Detailed information    

insolico Bioinformatically predicted

Overview

Name   comA   Type   Regulator
Locus tag   U0449_RS04960 Genome accession   NZ_CP139862
Coordinates   983685..985838 (-) Length   717 a.a.
NCBI ID   WP_000668303.1    Uniprot ID   -
Organism   Streptococcus pneumoniae strain 05H0020-2     
Function   processing and transport of ComC (predicted from homology)   
Competence regulation

Genomic Context

Location: 978685..990838
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  U0449_RS04945 - 981301..981444 (-) 144 WP_050167432.1 hypothetical protein -
  U0449_RS04950 purC 981446..982153 (-) 708 WP_000043306.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
  U0449_RS04955 comB 982323..983672 (-) 1350 WP_000801617.1 competence pheromone export protein ComB Regulator
  U0449_RS04960 comA 983685..985838 (-) 2154 WP_000668303.1 peptide cleavage/export ABC transporter ComA Regulator
  U0449_RS04965 - 986425..986550 (-) 126 WP_000346297.1 PncF family bacteriocin immunity protein -
  U0449_RS04970 blpU 986553..986783 (-) 231 Protein_990 bacteriocin-like peptide BlpU -
  U0449_RS04975 - 986986..987286 (-) 301 Protein_991 transposase family protein -
  U0449_RS04980 - 987323..987556 (-) 234 WP_000659556.1 acyl carrier protein -
  U0449_RS04985 plsX 987562..988554 (-) 993 WP_000717452.1 phosphate acyltransferase PlsX -
  U0449_RS04990 recO 988551..989321 (-) 771 WP_000616162.1 DNA repair protein RecO -
  U0449_RS04995 - 989318..990487 (-) 1170 WP_000366347.1 pyridoxal phosphate-dependent aminotransferase -

Sequence

Protein


Download         Length: 717 a.a.        Molecular weight: 80406.50 Da        Isoelectric Point: 6.2590

>NTDB_id=911475 U0449_RS04960 WP_000668303.1 983685..985838(-) (comA) [Streptococcus pneumoniae strain 05H0020-2]
MKFGKRHYRPQVDQMDCGVASLAMVFGYYGSYYFLAHLRELAKTTMDGTTALGLVKVAEEIGFETRAIKADMTLFDLPDL
TFPFVAHVLKEGKLLHYYVVTGQDKDSIHIADPDPGVKLTKLPRERFEEEWTGVTLFMAPSPDYKPYKEQKNGLLSFIPI
LVKQRGLIANIVLATLLVTVINIVGSYYLQSIIDTYVPDQMRSTLGIISIGLVIVYILQQILSYAQEYLLLVLGQRLSID
VILSYIKHVFHLPMSFFATRRTGEIVSRFTDANSIIDALASTILSIFLDVSTVVIISLVLFSQNTNLFFMTLLALPIYTV
IIFAFMKPFEKMNRDTMEANAVLSSSIIEDINGIETIKSLTSESQRYQKIDKEFVDYLKKSFTYSRAESQQKALKKVAHL
LLNVGILWMGAVLVMDGKMSLGQLITYNTLLVYFTNPLENIINLQTKLQTAQVANNRLNEVYLVASEFEEKKTVEDLSLM
KGDMTFKQVHYKYGYGRDVLSDINLIVPQGSKVAFVGISGSGKTTLAKMMVNFYDPSQGEISLGGVNLNQIDKKALRQYI
NYLPQQPYVFNGTILENLLLGAKEGTTQEDILRAVELAEIREDIERMPLNYQTELTSDGAGISGGQRQRIALARALLTDA
PVLILDEATSSLDILTEKRIVDNLMALDKTLIFIAHRLTIAERTEKVVVLDQGKIVEEGKHADLLAQGGFYAHLVNS

Nucleotide


Download         Length: 2154 bp        

>NTDB_id=911475 U0449_RS04960 WP_000668303.1 983685..985838(-) (comA) [Streptococcus pneumoniae strain 05H0020-2]
ATGAAATTTGGGAAACGTCACTATCGTCCGCAAGTGGATCAGATGGACTGCGGTGTAGCTTCATTAGCCATGGTTTTTGG
CTACTATGGTAGTTATTATTTTTTGGCTCACTTGCGAGAATTGGCTAAGACGACCATGGATGGGACGACGGCTTTGGGCT
TGGTCAAGGTGGCAGAGGAGATTGGTTTTGAGACGCGAGCCATTAAGGCGGATATGACGCTTTTTGACTTGCCGGATTTG
ACTTTTCCTTTTGTTGCCCATGTGCTTAAGGAAGGGAAATTGCTCCACTACTATGTGGTGACTGGGCAGGATAAGGATAG
CATTCATATTGCCGATCCAGATCCCGGGGTGAAGTTGACTAAACTGCCACGTGAGCGTTTTGAGGAAGAATGGACAGGAG
TGACTCTTTTTATGGCACCTAGTCCAGACTATAAGCCTTATAAGGAACAAAAAAATGGTCTGCTCTCTTTTATCCCTATA
TTAGTGAAGCAGCGTGGCTTGATTGCCAATATCGTTTTGGCAACACTCTTGGTAACCGTGATTAACATTGTGGGTTCTTA
TTATCTGCAGTCTATCATTGATACCTATGTGCCAGATCAGATGCGTTCGACACTAGGGATTATTTCTATTGGGCTAGTCA
TCGTCTACATCCTCCAGCAAATCTTGTCTTACGCTCAGGAGTATCTCTTGCTTGTTTTGGGGCAACGCTTGTCGATTGAC
GTGATTTTGTCCTATATCAAGCATGTTTTTCACCTCCCTATGTCCTTTTTCGCGACACGCAGGACAGGGGAAATTGTGTC
TCGTTTCACGGATGCTAACAGTATTATCGATGCGCTGGCTTCGACCATTCTTTCGATTTTCCTAGATGTGTCAACAGTTG
TCATTATTTCCCTTGTTTTATTTTCACAAAATACCAATCTCTTTTTCATGACTTTATTGGCGCTTCCTATCTACACAGTG
ATTATCTTTGCCTTTATGAAGCCGTTTGAAAAGATGAATCGGGACACCATGGAAGCCAATGCGGTTCTGTCTTCTTCTAT
CATTGAGGACATCAACGGTATTGAGACTATCAAGTCCTTGACCAGTGAAAGTCAGCGTTACCAAAAAATTGACAAGGAAT
TTGTGGATTATCTGAAGAAATCCTTTACCTATAGTCGAGCAGAGAGTCAGCAAAAGGCTCTGAAAAAGGTTGCCCATCTC
TTACTTAATGTCGGCATTCTCTGGATGGGGGCTGTTCTGGTCATGGATGGCAAGATGAGTTTGGGGCAGTTGATTACCTA
TAATACCTTGCTGGTTTACTTTACCAATCCTTTGGAAAATATCATCAATCTGCAAACCAAGCTTCAGACAGCGCAGGTTG
CCAATAACCGTCTAAATGAAGTGTATCTAGTAGCTTCTGAGTTTGAGGAGAAGAAAACAGTTGAGGATTTGAGCTTGATG
AAGGGAGATATGACCTTCAAGCAGGTTCATTACAAGTATGGCTATGGTCGAGACGTCTTGTCGGATATCAATTTAATCGT
TCCCCAAGGGTCTAAGGTGGCTTTTGTGGGGATTTCAGGGTCAGGTAAGACGACTTTGGCCAAGATGATGGTTAATTTTT
ACGACCCAAGTCAAGGGGAGATTAGTCTGGGTGGTGTCAATCTCAATCAGATTGATAAAAAAGCCCTGCGCCAGTACATC
AACTATCTGCCTCAACAGCCCTATGTCTTTAACGGAACGATTTTGGAGAATCTTCTTTTGGGAGCCAAGGAGGGGACGAC
ACAGGAAGATATCTTACGGGCGGTCGAATTGGCAGAGATTCGAGAGGATATCGAGCGCATGCCACTGAATTACCAGACAG
AATTGACTTCGGATGGGGCAGGGATTTCAGGTGGTCAACGTCAGAGAATCGCTTTGGCGCGTGCTCTCTTGACAGATGCG
CCGGTCTTGATTTTGGATGAGGCGACTAGCAGTTTGGATATTTTGACAGAGAAGCGGATTGTCGATAATCTCATGGCTTT
AGACAAGACCTTGATTTTCATTGCTCACCGCTTGACTATTGCTGAGCGGACAGAGAAGGTAGTTGTCTTGGATCAGGGCA
AGATTGTCGAAGAAGGAAAGCATGCTGATTTGCTTGCACAGGGTGGCTTTTACGCCCATTTGGTCAATAGCTAG

Domains

Predicted by InterproScan.

Peptidase C39 family (Peptidase_C39)

(7-142)

ABC transporter (ABC_tran)

(500-650)

ABC transporter transmembrane region (ABC_membrane)

(170-438)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comA Streptococcus pneumoniae Rx1

99.582

100

0.996
  comA Streptococcus pneumoniae D39

99.582

100

0.996
  comA Streptococcus pneumoniae R6

99.582

100

0.996
  comA Streptococcus pneumoniae TIGR4

99.163

100

0.992
  comA Streptococcus mitis SK321

98.326

100

0.983
  comA Streptococcus mitis NCTC 12261

98.326

100

0.983
  comA Streptococcus gordonii str. Challis substr. CH1

80.753

100

0.808
  comA/nlmT Streptococcus mutans UA159

64.714

100

0.647