Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   R5U37_RS01415 Genome accession   NZ_CP137476
Coordinates   227675..228958 (-) Length   427 a.a.
NCBI ID   WP_002324312.1    Uniprot ID   A0AB37VT26
Organism   Enterococcus faecium strain HMC8C-1     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 222675..233958
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  R5U37_RS01385 (R5U37_01395) - 222834..223790 (-) 957 WP_002317103.1 glycosyltransferase family 2 protein -
  R5U37_RS01390 (R5U37_01400) - 223962..224315 (-) 354 WP_002317104.1 PepSY domain-containing protein -
  R5U37_RS01395 (R5U37_01405) pepA 224514..225593 (+) 1080 WP_137206318.1 glutamyl aminopeptidase -
  R5U37_RS01400 (R5U37_01410) - 225885..226205 (+) 321 WP_002317106.1 thioredoxin family protein -
  R5U37_RS01405 (R5U37_01415) - 226235..226702 (+) 468 WP_002317107.1 universal stress protein -
  R5U37_RS01410 (R5U37_01420) ytpR 227012..227617 (+) 606 WP_137206316.1 YtpR family tRNA-binding protein -
  R5U37_RS01415 (R5U37_01425) htrA 227675..228958 (-) 1284 WP_002324312.1 S1C family serine protease Regulator
  R5U37_RS01420 (R5U37_01430) rlmH 229411..229890 (+) 480 WP_137206313.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  R5U37_RS01425 (R5U37_01435) - 230285..230761 (+) 477 WP_002301832.1 PTS sugar transporter subunit IIB -
  R5U37_RS01430 (R5U37_01440) - 230776..231576 (+) 801 WP_002301831.1 PTS sugar transporter subunit IIC -
  R5U37_RS01435 (R5U37_01445) - 231569..232378 (+) 810 WP_002301830.1 PTS system mannose/fructose/sorbose family transporter subunit IID -
  R5U37_RS01440 (R5U37_01450) - 232391..232810 (+) 420 WP_002301829.1 PTS sugar transporter subunit IIA -

Sequence

Protein


Download         Length: 427 a.a.        Molecular weight: 44453.55 Da        Isoelectric Point: 4.7976

>NTDB_id=898184 R5U37_RS01415 WP_002324312.1 227675..228958(-) (htrA) [Enterococcus faecium strain HMC8C-1]
MERKDVTPKMKKNNGIWRKLGLGLVGGIIGGLVTAGIFYAVMGSGNAASNSGGHQNSAGETVVENVKVNVDSDITNAVDK
VQDAVVSVINLQSQNQGTNGFGQLFGQQQESSDDSNLEASSEGSGVIYKKSGNSAYIVTNNHVVEGQQGLEVLLKDGTKV
KAELVGTDAYSDLAVLKISADKVNKVASFGDSNSLKVGEPAIAIGSPLGSEYANSVTSGIISSLNRQVTSTNESNQTVNI
NAIQTDAAINPGNSGGPLVNIEGQVIGINSSKIASTSASSSGVSVEGMGFAIPSNDVVNIINQLEKDGKVTRPALGITMV
DLSAVSTQQQEQILKIPESVTNGVIVTSVQPATPAEKAGLKQYDVITKIDDTDVSSGVELQSVLYQKKVGDSVKVTYYRG
KEKKTTTIQLTIDQSALKQSQSENSGN

Nucleotide


Download         Length: 1284 bp        

>NTDB_id=898184 R5U37_RS01415 WP_002324312.1 227675..228958(-) (htrA) [Enterococcus faecium strain HMC8C-1]
ATGGAGAGAAAAGATGTGACACCAAAAATGAAAAAGAATAATGGAATCTGGCGTAAGCTGGGTCTAGGCTTAGTCGGTGG
AATTATTGGGGGCTTGGTAACGGCTGGTATTTTTTATGCTGTCATGGGTTCTGGAAACGCAGCGTCAAATTCGGGTGGTC
ATCAAAATTCAGCGGGCGAAACTGTCGTTGAGAATGTCAAAGTCAATGTCGATTCAGATATCACGAATGCGGTCGATAAA
GTCCAAGATGCGGTGGTATCTGTTATCAATCTTCAAAGCCAAAATCAAGGGACCAACGGCTTTGGTCAACTATTTGGCCA
ACAACAAGAAAGTTCTGATGATAGCAATCTAGAGGCTTCTAGTGAAGGTAGTGGTGTCATCTACAAAAAAAGTGGTAATT
CCGCTTATATCGTAACGAATAATCACGTAGTGGAAGGCCAACAAGGATTAGAAGTTTTATTAAAAGATGGAACAAAAGTC
AAAGCTGAATTAGTCGGGACGGATGCTTATTCTGACTTAGCCGTTTTGAAAATCAGTGCAGATAAAGTGAACAAAGTTGC
TTCATTTGGTGACTCTAATTCATTGAAAGTAGGTGAACCTGCGATCGCAATTGGTTCTCCTCTAGGTTCTGAATATGCCA
ACTCTGTGACTTCGGGGATCATCTCTTCATTGAATCGCCAAGTAACCAGCACGAACGAGTCAAATCAAACGGTCAATATC
AATGCGATCCAAACAGATGCTGCGATTAACCCTGGTAATTCTGGTGGTCCATTAGTTAATATTGAAGGACAAGTGATCGG
GATCAATTCAAGTAAAATTGCAAGTACTTCTGCTTCTTCATCAGGTGTAAGCGTGGAAGGAATGGGCTTTGCGATCCCAA
GTAACGATGTAGTAAATATTATCAACCAACTTGAAAAAGATGGAAAAGTAACCCGTCCTGCTCTAGGGATCACAATGGTT
GACCTTTCAGCCGTTTCAACCCAACAACAAGAACAAATCTTGAAAATTCCTGAGTCTGTGACAAATGGTGTGATTGTTAC
TAGCGTTCAACCGGCGACACCTGCAGAAAAAGCTGGCTTGAAACAATATGATGTCATTACAAAAATCGATGATACTGATG
TTTCTTCTGGTGTAGAATTACAATCTGTCTTATATCAGAAAAAAGTCGGCGATTCAGTGAAGGTCACTTACTATCGCGGA
AAAGAAAAGAAAACAACAACGATTCAATTAACAATTGATCAATCCGCATTAAAACAAAGTCAATCAGAGAACTCTGGTAA
CTAA

Domains

Predicted by InterproScan.

Trypsin-like peptidase domain (Trypsin_2)

(123-268)

PDZ domain (PDZ_2)

(313-410)

Peptidase family M50 (Peptidase_M50)

(12-414)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus gordonii str. Challis substr. CH1

53.483

94.145

0.504
  htrA Streptococcus mutans UA159

54.177

92.506

0.501
  htrA Streptococcus pneumoniae D39

58.631

78.689

0.461
  htrA Streptococcus pneumoniae TIGR4

58.631

78.689

0.461
  htrA Streptococcus pneumoniae R6

58.631

78.689

0.461
  htrA Streptococcus pneumoniae Rx1

58.631

78.689

0.461
  htrA Streptococcus mitis NCTC 12261

57.738

78.689

0.454