Detailed information NTG0917056

Bioinformatically predicted

Overview

• Name: comA
• Type: Regulator
• Locus tag: UHR80_RS07420
• Genome accession: NZ_CP141330
• Coordinates: 1615849..1618041 (-)
• Length: 730 a.a.
• NCBI ID: WP_014570077.1
• Uniprot ID: A0A809N5K4
• Organism: Lacticaseibacillus rhamnosus strain S262-4W
• Function: processing and transport of ComC (predicted from homology) Competence regulation

Genomic Context

Location: 1610849..1623041

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
UHR80_RS07400 (UHR80_07400)	-	1611069..1612151 (+)	1083	WP_048653151.1	aldo/keto reductase	-
UHR80_RS07405 (UHR80_07405)	-	1612454..1613809 (-)	1356	WP_005711099.1	threonine/serine exporter ThrE family protein	-
UHR80_RS07410 (UHR80_07410)	-	1613986..1614396 (-)	411	WP_005692253.1	hypothetical protein	-
UHR80_RS07415 (UHR80_07415)	-	1614457..1615836 (-)	1380	WP_014570076.1	bacteriocin secretion accessory protein	-
UHR80_RS07420 (UHR80_07420)	comA	1615849..1618041 (-)	2193	WP_014570077.1	peptide cleavage/export ABC transporter	Regulator
UHR80_RS07425 (UHR80_07425)	-	1618290..1618424 (-)	135	WP_005692249.1	bacteriocin-like peptide, LSEI_2386 family	-
UHR80_RS07430 (UHR80_07430)	-	1618600..1619913 (+)	1314	WP_014570078.1	GHKL domain-containing protein	-
UHR80_RS07435 (UHR80_07435)	-	1619906..1620694 (+)	789	WP_014570079.1	response regulator transcription factor	-
UHR80_RS07440 (UHR80_07440)	-	1621431..1621616 (+)	186	WP_076638842.1	bacteriocin	-
UHR80_RS07445 (UHR80_07445)	-	1622076..1622330 (-)	255	WP_162467050.1	hypothetical protein	-

Sequence

Protein

• Length: 730 a.a.
• Molecular weight: 81570.85 Da
• Isoelectric Point: 7.2813

>NTDB_id=917056 UHR80_RS07420 WP_014570077.1 1615849..1618041(-) (comA) [Lacticaseibacillus rhamnosus strain S262-4W]
MFKHTPKLGQITYYKRFYTAQVDERDCGVAALNMLLKYNGSDYSLAHLRELAKTNQDGTTALGIVRAAEALAFETKPVQA
NMQLFDLEDVPYPFIAHVLKRGELLHYYVVFKATRTSILIGDPDPSVRMTWLSREVFEKEWSGVAIFIAPAPQYQPRKED
KGSLFAFVPMLAKQKGIIANIILAAVLITVISIVGSYFLQSIIDTYIPNAMRTTMGMIASGLLVAYLLQAVLTYGQNFLM
AVLGQRLAIDVILGYVRHLYELPMSFFSTRRTGEIVSRFADANKIIDALANTIMTLFLDVWIVLILGIVLGIQNGTLFLV
SLIAVPCYLVIVFAFQRPFDRLNQETMESNAILSSSIIEDLNGIETIKSLTGERVSYERVDREFLTYLKRSFSYTKADQL
QQAIKGLLKLALNVVVLWIGASLVIANRMSLGQMLTFNALLSYFTNPLESIINLQPKLQMARVANNRLNEVYLVESEFKE
PRHLTERHLIEGPLRVRDVSFKYGFGQDVLKNINLEVPENAKYTIVGMSGSGKSTLAKLLVGFYPVDTDKGTITFNGIPV
KDINLTTLRQYIEYVPQDPFIFSGTVLENLTLGSRSDVSEQDLTQACLAAEIAADIANLPQQWQTKLSESGSILSGGQKQ
RLAIARALLSPAKVLIFDESTSSLDTITERKIVDRLLAMTDRTIIFVAHRLTIAAKTEQIVVMDHGKIVEQGDHATLLAQ
DGYYARLVHE

Nucleotide

• Length: 2193 bp

>NTDB_id=917056 UHR80_RS07420 WP_014570077.1 1615849..1618041(-) (comA) [Lacticaseibacillus rhamnosus strain S262-4W]
ATGTTTAAACACACCCCCAAACTAGGCCAGATCACCTACTACAAACGCTTCTACACCGCACAAGTTGACGAGCGTGACTG
TGGTGTGGCTGCGTTAAACATGCTGCTTAAATACAATGGGTCGGACTATTCGTTAGCCCACTTGCGCGAGTTAGCGAAGA
CAAATCAGGATGGCACGACGGCTTTGGGAATTGTTCGGGCCGCTGAAGCACTAGCGTTTGAGACGAAACCGGTGCAGGCG
AATATGCAGTTGTTTGATCTTGAGGATGTGCCTTATCCGTTTATTGCCCATGTGCTGAAGCGCGGTGAATTGCTTCATTA
CTATGTTGTTTTTAAAGCAACGCGCACGAGTATTCTGATTGGCGATCCTGACCCGTCAGTGCGCATGACCTGGCTTTCGC
GAGAGGTGTTTGAAAAAGAATGGTCGGGTGTGGCCATCTTTATTGCACCGGCGCCGCAGTATCAGCCGCGTAAGGAGGAC
AAAGGCAGTTTGTTTGCGTTTGTACCCATGCTGGCTAAGCAAAAAGGTATTATCGCGAACATTATTCTGGCCGCGGTATT
GATTACGGTCATTAGTATCGTTGGGTCGTATTTTTTGCAGTCTATTATTGATACGTATATACCGAATGCCATGCGGACGA
CGATGGGGATGATTGCTAGTGGCCTTTTGGTGGCTTACTTGCTGCAAGCTGTGTTGACTTATGGCCAGAATTTTTTGATG
GCGGTGTTGGGGCAGCGGCTTGCGATTGATGTCATTTTAGGGTATGTGCGCCATTTATATGAATTGCCGATGTCGTTTTT
TTCAACTCGGCGGACCGGAGAGATTGTGTCGCGGTTTGCGGATGCCAATAAAATTATTGATGCGCTGGCGAATACGATTA
TGACGTTGTTTTTGGATGTCTGGATTGTCCTAATATTAGGCATTGTTCTAGGGATCCAAAATGGGACTTTGTTTTTAGTG
TCATTGATTGCCGTGCCGTGTTACTTGGTGATTGTTTTTGCATTTCAGCGGCCGTTTGATCGGTTGAATCAAGAGACGAT
GGAAAGTAATGCAATCTTGAGTTCATCGATTATTGAAGATTTGAATGGCATTGAAACCATCAAGTCCTTGACCGGCGAAC
GAGTTAGCTATGAACGGGTTGATCGGGAATTTCTAACCTATTTGAAGAGGTCGTTTAGTTACACCAAGGCAGATCAGTTA
CAGCAAGCGATTAAAGGCCTGTTGAAGCTGGCGTTGAACGTTGTGGTGTTGTGGATTGGGGCAAGTTTGGTGATTGCCAA
TCGAATGAGTTTGGGGCAGATGCTGACCTTTAATGCGCTGCTGTCATACTTTACGAATCCGCTTGAAAGCATCATCAACC
TACAGCCAAAGTTACAAATGGCGCGGGTTGCTAACAATCGTTTGAATGAGGTTTATCTGGTTGAATCGGAATTCAAAGAA
CCGCGGCACTTGACGGAGCGGCATTTAATCGAAGGTCCGTTACGTGTTCGGGATGTTTCGTTTAAATATGGTTTTGGCCA
AGATGTGTTGAAAAACATCAACCTTGAAGTGCCGGAAAATGCTAAATATACCATTGTTGGCATGAGTGGTTCTGGTAAGT
CGACATTAGCAAAATTATTAGTTGGCTTTTACCCAGTTGATACCGATAAGGGAACCATCACGTTTAATGGCATTCCGGTC
AAAGACATTAATCTCACAACATTACGGCAATATATTGAATATGTACCTCAGGATCCATTTATTTTTTCGGGCACGGTGTT
GGAGAATTTGACGTTAGGTAGCCGTTCGGATGTTTCGGAACAAGACTTGACGCAGGCGTGTTTGGCTGCGGAAATTGCCG
CAGACATCGCAAACTTACCGCAGCAGTGGCAGACCAAATTGTCAGAAAGCGGCAGCATTTTATCAGGCGGTCAGAAGCAG
CGGCTGGCGATTGCACGGGCCTTGTTATCGCCGGCAAAAGTACTGATTTTTGACGAATCGACTAGCAGTCTGGATACCAT
TACAGAGCGAAAAATTGTCGATCGCTTGCTGGCAATGACGGATCGGACCATTATTTTTGTTGCCCATCGCTTAACTATTG
CGGCTAAAACCGAACAAATTGTGGTGATGGATCATGGCAAAATTGTGGAACAAGGTGACCATGCAACGTTGTTAGCCCAA
GACGGTTATTACGCGCGCCTGGTTCATGAGTGA

Domains

Predicted by InterproScan.

• ABC transporter (ABC_tran) (510-662)

• ABC transporter transmembrane region (ABC_membrane) (180-448)

• Peptidase C39 family (Peptidase_C39) (18-152)

3D structure

• AlphaFold DB: A0A809N5K4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comA	Streptococcus pneumoniae D39	58.182	97.945	0.57
comA	Streptococcus pneumoniae R6	58.182	97.945	0.57
comA	Streptococcus pneumoniae Rx1	58.182	97.945	0.57
comA	Streptococcus pneumoniae TIGR4	57.762	97.945	0.566
comA	Streptococcus mitis NCTC 12261	57.762	97.945	0.566
comA	Streptococcus mitis SK321	57.622	97.945	0.564
comA	Streptococcus gordonii str. Challis substr. CH1	56.467	98.493	0.556
comA/nlmT	Streptococcus mutans UA159	53.547	98.493	0.527