Detailed information    

insolico Bioinformatically predicted

Overview

Name   comA   Type   Regulator
Locus tag   R4700_RS05815 Genome accession   NZ_CP137112
Coordinates   1126391..1128544 (+) Length   717 a.a.
NCBI ID   WP_277770971.1    Uniprot ID   -
Organism   Streptococcus pneumoniae strain 02H2025     
Function   processing and transport of ComC (predicted from homology)   
Competence regulation

Genomic Context

Location: 1121391..1133544
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  R4700_RS05780 - 1121742..1122911 (+) 1170 WP_277770968.1 pyridoxal phosphate-dependent aminotransferase -
  R4700_RS05785 recO 1122908..1123678 (+) 771 WP_000616162.1 DNA repair protein RecO -
  R4700_RS05790 plsX 1123675..1124667 (+) 993 WP_277770969.1 phosphate acyltransferase PlsX -
  R4700_RS05795 - 1124673..1124906 (+) 234 WP_277770970.1 acyl carrier protein -
  R4700_RS05800 - 1124943..1125243 (+) 301 Protein_1095 transposase family protein -
  R4700_RS05805 blpU 1125446..1125676 (+) 231 Protein_1096 bacteriocin-like peptide BlpU -
  R4700_RS05810 - 1125679..1125804 (+) 126 WP_000346297.1 PncF family bacteriocin immunity protein -
  R4700_RS05815 comA 1126391..1128544 (+) 2154 WP_277770971.1 peptide cleavage/export ABC transporter ComA Regulator
  R4700_RS05820 comB 1128557..1129906 (+) 1350 Protein_1099 competence pheromone export protein ComB -
  R4700_RS05825 purC 1130076..1130783 (+) 708 WP_000043300.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
  R4700_RS05830 - 1130794..1130928 (+) 135 WP_000429436.1 hypothetical protein -

Sequence

Protein


Download         Length: 717 a.a.        Molecular weight: 80430.48 Da        Isoelectric Point: 6.3368

>NTDB_id=896047 R4700_RS05815 WP_277770971.1 1126391..1128544(+) (comA) [Streptococcus pneumoniae strain 02H2025]
MKFGKRHYRPQVDQMDCGVASLAMVFGYYGSYYFLAHLRELAKTTMDGTTALGLVKVAEEIGFETRAIKADMTLFDLPDL
TFPFVAHVLKEGKLLHYYVVTGQDKDSIHIADPDPGVKLTKLPRERFEEEWTGVTLFMAPSPDYKPHKEQKNGLLSFIPI
LVKQRGLIANIVLATLLVTVINIVGSYYLQSIIDTYVPDQMRSTLGIISIGLVIVYIFQQILSYAQEYLLLVLGQRLSID
VILSYIKHVFHLPMSFFATRRTGEIVSRFTDANSIIDALASTILSIFLDVSTVVIISLVLFSQNTNLFFMTLLALPIYTV
IIFAFMKPFEKMNRDTMEANAVLSSSIIEDINGIETIKSLTSESQRYQKIDKEFVDYLKKSFTYSRAESQQKALKKVAHL
LLNVGILWMGAVLVMDGKMSLGQLITYNTLLVYFTNPLENIINLQTKLQTAQVANNRLNEVYLVASEFEEKKTVEDLSLM
KGDMTFKQVHYKYGYGRDVLSDINLTVPQGSKVAFVGISGSGKTTLAKMMVNFYDPSQGEISLGGVNLNQIDKKALRQYI
NYLPQQPYVFNGTILENLLLGAKEGTTQEDILRAVELAEIREDIERMPLNYQTELTSDGAGISGGQRQRIALARALLTDA
PVLILDEATSSLDILTEKRIVDNLMALDKTLIFIAHRLTIAERTEKVVVLDQGKIVEEGKHADLLVQGGFYAHLVNS

Nucleotide


Download         Length: 2154 bp        

>NTDB_id=896047 R4700_RS05815 WP_277770971.1 1126391..1128544(+) (comA) [Streptococcus pneumoniae strain 02H2025]
ATGAAATTTGGGAAACGTCATTATCGTCCGCAGGTGGATCAGATGGACTGCGGTGTAGCTTCATTAGCCATGGTTTTTGG
CTACTATGGTAGTTATTATTTTTTGGCTCACTTGCGAGAATTGGCTAAGACGACCATGGATGGGACGACGGCTTTGGGCT
TGGTCAAGGTGGCAGAGGAGATTGGTTTTGAGACGCGAGCCATTAAGGCAGATATGACGCTTTTTGACTTGCCGGATTTG
ACTTTTCCTTTTGTTGCCCATGTGCTTAAGGAAGGGAAATTGCTCCACTACTATGTGGTGACTGGGCAGGATAAGGATAG
CATTCATATTGCCGATCCAGATCCCGGGGTGAAGTTGACTAAACTGCCACGTGAGCGTTTTGAGGAAGAATGGACAGGAG
TGACTCTTTTTATGGCACCTAGTCCAGACTATAAGCCTCATAAGGAACAAAAAAATGGTCTGCTCTCTTTTATCCCTATA
TTAGTGAAGCAGCGTGGCTTGATTGCCAATATCGTTTTGGCAACACTCTTGGTAACCGTGATTAACATTGTGGGTTCTTA
TTATCTGCAGTCTATCATTGATACCTATGTGCCAGATCAGATGCGTTCGACACTAGGGATTATTTCTATTGGGCTAGTCA
TCGTCTACATCTTCCAGCAAATCTTGTCTTACGCTCAGGAGTATCTCTTGCTTGTTTTGGGGCAACGCTTGTCGATTGAC
GTGATTTTGTCCTATATCAAGCATGTTTTTCACCTCCCTATGTCCTTCTTTGCGACACGCAGGACAGGGGAGATCGTGTC
TCGTTTTACAGATGCTAACAGTATCATCGATGCGCTGGCTTCGACCATCCTTTCGATTTTCCTAGATGTGTCAACGGTTG
TCATTATTTCCCTTGTTCTATTTTCACAAAATACCAATCTCTTTTTCATGACTTTATTGGCGCTTCCTATCTACACAGTG
ATTATCTTTGCCTTTATGAAGCCGTTTGAAAAGATGAATCGGGATACCATGGAAGCCAATGCGGTTCTGTCTTCTTCTAT
CATTGAGGACATCAACGGTATTGAGACTATCAAGTCCTTGACCAGTGAAAGTCAGCGTTACCAAAAAATTGACAAGGAAT
TTGTGGATTATCTGAAGAAATCCTTTACCTATAGTCGAGCAGAGAGTCAGCAAAAGGCTCTGAAAAAGGTTGCCCATCTC
TTGCTTAATGTCGGCATTCTCTGGATGGGGGCTGTTCTGGTCATGGATGGCAAGATGAGTTTGGGGCAGTTGATTACCTA
TAATACCTTGCTGGTTTACTTTACCAATCCTTTGGAAAATATCATCAATCTGCAAACCAAGCTTCAGACAGCGCAGGTTG
CCAATAACCGTCTAAATGAAGTGTATCTAGTAGCTTCTGAGTTTGAGGAGAAGAAAACAGTTGAGGATTTGAGCTTGATG
AAGGGAGATATGACCTTCAAGCAGGTTCATTACAAGTATGGCTATGGTCGAGACGTCTTGTCGGATATCAATTTAACCGT
TCCCCAAGGGTCTAAGGTGGCTTTTGTGGGGATTTCAGGGTCAGGTAAGACGACTTTGGCCAAGATGATGGTTAATTTTT
ACGACCCAAGTCAAGGGGAGATTAGTCTGGGTGGTGTCAATCTCAATCAGATTGATAAAAAAGCCCTGCGCCAGTACATC
AACTATCTGCCTCAACAGCCCTATGTCTTTAACGGAACGATTTTGGAGAATCTTCTTTTGGGAGCCAAGGAGGGGACGAC
ACAGGAAGATATCTTACGGGCGGTCGAATTGGCAGAGATTCGAGAGGATATCGAGCGCATGCCACTGAATTACCAGACAG
AATTGACTTCGGATGGGGCAGGGATTTCAGGTGGTCAACGTCAGAGAATCGCTTTGGCGCGTGCTCTCTTGACAGATGCG
CCGGTCTTGATTTTGGATGAGGCGACTAGCAGTTTGGATATTTTGACAGAGAAGCGGATTGTCGATAATCTCATGGCTTT
GGACAAGACCTTGATTTTCATTGCTCACCGCTTGACTATTGCTGAGCGGACAGAGAAGGTAGTTGTCTTGGATCAGGGCA
AGATTGTCGAAGAAGGAAAGCATGCTGATTTGCTTGTACAGGGTGGCTTTTACGCCCATTTGGTCAATAGCTAG

Domains

Predicted by InterproScan.

Peptidase C39 family (Peptidase_C39)

(7-142)

ABC transporter transmembrane region (ABC_membrane)

(170-438)

ABC transporter (ABC_tran)

(500-650)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comA Streptococcus pneumoniae Rx1

99.582

100

0.996
  comA Streptococcus pneumoniae D39

99.582

100

0.996
  comA Streptococcus pneumoniae R6

99.582

100

0.996
  comA Streptococcus pneumoniae TIGR4

99.442

100

0.994
  comA Streptococcus mitis SK321

98.326

100

0.983
  comA Streptococcus mitis NCTC 12261

98.326

100

0.983
  comA Streptococcus gordonii str. Challis substr. CH1

80.614

100

0.806
  comA/nlmT Streptococcus mutans UA159

64.714

100

0.647