Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   R5U34_RS01300 Genome accession   NZ_CP137465
Coordinates   262224..263510 (-) Length   428 a.a.
NCBI ID   WP_002325236.1    Uniprot ID   A0A366TVN3
Organism   Enterococcus faecium strain AD21B     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 257224..268510
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  R5U34_RS01270 (R5U34_01270) - 257501..258448 (-) 948 WP_002289860.1 glycosyltransferase family 2 protein -
  R5U34_RS01275 (R5U34_01275) - 258671..259021 (-) 351 WP_002289862.1 PepSY domain-containing protein -
  R5U34_RS01280 (R5U34_01280) pepA 259221..260300 (+) 1080 WP_002351291.1 glutamyl aminopeptidase -
  R5U34_RS01285 (R5U34_01285) - 260443..260763 (+) 321 WP_002287837.1 thioredoxin family protein -
  R5U34_RS01290 (R5U34_01290) - 260785..261249 (+) 465 WP_002287838.1 universal stress protein -
  R5U34_RS01295 (R5U34_01295) ytpR 261454..262059 (+) 606 WP_104775287.1 YtpR family tRNA-binding protein -
  R5U34_RS01300 (R5U34_01300) htrA 262224..263510 (-) 1287 WP_002325236.1 S1C family serine protease Regulator
  R5U34_RS01305 (R5U34_01305) rlmH 263939..264418 (+) 480 WP_002287841.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  R5U34_RS01310 (R5U34_01310) - 264741..266381 (+) 1641 WP_002351320.1 membrane protein -
  R5U34_RS01315 (R5U34_01315) - 266553..267512 (+) 960 WP_002303791.1 IS30-like element IS6770 family transposase -
  R5U34_RS01320 (R5U34_01320) - 267523..267594 (-) 72 Protein_261 TetR/AcrR family transcriptional regulator -
  R5U34_RS01325 (R5U34_01325) - 267736..268350 (+) 615 WP_002324335.1 GNAT family N-acetyltransferase -

Sequence

Protein


Download         Length: 428 a.a.        Molecular weight: 44827.81 Da        Isoelectric Point: 4.5419

>NTDB_id=898075 R5U34_RS01300 WP_002325236.1 262224..263510(-) (htrA) [Enterococcus faecium strain AD21B]
MDRKNVTPKMKKNKNNSLWRKLGLGLVGGIVGGLLTAGIFYAAMGTGNNSSTTSGNQNSAGETVVENVKVNVDSDITKAV
DKVQDAVVSVINLQSQNQSSGFGGLFGQQEESSSSDDSNLEAYSEGSGVIYKKDGNTAYVVTNNHVVDGQQGLEVLMKDG
TKVKAELVGTDAYSDLAVLKINSDKVETVASFGDSSALKVGEPAIAIGSPLGSEYANSVTSGIISSLNRQVTSTNESNET
VNINAIQTDAAINPGNSGGPLVNIEGQVIGINSSKIASTSESTSNVSVEGMGFAIPSNDVVNIINQLEKDGKVTRPALGI
TMVDLSAVSTQQQEQILKIPSSVTNGVIVTNVQTATPAEKAGLKQYDVITKIDDKEVSSGVELQSALYKKKVGDSVKITY
YEGSKEKTTTVELTIDQSALKQNQNSEN

Nucleotide


Download         Length: 1287 bp        

>NTDB_id=898075 R5U34_RS01300 WP_002325236.1 262224..263510(-) (htrA) [Enterococcus faecium strain AD21B]
ATGGATAGAAAAAATGTGACACCAAAGATGAAAAAAAATAAAAATAATAGCCTCTGGCGTAAGTTAGGTCTAGGGCTTGT
TGGAGGGATCGTTGGAGGATTACTGACAGCTGGTATTTTTTATGCAGCGATGGGCACTGGCAACAATAGTTCTACTACAA
GTGGCAATCAAAATTCTGCTGGTGAAACAGTTGTGGAAAACGTCAAAGTCAATGTAGATTCTGATATCACCAAAGCAGTA
GATAAAGTTCAAGACGCTGTCGTTTCTGTTATCAACTTGCAAAGTCAAAACCAATCAAGCGGTTTTGGCGGACTATTCGG
GCAGCAAGAAGAAAGTAGCAGCTCAGATGATAGTAATTTGGAAGCTTATAGTGAAGGAAGCGGCGTGATCTACAAAAAAG
ACGGGAATACTGCTTATGTAGTCACAAACAACCACGTAGTAGATGGCCAGCAAGGTCTTGAAGTCTTGATGAAAGACGGT
ACGAAGGTAAAAGCTGAATTAGTTGGAACAGATGCTTATTCAGATTTAGCGGTGTTGAAGATCAATTCAGACAAAGTCGA
AACAGTTGCCTCTTTTGGTGACTCAAGTGCTCTGAAGGTTGGTGAGCCTGCGATTGCGATTGGTTCCCCATTAGGATCTG
AATATGCGAATTCTGTCACTTCAGGAATCATTTCTTCCTTGAACCGACAAGTAACAAGTACAAATGAATCGAACGAAACA
GTCAATATCAATGCGATCCAAACAGATGCAGCAATCAACCCTGGAAATTCTGGTGGTCCTTTAGTGAATATCGAAGGACA
AGTTATCGGTATCAACTCAAGTAAGATCGCAAGTACTTCTGAATCTACTTCTAATGTAAGCGTAGAAGGAATGGGATTTG
CTATTCCAAGTAACGATGTAGTGAATATCATCAATCAACTGGAAAAAGACGGAAAAGTGACACGTCCAGCTCTAGGTATC
ACAATGGTCGACTTATCTGCCGTTTCTACTCAGCAACAAGAACAAATCTTGAAGATTCCTTCATCTGTAACTAACGGTGT
CATCGTGACAAATGTCCAAACAGCTACACCGGCTGAAAAAGCTGGATTGAAACAATACGACGTCATTACTAAGATCGATG
ACAAAGAAGTTTCTTCTGGTGTAGAACTTCAATCTGCTTTGTATAAGAAAAAAGTGGGAGATTCTGTCAAAATCACTTAC
TATGAAGGCTCGAAAGAAAAAACAACTACTGTTGAATTGACGATCGATCAATCGGCATTAAAACAAAATCAAAATAGTGA
AAATTAA

Domains

Predicted by InterproScan.

PDZ domain (PDZ_2)

(316-413)

Trypsin-like peptidase domain (Trypsin_2)

(126-271)

Peptidase family M50 (Peptidase_M50)

(10-416)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A366TVN3

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus gordonii str. Challis substr. CH1

54.707

91.822

0.502
  htrA Streptococcus mutans UA159

59.887

82.71

0.495
  htrA Streptococcus mitis NCTC 12261

52.645

92.757

0.488
  htrA Streptococcus pneumoniae TIGR4

59.05

78.738

0.465
  htrA Streptococcus pneumoniae D39

59.05

78.738

0.465
  htrA Streptococcus pneumoniae Rx1

59.05

78.738

0.465
  htrA Streptococcus pneumoniae R6

59.05

78.738

0.465