Detailed information NTG0091255

Bioinformatically predicted

Overview

• Name: mecA
• Type: Regulator
• Locus tag: L6411_RS08405
• Genome accession: NZ_AP025333
• Coordinates: 1750358..1751080 (-)
• Length: 240 a.a.
• NCBI ID: WP_024531872.1
• Uniprot ID: A0A2Z5TQ77
• Organism: Streptococcus ruminantium strain GUT-189
• Function: degradation of ComW (predicted from homology) Competence regulation

Genomic Context

Location: 1745358..1756080

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
L6411_RS08380 (GUT189_16190)	sufU	1745401..1745841 (-)	441	WP_120172171.1	Fe-S cluster assembly sulfur transfer protein SufU	-
L6411_RS08385 (GUT189_16200)	-	1745828..1747054 (-)	1227	WP_237374066.1	cysteine desulfurase	-
L6411_RS08390 (GUT189_16210)	sufD	1747056..1748318 (-)	1263	WP_237374067.1	Fe-S cluster assembly protein SufD	-
L6411_RS08395 (GUT189_16220)	sufC	1748335..1749108 (-)	774	WP_024531874.1	Fe-S cluster assembly ATPase SufC	-
L6411_RS08400 (GUT189_16230)	-	1749201..1750361 (-)	1161	WP_120172178.1	glycosyltransferase family 4 protein	-
L6411_RS08405 (GUT189_16240)	mecA	1750358..1751080 (-)	723	WP_024531872.1	adaptor protein MecA	Regulator
L6411_RS08410 (GUT189_16250)	-	1751291..1752127 (-)	837	WP_155964977.1	undecaprenyl-diphosphate phosphatase	-
L6411_RS08415 (GUT189_16260)	-	1752260..1753822 (+)	1563	WP_156021675.1	ABC transporter substrate-binding protein/permease	-
L6411_RS08420 (GUT189_16270)	-	1753815..1754558 (+)	744	WP_155962430.1	amino acid ABC transporter ATP-binding protein	-
L6411_RS08425 (GUT189_16280)	-	1754804..1755013 (-)	210	WP_024531868.1	hypothetical protein	-
L6411_RS08430 (GUT189_16290)	-	1755099..1755998 (-)	900	WP_024531867.1	SPFH domain-containing protein	-

Sequence

Protein

• Length: 240 a.a.
• Molecular weight: 28012.59 Da
• Isoelectric Point: 4.1200

>NTDB_id=91255 L6411_RS08405 WP_024531872.1 1750358..1751080(-) (mecA) [Streptococcus ruminantium strain GUT-189]
MKVKQISDSTLKITIKLDDLEERGMELSDFLIPQEKTEEFFYTVLDELDLPMTFRESGMLSFRVTPKPDRVDIFVTKSDL
DQNLNFDEFTDLSDLGDVASMTPDEFFKSLEQTVREKSAADVAAVHHLEDIEQAEEDEDGEQERYIYYILEFKKIEELFI
FVGTVDYSIEESELYKMDGYYYLTVLVDIENRSKQYPEHLLSRMLEFSNDTKLARPVLQEHGMLLLSHAAIEELRKVTIA

Nucleotide

• Length: 723 bp

>NTDB_id=91255 L6411_RS08405 WP_024531872.1 1750358..1751080(-) (mecA) [Streptococcus ruminantium strain GUT-189]
ATGAAAGTAAAGCAAATTAGTGATTCTACCTTAAAAATCACTATCAAATTGGATGACTTGGAAGAAAGAGGCATGGAACT
TTCTGACTTTCTTATCCCACAGGAGAAGACAGAAGAGTTTTTCTACACAGTTCTGGATGAGCTGGACTTGCCGATGACTT
TCCGCGAAAGTGGTATGCTGAGTTTCCGTGTGACACCAAAGCCTGATAGGGTTGACATTTTTGTGACCAAATCTGATTTG
GATCAAAATTTGAATTTTGATGAATTTACAGATTTGTCTGACCTTGGTGATGTTGCCAGCATGACTCCAGATGAATTTTT
CAAGAGTTTGGAGCAGACGGTTCGTGAGAAGAGTGCCGCAGATGTAGCTGCTGTCCACCATCTAGAAGATATTGAGCAGG
CAGAAGAGGATGAGGACGGAGAGCAAGAACGGTATATCTACTACATTTTAGAGTTCAAAAAGATTGAAGAACTATTTATT
TTTGTTGGTACGGTTGACTATTCGATTGAAGAATCGGAACTTTATAAGATGGATGGTTACTATTATCTGACAGTTCTTGT
TGATATAGAAAACCGTTCCAAGCAATATCCAGAGCACCTTCTTTCACGTATGTTAGAGTTTTCCAACGATACAAAATTAG
CAAGACCTGTCTTGCAAGAACACGGGATGCTCCTCCTCTCCCATGCAGCGATTGAAGAGCTTAGAAAGGTTACAATAGCA
TGA

Domains

Predicted by InterproScan.

• Negative regulator of genetic competence (MecA) (MecA) (1-234)

3D structure

• AlphaFold DB: A0A2Z5TQ77

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
mecA	Streptococcus pneumoniae Rx1	55.328	100	0.563
mecA	Streptococcus pneumoniae D39	55.328	100	0.563
mecA	Streptococcus pneumoniae R6	55.328	100	0.563
mecA	Streptococcus pneumoniae TIGR4	55.328	100	0.563
mecA	Streptococcus mutans UA159	50	100	0.508
mecA	Streptococcus thermophilus LMD-9	46.586	100	0.483
mecA	Streptococcus thermophilus LMG 18311	46.185	100	0.479