Detailed information    

insolico Bioinformatically predicted

Overview

Name   micA   Type   Regulator
Locus tag   R4711_RS10570 Genome accession   NZ_CP137107
Coordinates   2061412..2062116 (+) Length   234 a.a.
NCBI ID   WP_000722076.1    Uniprot ID   Q9S1K0
Organism   Streptococcus pneumoniae strain 15H4024     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 2056412..2067116
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  R4711_RS10550 coaC 2056702..2057253 (-) 552 WP_001284128.1 phosphopantothenoylcysteine decarboxylase -
  R4711_RS10555 coaB 2057265..2057954 (-) 690 WP_000699498.1 phosphopantothenate--cysteine ligase -
  R4711_RS10560 - 2058184..2059854 (+) 1671 WP_000845281.1 formate--tetrahydrofolate ligase -
  R4711_RS10565 mutY 2060182..2061357 (+) 1176 WP_000886145.1 A/G-specific adenine glycosylase -
  R4711_RS10570 micA 2061412..2062116 (+) 705 WP_000722076.1 response regulator YycF Regulator
  R4711_RS10575 micB 2062109..2063458 (+) 1350 WP_000886210.1 cell wall metabolism sensor histidine kinase VicK Regulator
  R4711_RS10580 vicX 2063460..2064269 (+) 810 WP_001289493.1 MBL fold metallo-hydrolase Regulator
  R4711_RS10585 relB 2064360..2064602 (+) 243 WP_001841708.1 type II toxin-antitoxin system RelB family antitoxin -
  R4711_RS10590 - 2064604..2064858 (+) 255 WP_001809704.1 type II toxin-antitoxin system RelE/ParE family toxin -
  R4711_RS10595 - 2064905..2065557 (+) 653 Protein_2047 potassium channel family protein -
  R4711_RS10600 - 2065817..2066803 (-) 987 WP_000204727.1 L-lactate dehydrogenase -

Sequence

Protein


Download         Length: 234 a.a.        Molecular weight: 26815.63 Da        Isoelectric Point: 4.7164

>NTDB_id=895679 R4711_RS10570 WP_000722076.1 2061412..2062116(+) (micA) [Streptococcus pneumoniae strain 15H4024]
MKKILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKTSSVPILMLSA
KDSEFDKVIGLELGADDYVTKPFSNRELQARVKALLRRSQPMPVDGQEADSKPQPIQIGDLEIVPDAYVAKKYGEELDLT
HREFELLYHLASHTGQVITREHLLETVWGYDYFGDVRTVDVTVRRLREKIEDTPSRPEYILTRRGVGYYMRNNA

Nucleotide


Download         Length: 705 bp        

>NTDB_id=895679 R4711_RS10570 WP_000722076.1 2061412..2062116(+) (micA) [Streptococcus pneumoniae strain 15H4024]
ATGAAAAAAATACTAATTGTAGATGATGAGAAACCAATCTCGGATATTATCAAGTTTAATATGACCAAGGAAGGTTACGA
AGTTGTAACTGCTTTTAATGGTCGTGAAGCGCTAGAGCAATTTGAAGCAGAGCAACCAGATATTATTATTCTGGATTTGA
TGCTTCCAGAAATTGATGGTTTAGAAGTTGCTAAGACCATTCGTAAGACAAGCAGTGTGCCCATTCTTATGCTTTCAGCC
AAAGATAGTGAATTTGATAAGGTTATCGGTTTGGAACTTGGGGCAGATGACTATGTAACGAAACCCTTCTCCAATCGTGA
GTTGCAGGCGCGTGTTAAAGCTCTTCTGCGTCGTTCTCAACCTATGCCAGTAGATGGTCAGGAAGCAGATAGTAAACCTC
AACCTATCCAAATTGGGGATTTAGAAATTGTTCCAGACGCCTACGTGGCTAAAAAATATGGCGAAGAACTAGACTTAACC
CATCGTGAATTTGAGCTTTTGTATCATTTAGCATCGCATACAGGTCAAGTCATCACGCGCGAACACTTGCTTGAGACTGT
CTGGGGTTATGACTATTTTGGTGATGTCCGCACAGTTGATGTGACTGTACGACGTCTGCGTGAGAAGATTGAAGATACGC
CCAGCCGACCAGAGTATATCTTGACGCGCCGTGGTGTAGGGTATTACATGAGAAATAATGCTTGA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(4-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(154-229)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  PDB 1NXS
  PDB 2A9O
  PDB 2A9P

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  micA Streptococcus pneumoniae Cp1015

100

100

1
  vicR Streptococcus mutans UA159

78.541

99.573

0.782
  covR Streptococcus salivarius strain HSISS4

44.156

98.718

0.436
  covR Lactococcus lactis subsp. lactis strain DGCC12653

43.478

98.291

0.427
  scnR Streptococcus mutans UA159

38.197

99.573

0.38