Detailed information    

insolico Bioinformatically predicted

Overview

Name   mecA   Type   Regulator
Locus tag   SM123_RS08755 Genome accession   NZ_CP139419
Coordinates   1810394..1811131 (-) Length   245 a.a.
NCBI ID   WP_003004768.1    Uniprot ID   I1ZKF6
Organism   Streptococcus lingualis strain S5     
Function   degradation of ComW (predicted from homology)   
Competence regulation

Genomic Context

Location: 1805394..1816131
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  SM123_RS08735 (SM123_08735) - 1805770..1806996 (-) 1227 WP_023919307.1 cysteine desulfurase -
  SM123_RS08740 (SM123_08740) sufD 1807006..1808268 (-) 1263 WP_070590541.1 Fe-S cluster assembly protein SufD -
  SM123_RS08745 (SM123_08745) sufC 1808335..1809105 (-) 771 WP_003004238.1 Fe-S cluster assembly ATPase SufC -
  SM123_RS08750 (SM123_08750) - 1809240..1810397 (-) 1158 WP_320909443.1 MraY family glycosyltransferase -
  SM123_RS08755 (SM123_08755) mecA 1810394..1811131 (-) 738 WP_003004768.1 adaptor protein MecA Regulator
  SM123_RS08760 (SM123_08760) - 1811267..1812103 (-) 837 WP_003010265.1 undecaprenyl-diphosphate phosphatase -
  SM123_RS08765 (SM123_08765) - 1812212..1814119 (-) 1908 WP_320909444.1 DUF2207 domain-containing protein -
  SM123_RS08770 (SM123_08770) - 1814237..1815799 (+) 1563 WP_320909445.1 ABC transporter substrate-binding protein/permease -

Sequence

Protein


Download         Length: 245 a.a.        Molecular weight: 28238.84 Da        Isoelectric Point: 4.0867

>NTDB_id=909559 SM123_RS08755 WP_003004768.1 1810394..1811131(-) (mecA) [Streptococcus lingualis strain S5]
MKMKQISDSTIKITIQLEDLEERGMEIADFLVPQEKTEEFFYAILDELEMPESFLDSGMLSFRVTPKPDKLDVFVTKSKI
DQQLDFEDLSDLPDMEELSRMTPDEFIKTLEKTISDKTKGDAEAIHHLEQEELRDNQEQDPTSEAPVSQYIYYILRFSNI
QQAVAFSKTVSFPVDTSELYKMGSDYYLTVLIDTEDQPNQYPTWLLAIIREYADDSEVTRAVLQEHGHLLMVSGAIENLK
KVASL

Nucleotide


Download         Length: 738 bp        

>NTDB_id=909559 SM123_RS08755 WP_003004768.1 1810394..1811131(-) (mecA) [Streptococcus lingualis strain S5]
ATGAAGATGAAGCAAATTAGTGATTCAACTATTAAGATCACGATCCAACTAGAAGACTTAGAAGAACGTGGGATGGAAAT
TGCTGATTTCCTTGTCCCGCAAGAAAAAACAGAAGAATTTTTCTATGCCATTTTGGATGAACTCGAAATGCCAGAAAGCT
TCCTGGATAGCGGGATGCTGAGTTTTCGCGTGACACCAAAACCAGATAAATTGGATGTTTTTGTTACCAAATCAAAAATT
GATCAACAATTGGATTTTGAGGATTTGTCAGATCTTCCTGATATGGAAGAATTGTCGCGCATGACGCCAGATGAATTTAT
CAAAACCTTGGAAAAAACGATCTCTGATAAGACAAAAGGGGATGCAGAAGCTATTCACCATTTGGAACAAGAAGAGTTAC
GGGACAATCAAGAACAAGATCCTACATCTGAAGCACCAGTAAGTCAGTATATTTATTACATTTTGCGTTTTTCAAATATC
CAGCAAGCAGTTGCCTTTTCAAAAACGGTCAGCTTTCCAGTGGATACCTCTGAATTATACAAAATGGGATCCGATTATTA
TTTAACTGTCTTGATCGATACAGAGGATCAACCAAATCAATATCCAACCTGGTTACTTGCCATCATTCGGGAGTATGCGG
ATGATTCAGAAGTGACACGGGCCGTTCTGCAGGAACATGGTCATTTATTAATGGTGTCTGGTGCGATTGAGAATTTGAAG
AAAGTTGCTAGCTTATGA

Domains

Predicted by InterproScan.

Negative regulator of genetic competence (MecA) (MecA)

(1-239)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB I1ZKF6

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  mecA Streptococcus pneumoniae Rx1

68.571

100

0.686
  mecA Streptococcus pneumoniae D39

68.571

100

0.686
  mecA Streptococcus pneumoniae R6

68.571

100

0.686
  mecA Streptococcus pneumoniae TIGR4

68.571

100

0.686
  mecA Streptococcus mutans UA159

49.798

100

0.502
  mecA Streptococcus thermophilus LMD-9

47.561

100

0.478
  mecA Streptococcus thermophilus LMG 18311

47.154

100

0.473