Detailed information    

insolico Bioinformatically predicted

Overview

Name   mecA   Type   Regulator
Locus tag   U0448_RS09525 Genome accession   NZ_CP139860
Coordinates   1865433..1866170 (+) Length   245 a.a.
NCBI ID   WP_000782676.1    Uniprot ID   A0A064C3U8
Organism   Streptococcus pneumoniae strain 21011     
Function   degradation of ComW (predicted from homology)   
Competence regulation

Genomic Context

Location: 1860433..1871170
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  U0448_RS09505 - 1860688..1861791 (+) 1104 WP_180377045.1 glycosyltransferase -
  U0448_RS09510 - 1861793..1862779 (+) 987 WP_000446980.1 glycosyltransferase family 2 protein -
  U0448_RS09515 - 1862795..1864228 (+) 1434 WP_000565082.1 O-antigen polysaccharide polymerase Wzy family protein -
  U0448_RS09520 - 1864257..1865291 (+) 1035 WP_000461502.1 hypothetical protein -
  U0448_RS09525 mecA 1865433..1866170 (+) 738 WP_000782676.1 adaptor protein MecA Regulator
  U0448_RS09530 - 1866321..1867607 (+) 1287 WP_000216382.1 homoserine dehydrogenase -
  U0448_RS09535 thrB 1867609..1868478 (+) 870 WP_000692438.1 homoserine kinase -
  U0448_RS09540 - 1868554..1868706 (+) 153 WP_001835993.1 hypothetical protein -
  U0448_RS09545 msrB 1868773..1869711 (+) 939 WP_000818203.1 peptide-methionine (R)-S-oxide reductase MsrB -

Sequence

Protein


Download         Length: 245 a.a.        Molecular weight: 28381.18 Da        Isoelectric Point: 4.0199

>NTDB_id=911372 U0448_RS09525 WP_000782676.1 1865433..1866170(+) (mecA) [Streptococcus pneumoniae strain 21011]
MKMKQISDTTLKITMSLEDLMDRGMEIADFLVPQEKTEEFFYAILDELEMPDSFLDTGMLSFRVTPKPDKVDVFVTKSKI
DQNLDFEDLSDLPDMEELAQMSPDEFIKTLEKSIADKTKDDIEAIQSLEQVEAKEEEQEQAEQEAESKKEPYIYYILSFA
KLADLVAFAKTVTFEMETSELYKMNERYYLTILVDIENHPSPYPAWLLARMREFADDSDISRSVLQEYGQVLMSHDAVLN
LQKIG

Nucleotide


Download         Length: 738 bp        

>NTDB_id=911372 U0448_RS09525 WP_000782676.1 1865433..1866170(+) (mecA) [Streptococcus pneumoniae strain 21011]
ATGAAAATGAAACAAATTAGTGATACAACTTTAAAAATCACGATGTCTTTAGAGGATTTGATGGATCGTGGAATGGAGAT
TGCTGACTTTCTCGTTCCTCAAGAAAAAACAGAAGAGTTCTTTTATGCTATCTTGGATGAGCTAGAGATGCCTGATAGCT
TTCTGGATACAGGCATGTTGAGCTTCCGTGTGACTCCAAAACCTGATAAGGTAGATGTCTTTGTGACCAAGTCAAAGATT
GACCAAAATCTAGATTTTGAAGACTTATCGGATTTGCCAGATATGGAAGAATTGGCTCAAATGTCTCCAGATGAATTTAT
CAAAACCCTGGAAAAAAGCATCGCAGACAAAACCAAGGATGATATCGAAGCCATTCAATCTCTTGAGCAAGTTGAAGCCA
AGGAAGAAGAGCAAGAGCAGGCTGAACAAGAAGCTGAGAGTAAGAAAGAACCTTACATCTACTACATCCTTTCTTTTGCT
AAGTTGGCTGACTTGGTAGCTTTTGCCAAGACAGTGACTTTTGAAATGGAAACTTCTGAACTCTACAAAATGAACGAGCG
CTATTATTTGACCATTTTAGTGGATATTGAAAATCATCCAAGCCCATATCCAGCTTGGCTGTTGGCCCGTATGCGCGAGT
TTGCAGACGATAGTGATATCAGTCGCTCAGTCTTACAAGAGTATGGTCAAGTCTTGATGAGTCACGATGCAGTGCTCAAT
CTGCAAAAAATCGGCTAA

Domains

Predicted by InterproScan.

Negative regulator of genetic competence (MecA) (MecA)

(1-239)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A064C3U8

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  mecA Streptococcus pneumoniae Rx1

99.592

100

0.996
  mecA Streptococcus pneumoniae D39

99.592

100

0.996
  mecA Streptococcus pneumoniae R6

99.592

100

0.996
  mecA Streptococcus pneumoniae TIGR4

99.184

100

0.992
  mecA Streptococcus thermophilus LMD-9

47.791

100

0.486
  mecA Streptococcus thermophilus LMG 18311

47.39

100

0.482
  mecA Streptococcus mutans UA159

48.163

100

0.482