Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   U0N78_RS11745 Genome accession   NZ_CP140109
Coordinates   2462602..2463798 (+) Length   398 a.a.
NCBI ID   WP_043024644.1    Uniprot ID   -
Organism   Streptococcus suis strain 2022WUSS148     
Function   require for competence development (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Prophage 2428934..2462428 2462602..2463798 flank 174


Gene organization within MGE regions


Location: 2428934..2463798
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  U0N78_RS11550 (U0N78_11550) - 2428934..2429488 (-) 555 WP_029174207.1 LysM peptidoglycan-binding domain-containing protein -
  U0N78_RS11555 (U0N78_11555) - 2429810..2430604 (-) 795 WP_002938197.1 energy-coupling factor transporter transmembrane component T family protein -
  U0N78_RS11560 (U0N78_11560) - 2430597..2431439 (-) 843 WP_043027190.1 energy-coupling factor transporter ATPase -
  U0N78_RS11565 (U0N78_11565) - 2431415..2432251 (-) 837 WP_043027191.1 energy-coupling factor ABC transporter ATP-binding protein -
  U0N78_RS11570 (U0N78_11570) pgsA 2432248..2432787 (-) 540 WP_002941818.1 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase -
  U0N78_RS11575 (U0N78_11575) rodZ 2432797..2433654 (-) 858 WP_043027192.1 cytoskeleton protein RodZ -
  U0N78_RS11580 (U0N78_11580) yfmH 2433736..2435019 (-) 1284 WP_043027193.1 EF-P 5-aminopentanol modification-associated protein YfmH -
  U0N78_RS11585 (U0N78_11585) yfmF 2435016..2436269 (-) 1254 WP_043027194.1 EF-P 5-aminopentanol modification-associated protein YfmF -
  U0N78_RS11590 (U0N78_11590) - 2436573..2436950 (-) 378 WP_002941801.1 type II toxin-antitoxin system HicB family antitoxin -
  U0N78_RS11595 (U0N78_11595) - 2436985..2437176 (-) 192 Protein_2252 type II toxin-antitoxin system HicA family toxin -
  U0N78_RS11600 (U0N78_11600) - 2437361..2437768 (-) 408 WP_043025519.1 ArpU family phage packaging/lysis transcriptional regulator -
  U0N78_RS11605 (U0N78_11605) - 2438047..2438622 (-) 576 WP_043025515.1 hypothetical protein -
  U0N78_RS11610 (U0N78_11610) - 2438619..2439413 (-) 795 WP_079395285.1 ATP-binding protein -
  U0N78_RS11615 (U0N78_11615) - 2439494..2440288 (-) 795 WP_043025513.1 phage replisome organizer N-terminal domain-containing protein -
  U0N78_RS11620 (U0N78_11620) - 2440275..2440556 (-) 282 WP_043025511.1 hypothetical protein -
  U0N78_RS11625 (U0N78_11625) - 2440549..2440923 (-) 375 WP_228475294.1 hypothetical protein -
  U0N78_RS11630 (U0N78_11630) - 2441040..2441252 (-) 213 WP_043025507.1 hypothetical protein -
  U0N78_RS11635 (U0N78_11635) - 2441245..2441457 (-) 213 WP_052496991.1 hypothetical protein -
  U0N78_RS11640 (U0N78_11640) - 2441447..2441779 (-) 333 WP_043025503.1 hypothetical protein -
  U0N78_RS11645 (U0N78_11645) - 2441941..2442267 (-) 327 WP_043025501.1 phage head closure protein -
  U0N78_RS11650 (U0N78_11650) - 2442283..2442909 (-) 627 WP_043025499.1 Rha family transcriptional regulator -
  U0N78_RS11655 (U0N78_11655) - 2442928..2443125 (-) 198 WP_002941765.1 helix-turn-helix domain-containing protein -
  U0N78_RS11660 (U0N78_11660) - 2443335..2443829 (+) 495 WP_079395284.1 helix-turn-helix transcriptional regulator -
  U0N78_RS11665 (U0N78_11665) - 2444625..2445770 (+) 1146 WP_043025498.1 tyrosine-type recombinase/integrase -
  U0N78_RS11670 (U0N78_11670) yaaA 2445868..2446251 (+) 384 WP_043025497.1 S4 domain-containing protein YaaA -
  U0N78_RS11675 (U0N78_11675) recF 2446254..2447348 (+) 1095 WP_043025496.1 DNA replication/repair protein RecF -
  U0N78_RS11680 (U0N78_11680) guaB 2447619..2449100 (-) 1482 WP_024418406.1 IMP dehydrogenase -
  U0N78_RS11685 (U0N78_11685) trpS 2449329..2450354 (-) 1026 WP_043025992.1 tryptophan--tRNA ligase -
  U0N78_RS11690 (U0N78_11690) - 2450711..2451583 (+) 873 WP_043025995.1 YitT family protein -
  U0N78_RS11695 (U0N78_11695) - 2451648..2453270 (+) 1623 WP_012775415.1 ABC-F family ATP-binding cassette domain-containing protein -
  U0N78_RS11700 (U0N78_11700) - 2453577..2456156 (+) 2580 WP_043025832.1 YfhO family protein -
  U0N78_RS11705 (U0N78_11705) - 2456574..2459078 (-) 2505 WP_043025830.1 SEC10/PgrA surface exclusion domain-containing protein -
  U0N78_RS11710 (U0N78_11710) - 2459225..2459560 (+) 336 WP_306172866.1 helix-turn-helix domain-containing protein -
  U0N78_RS11715 (U0N78_11715) - 2459663..2460736 (+) 1074 WP_043025828.1 site-specific integrase -
  U0N78_RS11735 (U0N78_11735) - 2461241..2461924 (-) 684 WP_043024643.1 YoaK family protein -
  U0N78_RS11740 (U0N78_11740) rlmH 2461949..2462428 (-) 480 WP_002941741.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  U0N78_RS11745 (U0N78_11745) htrA 2462602..2463798 (+) 1197 WP_043024644.1 S1C family serine protease Regulator

Sequence

Protein


Download         Length: 398 a.a.        Molecular weight: 41850.93 Da        Isoelectric Point: 4.5454

>NTDB_id=912600 U0N78_RS11745 WP_043024644.1 2462602..2463798(+) (htrA) [Streptococcus suis strain 2022WUSS148]
MERIPYMKKYLKFAILFVIGFFGGLIGALSASFFQPQVQQANSAITSVSNVQYNNETSTTKAVEKVQNAVVSVINYQKSA
NNSLGVIFGNIESSDELAVAGEGSGVIYKKDGQYAYIVTNTHVINNAEKIDILLASGEKISGELVGSDTYSDIAVIKISA
DKVTAVAEFADSDTIKVGETAIAIGSPLGSVYANTVTQGIISSLSRTVTSQSEDGQTISTNAIQTDTAINPGNSGGPLIN
IQGQVIGITSSKITSSSVSSSGVAVEGMGFAIPANDAVAIINQLEKAGKVSRPALGVHMVNLTTLSTSQLEKAGLSNTEL
TSGVVIVSTQSGLPADGKLETFDVITEIDGETIQNKSDLQSALYKHQIGDTITVTYYRNNQKQTVDIKLTHSTEELSE

Nucleotide


Download         Length: 1197 bp        

>NTDB_id=912600 U0N78_RS11745 WP_043024644.1 2462602..2463798(+) (htrA) [Streptococcus suis strain 2022WUSS148]
ATGGAAAGGATTCCTTATATGAAAAAATATTTGAAATTTGCGATTTTATTTGTAATTGGATTTTTTGGGGGTCTTATCGG
AGCCTTATCAGCCTCTTTCTTCCAACCACAGGTGCAACAAGCAAATTCTGCTATCACTAGTGTCAGCAATGTTCAATATA
ATAATGAAACTTCCACCACAAAAGCTGTAGAGAAAGTACAAAATGCTGTTGTGTCTGTTATTAATTACCAAAAATCAGCC
AACAATAGTCTTGGTGTTATCTTTGGAAATATTGAATCATCTGACGAACTAGCCGTTGCTGGGGAGGGATCTGGTGTTAT
CTACAAAAAAGATGGTCAATATGCCTATATTGTGACAAATACGCATGTCATTAATAACGCAGAAAAGATTGATATTCTTT
TAGCATCTGGAGAAAAAATTAGCGGTGAACTCGTTGGTTCCGATACCTATTCTGATATAGCTGTTATAAAAATATCAGCA
GATAAAGTCACTGCTGTTGCTGAATTTGCTGATTCCGATACAATTAAAGTTGGAGAAACTGCTATCGCAATTGGTAGTCC
TCTAGGTAGCGTCTACGCTAATACAGTTACTCAAGGTATTATTTCTAGCCTAAGTCGGACAGTTACTTCACAATCAGAAG
ATGGTCAAACAATCTCAACCAACGCTATTCAAACCGATACAGCTATCAACCCTGGAAACTCTGGAGGACCATTGATTAAT
ATCCAAGGACAAGTTATTGGTATCACCTCTAGCAAAATCACCTCAAGTTCTGTAAGTAGCTCAGGGGTGGCTGTGGAAGG
GATGGGATTCGCTATTCCTGCAAATGATGCCGTAGCCATTATCAATCAACTTGAGAAAGCTGGAAAAGTTAGCCGACCTG
CTCTTGGAGTTCATATGGTTAACTTGACGACCTTGTCAACTAGTCAATTAGAAAAAGCTGGATTATCAAATACGGAATTA
ACATCCGGTGTCGTAATTGTCTCTACACAAAGTGGACTACCTGCAGATGGAAAATTAGAAACTTTTGATGTCATTACTGA
GATTGACGGAGAAACTATTCAAAATAAGAGTGACCTCCAGAGCGCTCTCTACAAACATCAAATTGGAGATACAATCACTG
TAACTTATTACCGCAATAATCAGAAACAAACTGTTGACATTAAGTTGACACATTCTACAGAAGAACTTAGCGAATAA

Domains

Predicted by InterproScan.

PDZ domain (PDZ_2)

(293-389)

Trypsin-like peptidase domain (Trypsin_2)

(103-248)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus mutans UA159

60.453

99.749

0.603
  htrA Streptococcus gordonii str. Challis substr. CH1

60.253

99.246

0.598
  htrA Streptococcus pneumoniae D39

57.506

98.744

0.568
  htrA Streptococcus pneumoniae TIGR4

57.506

98.744

0.568
  htrA Streptococcus mitis NCTC 12261

57.506

98.744

0.568
  htrA Streptococcus pneumoniae R6

57.506

98.744

0.568
  htrA Streptococcus pneumoniae Rx1

57.506

98.744

0.568