Detailed information    

insolico Bioinformatically predicted

Overview

Name   mecA   Type   Regulator
Locus tag   U0450_RS09900 Genome accession   NZ_CP139863
Coordinates   1907070..1907807 (+) Length   245 a.a.
NCBI ID   WP_000782689.1    Uniprot ID   -
Organism   Streptococcus pneumoniae strain 15P2112     
Function   degradation of ComW (predicted from homology)   
Competence regulation

Genomic Context

Location: 1902070..1912807
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  U0450_RS09880 - 1902267..1903370 (+) 1104 WP_000225904.1 glycosyltransferase -
  U0450_RS09885 - 1903372..1904358 (+) 987 WP_050072575.1 glycosyltransferase family 2 protein -
  U0450_RS09890 - 1904374..1905807 (+) 1434 WP_000565082.1 O-antigen polysaccharide polymerase Wzy family protein -
  U0450_RS09895 - 1905836..1906870 (+) 1035 WP_000461498.1 hypothetical protein -
  U0450_RS09900 mecA 1907070..1907807 (+) 738 WP_000782689.1 adaptor protein MecA Regulator
  U0450_RS09905 - 1907958..1909244 (+) 1287 WP_050212646.1 homoserine dehydrogenase -
  U0450_RS09910 thrB 1909246..1910115 (+) 870 WP_000692438.1 homoserine kinase -
  U0450_RS09915 - 1910191..1910343 (+) 153 WP_224781581.1 chlorohydrolase -
  U0450_RS09920 msrB 1910410..1911348 (+) 939 WP_000818204.1 peptide-methionine (R)-S-oxide reductase MsrB -

Sequence

Protein


Download         Length: 245 a.a.        Molecular weight: 28380.20 Da        Isoelectric Point: 4.0385

>NTDB_id=911604 U0450_RS09900 WP_000782689.1 1907070..1907807(+) (mecA) [Streptococcus pneumoniae strain 15P2112]
MKMKQISDTTLKITMSLEDLMDRGMEIADFLVPQEKTEEFFYAILDELEMPDSFLDTGMLSFRVTPKPDKVDVFVTKSKI
DQNLDFENLSDLPDMEELAQMSPDEFIKTLEKSIADKTKDDIEAIQSLEQVEAKEEEQEQAEQEAESKKEPYIYYILSFA
KLADLVAFAKTVTFEMETSELYKMNERYYLTILVDIENHPSPYPAWLLARMREFADDSDISRSVLQEYGQVLMSHDAVLN
LQKIG

Nucleotide


Download         Length: 738 bp        

>NTDB_id=911604 U0450_RS09900 WP_000782689.1 1907070..1907807(+) (mecA) [Streptococcus pneumoniae strain 15P2112]
ATGAAAATGAAACAAATTAGTGATACAACTTTAAAAATCACGATGTCTTTAGAGGATTTGATGGATCGTGGAATGGAGAT
TGCTGACTTTCTCGTTCCTCAAGAAAAAACAGAAGAGTTCTTTTATGCTATCTTGGATGAGCTAGAGATGCCTGATAGCT
TTCTGGATACAGGCATGTTGAGCTTCCGTGTGACTCCAAAACCTGATAAGGTAGATGTCTTTGTGACCAAGTCAAAGATT
GACCAAAATCTAGATTTTGAAAACTTATCGGATTTGCCAGATATGGAAGAATTGGCTCAAATGTCTCCAGATGAATTTAT
CAAAACCCTGGAAAAAAGCATCGCAGACAAAACCAAGGATGATATCGAAGCCATTCAATCTCTTGAGCAAGTTGAAGCCA
AGGAAGAAGAGCAAGAGCAGGCTGAACAAGAAGCTGAGAGTAAGAAAGAACCTTACATCTACTACATCCTTTCTTTTGCT
AAGTTGGCTGACTTGGTAGCTTTTGCCAAGACAGTGACTTTTGAAATGGAAACTTCTGAACTCTACAAAATGAACGAGCG
CTATTATTTGACCATTTTAGTGGATATTGAAAATCATCCAAGCCCATATCCAGCTTGGCTGTTGGCCCGTATGCGCGAGT
TTGCAGACGATAGTGATATCAGTCGCTCAGTCTTACAAGAGTATGGTCAAGTCTTGATGAGTCACGATGCAGTGCTCAAT
CTGCAAAAAATCGGCTAA

Domains

Predicted by InterproScan.

Negative regulator of genetic competence (MecA) (MecA)

(1-239)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  mecA Streptococcus pneumoniae Rx1

99.184

100

0.992
  mecA Streptococcus pneumoniae D39

99.184

100

0.992
  mecA Streptococcus pneumoniae R6

99.184

100

0.992
  mecA Streptococcus pneumoniae TIGR4

98.776

100

0.988
  mecA Streptococcus thermophilus LMD-9

47.39

100

0.482
  mecA Streptococcus thermophilus LMG 18311

46.988

100

0.478
  mecA Streptococcus mutans UA159

47.755

100

0.478