Detailed information    

insolico Bioinformatically predicted

Overview

Name   mecA   Type   Regulator
Locus tag   R4711_RS10045 Genome accession   NZ_CP137107
Coordinates   1958613..1959350 (+) Length   245 a.a.
NCBI ID   WP_000782665.1    Uniprot ID   A0A0B7LV94
Organism   Streptococcus pneumoniae strain 15H4024     
Function   degradation of ComW (predicted from homology)   
Competence regulation

Genomic Context

Location: 1953613..1964350
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  R4711_RS10025 - 1953868..1954971 (+) 1104 WP_191239287.1 glycosyltransferase -
  R4711_RS10030 - 1954973..1955959 (+) 987 WP_000446975.1 glycosyltransferase family 2 protein -
  R4711_RS10035 - 1955975..1957408 (+) 1434 WP_050263727.1 O-antigen polysaccharide polymerase Wzy family protein -
  R4711_RS10040 - 1957437..1958471 (+) 1035 WP_000461502.1 hypothetical protein -
  R4711_RS10045 mecA 1958613..1959350 (+) 738 WP_000782665.1 adaptor protein MecA Regulator
  R4711_RS10050 - 1959501..1960787 (+) 1287 WP_000216382.1 homoserine dehydrogenase -
  R4711_RS10055 thrB 1960789..1961658 (+) 870 WP_000692438.1 homoserine kinase -
  R4711_RS10060 - 1961734..1961886 (+) 153 WP_001835993.1 hypothetical protein -
  R4711_RS10065 msrB 1961953..1962891 (+) 939 WP_317806040.1 peptide-methionine (R)-S-oxide reductase MsrB -

Sequence

Protein


Download         Length: 245 a.a.        Molecular weight: 28377.18 Da        Isoelectric Point: 4.0236

>NTDB_id=895677 R4711_RS10045 WP_000782665.1 1958613..1959350(+) (mecA) [Streptococcus pneumoniae strain 15H4024]
MKMKQISDTTLKITISLEDLMDRGMEIADFLVPQEKTEEFFYAILDELEMPDSFLDTGMLSFRVTPKPDKVDVFVTKSKI
DQNLDFEDLSDLPDMEELAQMSPDEFIKTLEKSIADKTKDDIEAIQSLEQVEAKEEEQEQAEQEAESKKEPYIYYILSFA
KLADLVAFAKTVTFEMETSELYKMNERYYLTILVDIENHPSPYPAWLLARMREFAEDSDISRSVLQEYGQVLMSHDAVLN
LQKIG

Nucleotide


Download         Length: 738 bp        

>NTDB_id=895677 R4711_RS10045 WP_000782665.1 1958613..1959350(+) (mecA) [Streptococcus pneumoniae strain 15H4024]
ATGAAAATGAAACAAATTAGTGATACAACTTTAAAAATCACGATATCTTTAGAGGATTTGATGGATCGTGGAATGGAGAT
TGCTGACTTTCTCGTTCCTCAAGAAAAAACAGAAGAGTTCTTTTATGCTATCTTGGATGAGCTAGAGATGCCTGATAGCT
TTCTGGATACAGGCATGTTGAGCTTCCGTGTGACTCCAAAACCTGATAAGGTAGATGTCTTTGTGACCAAGTCAAAGATT
GACCAAAATCTAGATTTTGAAGACTTATCGGATTTGCCAGATATGGAAGAATTGGCTCAAATGTCTCCAGATGAATTTAT
CAAAACCCTGGAAAAAAGCATCGCAGACAAAACCAAGGATGATATCGAAGCCATTCAATCTCTTGAGCAAGTTGAAGCCA
AGGAAGAAGAGCAAGAGCAGGCTGAACAAGAAGCTGAGAGTAAGAAAGAACCTTACATCTACTACATCCTTTCTTTTGCT
AAGTTGGCTGACTTGGTAGCTTTTGCCAAGACAGTGACTTTTGAAATGGAAACTTCTGAACTCTACAAAATGAACGAGCG
CTATTATTTGACCATTTTAGTGGATATTGAAAATCATCCAAGCCCATATCCAGCTTGGCTGTTGGCCCGTATGCGCGAGT
TTGCAGAGGATAGTGATATCAGTCGCTCAGTCTTACAAGAGTATGGTCAAGTCTTGATGAGTCACGATGCAGTGCTCAAT
CTGCAAAAAATCGGCTAA

Domains

Predicted by InterproScan.

Negative regulator of genetic competence (MecA) (MecA)

(1-239)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0B7LV94

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  mecA Streptococcus pneumoniae Rx1

99.592

100

0.996
  mecA Streptococcus pneumoniae D39

99.592

100

0.996
  mecA Streptococcus pneumoniae R6

99.592

100

0.996
  mecA Streptococcus pneumoniae TIGR4

99.184

100

0.992
  mecA Streptococcus thermophilus LMD-9

48.193

100

0.49
  mecA Streptococcus thermophilus LMG 18311

47.791

100

0.486
  mecA Streptococcus mutans UA159

48.571

100

0.486