Detailed information NTG0914776

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: SC851_RS11005
• Genome accession: NZ_CP140606
• Coordinates: 2224080..2224841 (-)
• Length: 253 a.a.
• NCBI ID: WP_405257643.1
• Uniprot ID: -
• Organism: Ligilactobacillus murinus strain XYW20210915003
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
Genomic island	2214126..2224065	2224080..2224841	flank	15

Gene organization within MGE regions

Location: 2214126..2224841

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
SC851_RS10955 (SC851_10905)	-	2214126..2216147 (-)	2022	WP_129303372.1	heavy metal translocating P-type ATPase	-
SC851_RS10960 (SC851_10910)	-	2216167..2216616 (-)	450	WP_004050438.1	CopY/TcrY family copper transport repressor	-
SC851_RS10965 (SC851_10915)	-	2216806..2217978 (+)	1173	WP_004047661.1	IS256 family transposase	-
SC851_RS10970 (SC851_10920)	-	2218028..2218633 (-)	606	Protein_2108	methyltransferase domain-containing protein	-
SC851_RS10975 (SC851_10925)	-	2218626..2219486 (-)	861	WP_405257634.1	hypothetical protein	-
SC851_RS10980 (SC851_10930)	-	2219537..2220109 (+)	573	WP_405257637.1	transposase	-
SC851_RS10985 (SC851_10935)	-	2220081..2220458 (-)	378	WP_405257640.1	hypothetical protein	-
SC851_RS10990 (SC851_10940)	-	2220665..2221378 (-)	714	WP_004049931.1	ABC transporter permease	-
SC851_RS10995 (SC851_10945)	-	2221371..2222216 (-)	846	WP_004049928.1	ABC transporter ATP-binding protein	-
SC851_RS11000 (SC851_10950)	-	2222740..2224065 (-)	1326	WP_004049925.1	sensor histidine kinase	-
SC851_RS11005 (SC851_10955)	comE/blpR	2224080..2224841 (-)	762	WP_405257643.1	response regulator transcription factor	Regulator

Sequence

Protein

• Length: 253 a.a.
• Molecular weight: 28996.42 Da
• Isoelectric Point: 5.9838

>NTDB_id=914776 SC851_RS11005 WP_405257643.1 2224080..2224841(-) (comE/blpR) [Ligilactobacillus murinus strain XYW20210915003]
MSNLGGSLQINIFVLEDEILQQSRIETAILKILNEEQIKCRVFDVFGSSSQLLEAIEERGGHQLFFLDIEIKDEEKKGLE
IAKEIRKKDPAATIVFVTTHSEFMPLTFKFKVSALDFIDKALGEQYFYERIKSAIDYTLASAGETLSQESFHLETSLSQI
QVPLKKILYFETSPTVHKVILHTIDERIEFYATISEIEKKDSRLYRSHKSFVVNPANIERLDKVNKIIYFPNGDSCLVAR
TKLKGLSERITLL

Nucleotide

• Length: 762 bp

>NTDB_id=914776 SC851_RS11005 WP_405257643.1 2224080..2224841(-) (comE/blpR) [Ligilactobacillus murinus strain XYW20210915003]
TTGTCCAACTTAGGGGGTTCACTTCAGATCAATATTTTTGTACTTGAAGATGAGATACTTCAACAGTCTCGCATTGAAAC
GGCCATTCTAAAAATTTTAAACGAAGAACAGATAAAGTGTAGAGTTTTTGATGTTTTTGGAAGCTCTTCTCAATTGTTAG
AAGCTATTGAGGAGAGAGGGGGGCACCAGTTATTTTTCCTAGATATTGAAATTAAGGACGAGGAGAAAAAAGGACTGGAG
ATCGCTAAGGAGATCCGAAAAAAAGATCCCGCTGCGACTATCGTTTTTGTGACGACGCATTCGGAATTTATGCCACTAAC
ATTTAAATTTAAAGTTAGTGCTCTTGATTTTATCGATAAAGCTTTAGGAGAGCAATACTTCTATGAGCGTATTAAATCTG
CTATTGACTACACACTAGCTAGTGCTGGAGAAACGCTGTCTCAAGAATCATTTCATTTAGAAACGTCACTATCTCAAATA
CAAGTGCCTTTAAAAAAAATCCTGTATTTTGAAACATCCCCGACTGTACATAAGGTTATTTTGCATACGATCGATGAACG
AATTGAATTTTATGCAACGATCTCTGAGATCGAAAAAAAAGACAGCCGATTATATAGAAGCCATAAGTCATTTGTAGTAA
ATCCTGCTAACATTGAGCGTCTGGATAAGGTCAATAAGATCATTTATTTTCCAAATGGAGATTCTTGTTTAGTAGCACGA
ACAAAACTTAAAGGATTAAGTGAAAGGATTACATTATTGTAG

Domains

Predicted by InterproScan.

• LytTr DNA-binding domain (LytTR) (160-250)

• Response regulator receiver domain (Response_reg) (12-131)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	55.042	94.071	0.518
comE/comE1	Streptococcus equinus JB1	47.303	95.257	0.451
comE/comE2	Streptococcus equinus JB1	41.494	95.257	0.395
comE/comE2	Streptococcus gordonii strain NCTC7865	39.754	96.443	0.383
comE/comE1	Streptococcus gordonii str. Challis substr. CH1	39.754	96.443	0.383