Detailed information    

insolico Bioinformatically predicted

Overview

Name   comA   Type   Regulator
Locus tag   R4701_RS04980 Genome accession   NZ_CP137114
Coordinates   990514..992667 (-) Length   717 a.a.
NCBI ID   WP_317806024.1    Uniprot ID   -
Organism   Streptococcus pneumoniae strain 15P3054     
Function   processing and transport of ComC (predicted from homology)   
Competence regulation

Genomic Context

Location: 985514..997667
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  R4701_RS04965 - 988130..988273 (-) 144 WP_050167432.1 hypothetical protein -
  R4701_RS04970 purC 988275..988982 (-) 708 WP_000043304.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
  R4701_RS04975 comB 989152..990501 (-) 1350 WP_317806023.1 competence pheromone export protein ComB Regulator
  R4701_RS04980 comA 990514..992667 (-) 2154 WP_317806024.1 peptide cleavage/export ABC transporter ComA Regulator
  R4701_RS04985 - 993047..993538 (-) 492 WP_000671990.1 hypothetical protein -
  R4701_RS04990 - 993519..994115 (-) 597 WP_000687787.1 ATP-binding cassette domain-containing protein -
  R4701_RS04995 - 994112..994594 (-) 483 WP_001232094.1 stage II sporulation protein M -
  R4701_RS05000 - 994591..995727 (-) 1137 WP_000698828.1 hypothetical protein -
  R4701_RS05005 - 995734..996030 (-) 297 WP_000837726.1 uberolysin/carnocyclin family circular bacteriocin -
  R4701_RS05010 - 996574..997467 (-) 894 WP_000343891.1 XRE family transcriptional regulator -

Sequence

Protein


Download         Length: 717 a.a.        Molecular weight: 80380.49 Da        Isoelectric Point: 6.4574

>NTDB_id=896167 R4701_RS04980 WP_317806024.1 990514..992667(-) (comA) [Streptococcus pneumoniae strain 15P3054]
MKFGKRHYRPQVDQMDCGVASLAMVFGYYGSYYFLAHLRELAKTTMDGTTALGLVKVAEEIGFETRAIKADMTLFDLPDL
TFPFVAHVLKEGKLLHYYVVTGQDKDSIHIADPDPGVKLTKLPRERFEEEWTGVTLFMAPSPDYKPHKEQKNGLLSFIPI
LVKQRGLIANIVLATLLVTVINIVGSYYLQSIIDTYVPDQMRSTLGIISIGLVIVYILQQILSYAQEYLLLVLGQRLSID
VILSYIKHVFHLPMSFFATRRTGEIVSRFTDANSIIDALASTILSIFLDVSTVVIISLVLFSQNTNLFFMTLLALPIYTV
IIFAFMKPFEKMNRDTMEANAVLSSSIIEDINGIETIKSLTSESQRYQKIDKEFVDYLKKSFTYSRAESQQKALKKVAHL
LLNVGILWMGAVLVMDGKMSLGQLITYNTLLVYFTNLLENIINLQTKLQTAQVANNRLNEVYLVASEFEEKKTVEDLSLM
KGEMTFKQVHYKYGYGRDVLSDINLTVPQGSKVAFVGISGSGKTTLAKMMVNFYDPSQGEISLGGVNLNQIDKKALRQYI
NYLPQQPYVFNGTILENLLLGAKEGTTQEDILRAVELAEIREDIERMPLNYQTELTSDGAGISGGQRQRIALARALLTDA
PVLILDEATSSLDILTEKRIVDNLIALDKTLIFIAHRLTIAERTEKVVVLDKGKIVEEGKHADLLAQGGFYAHLVNS

Nucleotide


Download         Length: 2154 bp        

>NTDB_id=896167 R4701_RS04980 WP_317806024.1 990514..992667(-) (comA) [Streptococcus pneumoniae strain 15P3054]
ATGAAATTTGGGAAACGTCACTATCGTCCGCAAGTGGATCAGATGGACTGCGGTGTAGCTTCATTAGCCATGGTTTTTGG
CTACTATGGTAGTTATTATTTTTTGGCTCACTTGCGAGAATTGGCTAAGACGACCATGGATGGGACGACGGCTTTGGGCT
TGGTCAAGGTGGCAGAGGAGATTGGTTTTGAGACGCGAGCCATTAAGGCGGATATGACGCTTTTTGACTTGCCGGATTTG
ACTTTTCCTTTTGTTGCCCATGTGCTTAAGGAAGGGAAATTGCTCCACTACTATGTGGTGACTGGGCAGGATAAGGATAG
CATTCATATTGCCGATCCAGATCCCGGGGTGAAGTTGACTAAACTGCCACGTGAGCGTTTTGAGGAAGAATGGACAGGAG
TGACTCTTTTTATGGCACCTAGTCCAGACTATAAGCCTCATAAGGAACAAAAAAATGGTCTGCTCTCTTTTATCCCTATA
TTAGTGAAGCAGCGTGGCTTGATTGCCAATATCGTTTTGGCAACACTCTTGGTAACCGTGATTAACATTGTGGGTTCTTA
TTATCTGCAGTCTATCATTGATACCTATGTGCCAGATCAGATGCGTTCGACACTAGGGATTATTTCTATTGGGCTAGTCA
TCGTCTACATCCTCCAGCAAATCTTGTCTTACGCTCAGGAGTATCTCTTGCTTGTTTTGGGGCAACGCTTGTCGATTGAC
GTGATTTTGTCCTATATCAAGCATGTTTTTCACCTCCCTATGTCCTTCTTTGCGACACGCAGGACAGGGGAGATCGTGTC
TCGTTTTACAGATGCTAACAGTATCATCGATGCGCTGGCTTCGACCATCCTTTCGATTTTCCTAGATGTGTCAACGGTTG
TCATTATTTCCCTTGTTCTATTTTCACAAAATACCAATCTCTTTTTCATGACTTTATTGGCGCTTCCTATCTACACAGTG
ATTATCTTTGCCTTTATGAAGCCGTTTGAAAAGATGAATCGGGATACCATGGAAGCCAATGCGGTTCTGTCTTCTTCTAT
CATTGAGGACATCAACGGTATTGAGACTATCAAGTCCTTGACCAGTGAAAGTCAGCGTTACCAAAAAATTGACAAGGAAT
TTGTGGATTATCTGAAGAAATCCTTTACCTATAGTCGAGCAGAGAGTCAGCAAAAGGCTCTGAAAAAGGTTGCCCATCTC
TTGCTTAATGTCGGCATTCTCTGGATGGGGGCTGTTCTGGTCATGGATGGCAAGATGAGTTTGGGGCAGTTGATTACCTA
TAATACCTTGCTGGTTTACTTTACCAATCTTTTGGAAAATATCATCAATCTGCAAACCAAGCTTCAGACAGCGCAGGTTG
CCAATAACCGTCTAAATGAAGTGTATCTAGTAGCTTCTGAGTTTGAGGAGAAGAAAACAGTTGAGGATTTGAGCTTGATG
AAGGGAGAGATGACCTTCAAGCAGGTTCATTACAAGTATGGCTATGGTCGAGACGTCTTGTCGGATATCAATTTAACCGT
TCCCCAAGGGTCTAAGGTGGCTTTTGTGGGGATTTCAGGGTCAGGTAAGACGACTTTGGCCAAGATGATGGTTAATTTTT
ACGACCCAAGTCAAGGGGAGATTAGTCTGGGTGGTGTCAATCTCAATCAGATTGATAAAAAAGCCCTGCGCCAGTACATC
AACTATCTGCCTCAACAGCCCTATGTCTTTAACGGAACGATTTTGGAGAATCTTCTTTTGGGAGCCAAGGAGGGGACGAC
ACAGGAAGATATCTTACGGGCGGTCGAATTGGCAGAGATTCGAGAGGATATCGAGCGCATGCCACTGAATTATCAGACAG
AATTGACTTCGGATGGGGCAGGGATTTCAGGTGGTCAACGTCAGAGAATCGCTTTGGCGCGTGCTCTCTTGACAGATGCG
CCGGTCTTGATTTTGGATGAGGCGACTAGCAGTTTGGATATTTTGACAGAGAAGCGGATTGTCGATAATCTCATTGCTTT
GGACAAGACCTTGATTTTCATTGCTCACCGCTTGACTATTGCTGAGCGGACAGAGAAGGTGGTTGTCTTGGATAAGGGCA
AGATTGTCGAAGAAGGAAAGCATGCTGATTTGCTTGCACAGGGAGGCTTTTACGCCCATTTGGTCAATAGCTAG

Domains

Predicted by InterproScan.

ABC transporter transmembrane region (ABC_membrane)

(170-436)

ABC transporter (ABC_tran)

(500-650)

Peptidase C39 family (Peptidase_C39)

(7-142)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comA Streptococcus pneumoniae Rx1

99.582

100

0.996
  comA Streptococcus pneumoniae D39

99.582

100

0.996
  comA Streptococcus pneumoniae R6

99.582

100

0.996
  comA Streptococcus pneumoniae TIGR4

99.163

100

0.992
  comA Streptococcus mitis SK321

98.326

100

0.983
  comA Streptococcus mitis NCTC 12261

98.047

100

0.98
  comA Streptococcus gordonii str. Challis substr. CH1

80.195

100

0.802
  comA/nlmT Streptococcus mutans UA159

64.435

100

0.644