Detailed information    

insolico Bioinformatically predicted

Overview

Name   comC/comC2   Type   Regulator
Locus tag   R4711_RS05595 Genome accession   NZ_CP137107
Coordinates   1097327..1097452 (+) Length   41 a.a.
NCBI ID   WP_000799686.1    Uniprot ID   P60242
Organism   Streptococcus pneumoniae strain 15H4024     
Function   binding to ComD; induce autophosphorylation of ComD (predicted from homology)   
Competence regulation

Genomic Context

Location: 1092327..1102452
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  R4711_RS05570 dnaA 1092812..1094173 (-) 1362 WP_000660615.1 chromosomal replication initiator protein DnaA -
  R4711_RS05575 spo0J 1094386..1095144 (-) 759 WP_000410380.1 ParB/RepB/Spo0J family partition protein Regulator
  R4711_RS05580 htrA 1095202..1096383 (-) 1182 WP_000681597.1 S1C family serine protease Regulator
  R4711_RS05585 rlmH 1096566..1097045 (+) 480 WP_000695929.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  R4711_RS05595 comC/comC2 1097327..1097452 (+) 126 WP_000799686.1 competence-stimulating peptide ComC Regulator
  R4711_RS05600 comD/comD2 1097473..1098798 (+) 1326 WP_000364846.1 competence system sensor histidine kinase ComD Regulator
  R4711_RS05605 comE 1098795..1099547 (+) 753 WP_000866065.1 competence system response regulator transcription factor ComE Regulator
  R4711_RS05620 - 1099790..1100332 (-) 543 WP_001863823.1 TetR/AcrR family transcriptional regulator -
  R4711_RS05625 - 1100511..1102219 (+) 1709 Protein_1110 YhgE/Pip family protein -

Sequence

Protein


Download         Length: 41 a.a.        Molecular weight: 4907.00 Da        Isoelectric Point: 11.0006

>NTDB_id=895631 R4711_RS05595 WP_000799686.1 1097327..1097452(+) (comC/comC2) [Streptococcus pneumoniae strain 15H4024]
MKNTVKLEQFVALKEKDLQKIKGGEMRISRIILDFLFLRKK

Nucleotide


Download         Length: 126 bp        

>NTDB_id=895631 R4711_RS05595 WP_000799686.1 1097327..1097452(+) (comC/comC2) [Streptococcus pneumoniae strain 15H4024]
ATGAAAAACACAGTTAAATTGGAACAGTTTGTAGCTTTGAAGGAAAAAGACTTACAAAAGATTAAAGGTGGGGAGATGAG
GATTTCAAGAATCATCCTTGATTTTCTTTTCCTACGAAAAAAGTAA

Domains

Predicted by InterproScan.

COMC family (ComC)

(1-29)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  PDB 6CJ8
  PDB 6COO
  PDB 6COP
  PDB 6COQ
  PDB 6COR
  PDB 6COS
  PDB 6COW
  PDB 6OBW
  PDB 6OC2
  PDB 6OC4
  PDB 6OLD
  PDB 6V1N

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comC/comC2 Streptococcus pneumoniae A66

100

100

1
  comC/comC2 Streptococcus pneumoniae TIGR4

100

100

1
  comC/comC1 Streptococcus pneumoniae R6

80.488

100

0.805
  comC/comC1 Streptococcus pneumoniae G54

80.488

100

0.805
  comC/comC1 Streptococcus pneumoniae D39

80.488

100

0.805
  comC/comC1 Streptococcus pneumoniae Rx1

80.488

100

0.805
  comC Streptococcus mitis SK321

75.61

100

0.756
  comC Streptococcus mitis NCTC 12261

57.5

97.561

0.561