Detailed information    

insolico Bioinformatically predicted

Overview

Name   comE/blpR   Type   Regulator
Locus tag   U0448_RS07715 Genome accession   NZ_CP139860
Coordinates   1505593..1506330 (+) Length   245 a.a.
NCBI ID   WP_001219137.1    Uniprot ID   -
Organism   Streptococcus pneumoniae strain 21011     
Function   activate transcription of early competence genes; regulation of comX expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 1500593..1511330
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  U0448_RS07680 - 1501524..1501763 (-) 240 WP_001813906.1 hypothetical protein -
  U0448_RS07685 - 1501925..1502212 (-) 288 WP_000777760.1 hypothetical protein -
  U0448_RS07690 - 1502222..1502632 (-) 411 WP_001278301.1 HIT family protein -
  U0448_RS07695 pptA 1502700..1503431 (+) 732 WP_000889923.1 ABC transporter ATP-binding protein Regulator
  U0448_RS07700 - 1503428..1504477 (+) 1050 WP_000653752.1 ABC transporter permease -
  U0448_RS07705 - 1504645..1504974 (-) 330 WP_000132572.1 hypothetical protein -
  U0448_RS07710 - 1505250..1505588 (+) 339 WP_000682121.1 LytTR family DNA-binding domain-containing protein -
  U0448_RS07715 comE/blpR 1505593..1506330 (+) 738 WP_001219137.1 LytTR family DNA-binding domain-containing protein Regulator
  U0448_RS07720 - 1506344..1507684 (+) 1341 WP_050258907.1 sensor histidine kinase -
  U0448_RS07725 blpC 1507712..1507885 (-) 174 WP_050258908.1 quorum-sensing system pheromone BlpC -
  U0448_RS07730 - 1507942..1509303 (-) 1362 WP_042516064.1 bacteriocin secretion accessory protein -
  U0448_RS07735 comA/nlmT 1509314..1509961 (-) 648 WP_078102557.1 ATP-binding cassette domain-containing protein Regulator
  U0448_RS07740 comA/nlmT 1509977..1510990 (-) 1014 WP_307772067.1 ABC transporter transmembrane domain-containing protein Regulator

Sequence

Protein


Download         Length: 245 a.a.        Molecular weight: 28768.92 Da        Isoelectric Point: 6.2366

>NTDB_id=911363 U0448_RS07715 WP_001219137.1 1505593..1506330(+) (comE/blpR) [Streptococcus pneumoniae strain 21011]
MRIFVLEDDFSQQTRIETTIEKLLKEHHITLSSFEVFGKPDQLLAEVHEKGAHQLFFLDIEIRNEEMKGLEVARKIRDRD
PYALIVFVTTHSEFMPLSFRYQVSALDYIDKALSAEEFESRIETALLYANGQDSKSLAEDCFYFKSKFAQFQYPFKEVYY
LETSTRPHRVILYTKTDRLEFTASLEEVLKQEPRLLQCHRSFLINPANVVHLDKKEKLLFFPNGGSCLIARYKVREVSEA
INNLH

Nucleotide


Download         Length: 738 bp        

>NTDB_id=911363 U0448_RS07715 WP_001219137.1 1505593..1506330(+) (comE/blpR) [Streptococcus pneumoniae strain 21011]
ATGAGAATATTTGTTTTAGAAGATGATTTTTCCCAACAGACTAGAATTGAAACGACGATTGAGAAACTCTTGAAGGAACA
TCATATCACTCTGAGTTCTTTTGAAGTTTTTGGTAAGCCAGATCAATTGCTGGCAGAGGTGCATGAGAAGGGGGCCCATC
AGCTATTCTTTTTGGATATTGAGATTCGAAATGAGGAGATGAAGGGTCTGGAAGTGGCTAGAAAGATTCGGGATCGGGAT
CCGTATGCCCTGATTGTCTTTGTGACGACTCACTCGGAGTTTATGCCCCTGTCCTTTCGCTACCAAGTGTCTGCTCTGGA
CTATATTGATAAGGCCCTTTCGGCAGAGGAGTTTGAATCTCGTATCGAGACAGCCCTCCTCTATGCCAATGGTCAAGACA
GTAAAAGTCTAGCGGAAGATTGCTTTTACTTTAAATCAAAATTTGCTCAATTCCAGTATCCTTTTAAAGAGGTTTACTAT
CTCGAAACGTCCACAAGACCCCATCGTGTTATTCTCTATACCAAGACAGACAGGCTGGAATTTACAGCGAGTCTAGAGGA
GGTTCTCAAGCAGGAGCCTCGTCTCTTGCAGTGCCATCGCTCTTTTCTCATCAATCCTGCCAATGTGGTGCATTTAGATA
AGAAAGAAAAACTGCTTTTCTTTCCCAATGGTGGAAGTTGTCTAATCGCGCGTTATAAGGTCAGGGAAGTGTCTGAGGCT
ATTAATAACTTACACTGA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(3-122)

LytTr DNA-binding domain (LytTR)

(151-241)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comE/blpR Streptococcus mutans UA159

53.441

100

0.539
  comE/comE1 Streptococcus equinus JB1

43.038

96.735

0.416
  comE/comE2 Streptococcus equinus JB1

38.43

98.776

0.38