTATTG
CTGCTAAAACGGAACAGATTGTGGTCATGGACCATGGTGCGATTGTTGAACAAGGAAATCATACTGAGTTATTGGCCAAA
CAAGGCTATTATGCTCGGTTGGTAAGTGAGTGA

Domains

Predicted by InterproScan.

• ABC transporter (ABC_tran) (510-662)

• Peptidase C39 family (Peptidase_C39) (16-152)

• ABC transporter transmembrane region (ABC_membrane) (180-448)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comA	Streptococcus mitis NCTC 12261	58.496	98.356	0.575
comA	Streptococcus pneumoniae Rx1	57.939	98.356	0.57
comA	Streptococcus pneumoniae D39	57.939	98.356	0.57
comA	Streptococcus pneumoniae R6	57.939	98.356	0.57
comA	Streptococcus mitis SK321	57.799	98.356	0.568
comA	Streptococcus pneumoniae TIGR4	57.521	98.356	0.566
comA	Streptococcus gordonii str. Challis substr. CH1	56.825	98.356	0.559
comA/nlmT	Streptococcus mutans UA159	54.709	98.904	0.541