Detailed information    

insolico Bioinformatically predicted

Overview

Name   comD/comD2   Type   Regulator
Locus tag   R4711_RS05600 Genome accession   NZ_CP137107
Coordinates   1097473..1098798 (+) Length   441 a.a.
NCBI ID   WP_000364846.1    Uniprot ID   Q9LB22
Organism   Streptococcus pneumoniae strain 15H4024     
Function   phosphorylation of ComE (predicted from homology)   
Competence regulation

Genomic Context

Location: 1092473..1103798
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  R4711_RS05570 dnaA 1092812..1094173 (-) 1362 WP_000660615.1 chromosomal replication initiator protein DnaA -
  R4711_RS05575 spo0J 1094386..1095144 (-) 759 WP_000410380.1 ParB/RepB/Spo0J family partition protein Regulator
  R4711_RS05580 htrA 1095202..1096383 (-) 1182 WP_000681597.1 S1C family serine protease Regulator
  R4711_RS05585 rlmH 1096566..1097045 (+) 480 WP_000695929.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  R4711_RS05595 comC/comC2 1097327..1097452 (+) 126 WP_000799686.1 competence-stimulating peptide ComC Regulator
  R4711_RS05600 comD/comD2 1097473..1098798 (+) 1326 WP_000364846.1 competence system sensor histidine kinase ComD Regulator
  R4711_RS05605 comE 1098795..1099547 (+) 753 WP_000866065.1 competence system response regulator transcription factor ComE Regulator
  R4711_RS05620 - 1099790..1100332 (-) 543 WP_001863823.1 TetR/AcrR family transcriptional regulator -
  R4711_RS05625 - 1100511..1102219 (+) 1709 Protein_1110 YhgE/Pip family protein -

Sequence

Protein


Download         Length: 441 a.a.        Molecular weight: 51423.95 Da        Isoelectric Point: 7.0711

>NTDB_id=895632 R4711_RS05600 WP_000364846.1 1097473..1098798(+) (comD/comD2) [Streptococcus pneumoniae strain 15H4024]
MDLLGFGTVIVHFLIISHSYRLICKGRINRKELYVFGAYTLLTEIVLEFSFYLLYLDKIGIERFLFPLGLYSYFRWMKQY
ERDRGLFLSLLLSLLYESTHNFLSVTFSSITGDNFVLQYHFPFFFVVTVLTYFVTLKIIYYFHLELAYFDEDYLYPFLKK
VFFALLLLHIVSFVSDMVSTIKHLNSFGSILSSIVFISLLLTFFAMNSHKVQMEKEIALKQKKFEQKHLQNYTDEIVGLY
NEIRGFRHDYAGMLVSMQMAIDSGNLQEIDRIYNEVLVKANHKLRSDKYTYFDLNNIEDSALRSLVAQSIVYARNNGVEF
TLEVKDTITKLPIELLDLVRIMSVLLNNAVEGSADSYKKQMEVAVIKMETETVIVIQNSCKMTMTPSGDLFALGFSTKGR
NRGVGLNNVKELLDKYNNIILETEMEGSTFRQIIRFKREFE

Nucleotide


Download         Length: 1326 bp        

>NTDB_id=895632 R4711_RS05600 WP_000364846.1 1097473..1098798(+) (comD/comD2) [Streptococcus pneumoniae strain 15H4024]
ATGGATTTACTTGGATTTGGGACAGTTATTGTTCATTTTTTAATTATTAGTCACAGTTACCGTTTAATTTGTAAAGGTCG
AATAAATAGAAAAGAATTATACGTTTTTGGTGCTTATACATTACTAACTGAAATAGTACTTGAATTTTCCTTTTATCTTC
TATATTTAGATAAAATAGGGATTGAAAGATTTTTATTTCCTTTGGGCTTATATTCCTATTTTCGATGGATGAAACAGTAT
GAGAGGGATAGAGGACTATTCCTAAGTTTACTACTATCTCTTTTATATGAGAGCACTCATAACTTTCTGTCCGTAACTTT
CTCCTCTATAACAGGAGATAATTTTGTTTTACAATATCATTTCCCATTCTTTTTCGTTGTGACGGTGTTAACCTATTTTG
TTACATTAAAAATCATTTACTATTTCCATTTGGAACTAGCCTATTTTGACGAGGACTACCTTTATCCTTTCTTGAAAAAA
GTATTTTTTGCTTTACTATTGCTACATATTGTATCTTTCGTTTCAGATATGGTAAGTACGATTAAACATTTGAATAGTTT
TGGAAGTATTTTGTCATCTATTGTCTTTATCTCTCTCCTTTTGACCTTCTTTGCAATGAATTCTCATAAAGTTCAAATGG
AGAAAGAGATTGCTTTGAAGCAGAAGAAATTTGAACAGAAACATTTACAGAATTACACAGATGAAATTGTTGGTCTGTAT
AATGAAATCCGTGGTTTTCGACATGATTATGCTGGAATGCTTGTCAGCATGCAGATGGCAATTGACAGTGGTAATTTACA
GGAAATTGACAGAATTTACAATGAAGTTTTAGTCAAAGCAAATCATAAATTGCGTTCAGATAAGTACACTTACTTTGATT
TGAACAACATAGAAGACTCAGCTTTACGAAGTTTGGTTGCTCAGTCAATTGTCTATGCTCGAAATAATGGTGTAGAGTTT
ACACTGGAAGTAAAAGATACGATTACCAAGCTTCCAATTGAACTATTGGATTTGGTTCGTATCATGAGCGTTTTATTGAA
TAATGCTGTCGAAGGATCGGCTGATAGCTATAAAAAGCAGATGGAAGTAGCAGTTATTAAGATGGAAACTGAAACAGTTA
TTGTGATTCAGAATTCATGTAAAATGACGATGACTCCTTCAGGAGATCTATTTGCCTTAGGATTCTCCACTAAGGGAAGA
AATCGCGGAGTCGGATTAAATAATGTGAAAGAACTACTAGATAAGTACAACAATATTATTTTAGAAACAGAGATGGAAGG
CAGTACATTTAGACAAATCATTAGATTTAAGAGGGAATTTGAATGA

Domains

Predicted by InterproScan.

GHKL domain (HATPase_c_5)

(334-434)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q9LB22

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comD/comD2 Streptococcus pneumoniae TIGR4

99.546

100

0.995
  comD/comD1 Streptococcus pneumoniae Rx1

97.279

100

0.973
  comD/comD1 Streptococcus pneumoniae D39

97.279

100

0.973
  comD/comD1 Streptococcus pneumoniae R6

97.279

100

0.973
  comD Streptococcus mitis SK321

92.063

100

0.921
  comD Streptococcus mitis NCTC 12261

86.621

100

0.866
  comD/comD1 Streptococcus gordonii str. Challis substr. CH1

49.733

84.807

0.422
  comD/comD2 Streptococcus gordonii strain NCTC7865

49.468

85.261

0.422