Detailed information    

insolico Bioinformatically predicted

Overview

Name   mecA   Type   Regulator
Locus tag   R4699_RS03095 Genome accession   NZ_CP137105
Coordinates   603826..604563 (+) Length   245 a.a.
NCBI ID   WP_000782677.1    Uniprot ID   A0A0U0DTC6
Organism   Streptococcus pneumoniae strain 16H2092     
Function   degradation of ComW (predicted from homology)   
Competence regulation

Genomic Context

Location: 598826..609563
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  R4699_RS03075 - 599023..600126 (+) 1104 WP_000225897.1 glycosyltransferase -
  R4699_RS03080 - 600128..601114 (+) 987 WP_000446975.1 glycosyltransferase family 2 protein -
  R4699_RS03085 - 601130..602563 (+) 1434 WP_000565094.1 O-antigen polysaccharide polymerase Wzy family protein -
  R4699_RS03090 - 602592..603626 (+) 1035 WP_000461498.1 hypothetical protein -
  R4699_RS03095 mecA 603826..604563 (+) 738 WP_000782677.1 adaptor protein MecA Regulator
  R4699_RS03100 - 604714..606000 (+) 1287 WP_000216382.1 homoserine dehydrogenase -
  R4699_RS03105 thrB 606002..606871 (+) 870 WP_000692438.1 homoserine kinase -
  R4699_RS03110 msrB 607121..608059 (+) 939 WP_000818203.1 peptide-methionine (R)-S-oxide reductase MsrB -

Sequence

Protein


Download         Length: 245 a.a.        Molecular weight: 28395.21 Da        Isoelectric Point: 4.0236

>NTDB_id=895472 R4699_RS03095 WP_000782677.1 603826..604563(+) (mecA) [Streptococcus pneumoniae strain 16H2092]
MKMKQISDTTLKITMSLEDLMDRGMEIADFLVPQEKTEEFFYAILDELEMPDSFLDTGMLSFRVTPKPDKVDVFVTKSKI
DQNLDFEDLSDLPDMEELAQMSPDEFIKTLEKSIADKTKDDIEAIQSLEQVEAKEEEQEQAEQEAESKKEPYIYYILSFA
KLADLVAFAKTVTFEMETSELYKMNERYYLTILVDIENHPSPYPAWLLARMREFAEDSDISRSVLQEYGQVLMSHDAVLN
LQKIG

Nucleotide


Download         Length: 738 bp        

>NTDB_id=895472 R4699_RS03095 WP_000782677.1 603826..604563(+) (mecA) [Streptococcus pneumoniae strain 16H2092]
ATGAAAATGAAACAAATTAGTGATACAACTTTAAAAATCACGATGTCTTTAGAGGATTTGATGGATCGTGGAATGGAGAT
TGCTGACTTTCTCGTTCCTCAAGAAAAAACAGAAGAGTTCTTTTATGCTATCTTGGATGAGCTAGAGATGCCTGATAGCT
TTCTGGATACAGGCATGTTGAGCTTCCGTGTGACTCCAAAACCTGATAAGGTAGATGTCTTTGTGACCAAGTCAAAGATT
GACCAAAATCTAGATTTTGAAGACTTATCGGATTTGCCAGATATGGAAGAATTGGCTCAAATGTCTCCAGATGAATTTAT
CAAAACCCTGGAAAAAAGCATCGCAGACAAAACCAAGGATGATATCGAAGCCATTCAATCTCTTGAGCAAGTTGAAGCCA
AGGAAGAAGAGCAAGAGCAGGCTGAACAAGAAGCTGAGAGTAAGAAAGAACCTTACATCTACTACATCCTTTCTTTTGCT
AAGTTGGCTGACTTGGTAGCTTTTGCCAAGACAGTGACTTTTGAAATGGAAACTTCTGAACTCTACAAAATGAACGAGCG
CTATTATTTGACCATTTTAGTGGATATTGAAAATCATCCAAGCCCATATCCAGCTTGGCTGTTGGCCCGTATGCGCGAGT
TTGCAGAGGATAGTGATATCAGTCGCTCAGTCTTACAAGAGTATGGTCAAGTCTTGATGAGTCACGATGCAGTGCTCAAT
CTGCAAAAAATCGGCTAA

Domains

Predicted by InterproScan.

Negative regulator of genetic competence (MecA) (MecA)

(1-239)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A0U0DTC6

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  mecA Streptococcus pneumoniae Rx1

99.184

100

0.992
  mecA Streptococcus pneumoniae D39

99.184

100

0.992
  mecA Streptococcus pneumoniae R6

99.184

100

0.992
  mecA Streptococcus pneumoniae TIGR4

98.776

100

0.988
  mecA Streptococcus thermophilus LMD-9

47.791

100

0.486
  mecA Streptococcus thermophilus LMG 18311

47.39

100

0.482
  mecA Streptococcus mutans UA159

48.163

100

0.482