Detailed information    

insolico Bioinformatically predicted

Overview

Name   micA   Type   Regulator
Locus tag   U0449_RS09920 Genome accession   NZ_CP139862
Coordinates   1926699..1927403 (+) Length   234 a.a.
NCBI ID   WP_000722076.1    Uniprot ID   Q9S1K0
Organism   Streptococcus pneumoniae strain 05H0020-2     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 1921699..1932403
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  U0449_RS09895 coaC 1922057..1922608 (-) 552 WP_322397713.1 phosphopantothenoylcysteine decarboxylase -
  U0449_RS09900 coaB 1922620..1923309 (-) 690 WP_322397715.1 phosphopantothenate--cysteine ligase -
  U0449_RS09905 - 1923539..1925209 (+) 1671 WP_322397717.1 formate--tetrahydrofolate ligase -
  U0449_RS09910 - 1925247..1925372 (-) 126 WP_001818232.1 hypothetical protein -
  U0449_RS09915 mutY 1925469..1926644 (+) 1176 WP_000886147.1 A/G-specific adenine glycosylase -
  U0449_RS09920 micA 1926699..1927403 (+) 705 WP_000722076.1 response regulator YycF Regulator
  U0449_RS09925 micB 1927396..1928745 (+) 1350 WP_000886210.1 cell wall metabolism sensor histidine kinase VicK Regulator
  U0449_RS09930 vicX 1928747..1929556 (+) 810 WP_001289493.1 MBL fold metallo-hydrolase Regulator
  U0449_RS09935 relB 1929647..1929889 (+) 243 WP_000208080.1 type II toxin-antitoxin system RelB family antitoxin -
  U0449_RS09940 - 1929891..1930145 (+) 255 WP_001809704.1 type II toxin-antitoxin system RelE/ParE family toxin -
  U0449_RS09945 - 1930192..1930965 (+) 774 WP_000731132.1 ion transporter -
  U0449_RS09950 - 1931228..1932214 (-) 987 WP_000204727.1 L-lactate dehydrogenase -

Sequence

Protein


Download         Length: 234 a.a.        Molecular weight: 26815.63 Da        Isoelectric Point: 4.7164

>NTDB_id=911529 U0449_RS09920 WP_000722076.1 1926699..1927403(+) (micA) [Streptococcus pneumoniae strain 05H0020-2]
MKKILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKTSSVPILMLSA
KDSEFDKVIGLELGADDYVTKPFSNRELQARVKALLRRSQPMPVDGQEADSKPQPIQIGDLEIVPDAYVAKKYGEELDLT
HREFELLYHLASHTGQVITREHLLETVWGYDYFGDVRTVDVTVRRLREKIEDTPSRPEYILTRRGVGYYMRNNA

Nucleotide


Download         Length: 705 bp        

>NTDB_id=911529 U0449_RS09920 WP_000722076.1 1926699..1927403(+) (micA) [Streptococcus pneumoniae strain 05H0020-2]
ATGAAAAAAATACTAATTGTAGATGATGAGAAACCAATCTCGGATATTATCAAGTTTAATATGACCAAGGAAGGTTACGA
AGTTGTAACTGCTTTTAATGGTCGTGAAGCGCTAGAGCAATTTGAAGCAGAGCAACCAGATATTATTATTCTGGATTTGA
TGCTTCCAGAAATTGATGGTTTAGAAGTTGCTAAGACCATTCGTAAGACAAGCAGTGTGCCCATTCTTATGCTTTCAGCC
AAAGATAGTGAATTTGATAAGGTTATCGGTTTGGAACTTGGGGCAGATGACTATGTAACGAAACCCTTCTCCAATCGTGA
GTTGCAGGCGCGTGTTAAAGCTCTTCTGCGTCGTTCTCAACCTATGCCAGTAGATGGGCAGGAAGCAGATAGTAAACCTC
AACCTATCCAAATTGGGGATTTAGAAATTGTTCCAGACGCCTACGTGGCTAAAAAATATGGCGAAGAACTAGACTTAACC
CATCGTGAATTTGAGCTTTTGTATCATTTAGCATCGCATACAGGTCAAGTCATCACGCGCGAACACTTGCTTGAGACTGT
CTGGGGTTATGACTATTTTGGTGATGTCCGTACAGTTGATGTGACTGTACGACGTCTGCGTGAGAAGATTGAAGATACGC
CCAGCCGACCAGAGTATATCTTGACGCGCCGTGGTGTAGGGTATTACATGAGAAATAATGCTTGA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(4-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(154-229)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  PDB 1NXS
  PDB 2A9O
  PDB 2A9P

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  micA Streptococcus pneumoniae Cp1015

100

100

1
  vicR Streptococcus mutans UA159

78.541

99.573

0.782
  covR Streptococcus salivarius strain HSISS4

44.156

98.718

0.436
  covR Lactococcus lactis subsp. lactis strain DGCC12653

43.478

98.291

0.427
  scnR Streptococcus mutans UA159

38.197

99.573

0.38