Detailed information    

insolico Bioinformatically predicted

Overview

Name   mecA   Type   Regulator
Locus tag   U0449_RS09500 Genome accession   NZ_CP139862
Coordinates   1840701..1841438 (+) Length   245 a.a.
NCBI ID   WP_000782677.1    Uniprot ID   A0A0U0DTC6
Organism   Streptococcus pneumoniae strain 05H0020-2     
Function   degradation of ComW (predicted from homology)   
Competence regulation

Genomic Context

Location: 1835701..1846438
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  U0449_RS09480 - 1835898..1837001 (+) 1104 WP_174222183.1 glycosyltransferase -
  U0449_RS09485 - 1837003..1837989 (+) 987 WP_000446980.1 glycosyltransferase family 2 protein -
  U0449_RS09490 - 1838005..1839438 (+) 1434 WP_000565089.1 O-antigen polysaccharide polymerase Wzy family protein -
  U0449_RS09495 - 1839467..1840501 (+) 1035 WP_000461498.1 hypothetical protein -
  U0449_RS09500 mecA 1840701..1841438 (+) 738 WP_000782677.1 adaptor protein MecA Regulator
  U0449_RS09505 - 1841589..1842875 (+) 1287 WP_000216380.1 homoserine dehydrogenase -
  U0449_RS09510 thrB 1842877..1843746 (+) 870 WP_050218893.1 homoserine kinase -
  U0449_RS09515 - 1843822..1844019 (+) 198 WP_025169195.1 hypothetical protein -
  U0449_RS09520 msrB 1844086..1845024 (+) 939 WP_000818207.1 peptide-methionine (R)-S-oxide reductase MsrB -

Sequence

Protein


Download         Length: 245 a.a.        Molecular weight: 28395.21 Da        Isoelectric Point: 4.0236

>NTDB_id=911527 U0449_RS09500 WP_000782677.1 1840701..1841438(+) (mecA) [Streptococcus pneumoniae strain 05H0020-2]
MKMKQISDTTLKITMSLEDLMDRGMEIADFLVPQEKTEEFFYAILDELEMPDSFLDTGMLSFRVTPKPDKVDVFVTKSKI
DQNLDFEDLSDLPDMEELAQMSPDEFIKTLEKSIADKTKDDIEAIQSLEQVEAKEEEQEQAEQEAESKKEPYIYYILSFA
KLADLVAFAKTVTFEMETSELYKMNERYYLTILVDIENHPSPYPAWLLARMREFAEDSDISRSVLQEYGQVLMSHDAVLN
LQKIG

Nucleotide


Download         Length: 738 bp        

>NTDB_id=911527 U0449_RS09500 WP_000782677.1 1840701..1841438(+) (mecA) [Streptococcus pneumoniae strain 05H0020-2]
ATGAAAATGAAACAAATTAGTGATACAACTTTAAAAATCACGATGTCTTTAGAGGATTTGATGGATCGTGGAATGGAGAT
TGCTGACTTTCTCGTTCCTCAAGAAAAAACAGAAGAGTTCTTTTATGCTATCTTGGATGAGCTAGAGATGCCTGATAGCT
TTCTGGATACAGGCATGTTGAGCTTCCGTGTGACTCCAAAACCTGATAAGGTAGATGTCTTTGTGACCAAGTCAAAGATT
GACCAAAATCTAGATTTTGAAGACTTATCGGATTTGCCAGATATGGAAGAATTGGCTCAAATGTCTCCAGATGAATTTAT
CAAAACCCTGGAAAAAAGCATCGCAGACAAAACCAAGGATGATATCGAAGCCATTCAATCTCTTGAGCAAGTTGAAGCCA
AGGAAGAAGAGCAAGAGCAGGCTGAACAAGAAGCTGAGAGTAAGAAAGAACCTTACATCTACTACATCCTTTCTTTTGCT
AAGTTGGCTGACTTGGTAGCTTTTGCCAAGACAGTGACTTTTGAAATGGAAACTTCTGAACTCTACAAAATGAACGAGCG
CTATTATTTGACCATTTTAGTGGATATTGAAAATCATCCAAGCCCATATCCAGCTTGGCTGTTGGCCCGTATGCGCGAGT
TTGCAGAGGATAGTGATATCAGTCGCTCAGTCTTACAAGAGTATGGTCAAGTCTTGATGAGTCACGATGCAGTGCTCAAT
CTGCAAAAAATCGGCTAA

Domains

Predicted by InterproScan.

Negative regulator of genetic competence (MecA) (MecA)

(1-239)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0U0DTC6

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  mecA Streptococcus pneumoniae Rx1

99.184

100

0.992
  mecA Streptococcus pneumoniae D39

99.184

100

0.992
  mecA Streptococcus pneumoniae R6

99.184

100

0.992
  mecA Streptococcus pneumoniae TIGR4

98.776

100

0.988
  mecA Streptococcus thermophilus LMD-9

47.791

100

0.486
  mecA Streptococcus thermophilus LMG 18311

47.39

100

0.482
  mecA Streptococcus mutans UA159

48.163

100

0.482