Detailed information    

insolico Bioinformatically predicted

Overview

Name   comE/blpR   Type   Regulator
Locus tag   R4710_RS08380 Genome accession   NZ_CP137101
Coordinates   1589016..1589753 (+) Length   245 a.a.
NCBI ID   WP_001219139.1    Uniprot ID   Q9F2F6
Organism   Streptococcus pneumoniae strain 16P2012-2     
Function   activate transcription of early competence genes; regulation of comX expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 1584016..1594753
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  R4710_RS08350 - 1585347..1585634 (-) 288 WP_000777760.1 hypothetical protein -
  R4710_RS08355 - 1585644..1586054 (-) 411 WP_050245350.1 HIT family protein -
  R4710_RS08360 pptA 1586122..1586853 (+) 732 WP_000889923.1 ABC transporter ATP-binding protein Regulator
  R4710_RS08365 - 1586850..1587899 (+) 1050 WP_050245349.1 ABC transporter permease -
  R4710_RS08370 - 1588067..1588396 (-) 330 WP_000132583.1 hypothetical protein -
  R4710_RS08375 - 1588673..1589011 (+) 339 WP_000682124.1 LytTR family DNA-binding domain-containing protein -
  R4710_RS08380 comE/blpR 1589016..1589753 (+) 738 WP_001219139.1 response regulator transcription factor Regulator
  R4710_RS08385 - 1589767..1591107 (+) 1341 WP_317804516.1 sensor histidine kinase -
  R4710_RS08390 blpC 1591151..1591306 (-) 156 WP_000358811.1 quorum-sensing system pheromone BlpC -
  R4710_RS08395 - 1591363..1592724 (-) 1362 WP_001069064.1 bacteriocin secretion accessory protein -
  R4710_RS08400 comA/nlmT 1592735..1594411 (-) 1677 WP_306423909.1 peptide cleavage/export ABC transporter Regulator

Sequence

Protein


Download         Length: 245 a.a.        Molecular weight: 28814.94 Da        Isoelectric Point: 6.0454

>NTDB_id=895207 R4710_RS08380 WP_001219139.1 1589016..1589753(+) (comE/blpR) [Streptococcus pneumoniae strain 16P2012-2]
MRIFVLEDDFSQQTRIETTIEKLLKEHHITLSSFEVFGKPDQLLAEVHEKGAHQLFFLDIEIRNEEMKGLEVARKIREQD
PYALIVFVTTHSEFMPLSFRYQVSALDYIDKALSAEEFESRIETALLYANSQDSKSLAEDCFYFKSKFAQFQYPFKEVYY
LETSPRPHRVILYTKTDRLEFTASLEEVFKQEPRLLQCHRSFLINPANVVHLDKKEKLLFFPNGGSCLIARYKVREVSEA
INNLH

Nucleotide


Download         Length: 738 bp        

>NTDB_id=895207 R4710_RS08380 WP_001219139.1 1589016..1589753(+) (comE/blpR) [Streptococcus pneumoniae strain 16P2012-2]
ATGAGAATATTTGTTTTAGAAGATGATTTTTCCCAACAGACTAGAATTGAAACGACGATTGAGAAACTCTTGAAGGAACA
TCATATCACTCTGAGTTCTTTTGAAGTTTTTGGTAAGCCAGATCAATTGCTGGCAGAGGTGCATGAGAAGGGGGCCCATC
AGCTATTCTTTTTGGATATTGAGATTCGAAATGAGGAGATGAAGGGTCTGGAAGTGGCTAGAAAGATTCGGGAACAAGAC
CCTTATGCCCTAATCGTCTTTGTGACGACTCACTCGGAGTTTATGCCTCTGTCCTTTCGCTACCAAGTGTCAGCTTTGGA
CTACATTGATAAGGCCCTTTCGGCAGAGGAGTTTGAATCTCGTATCGAGACAGCCCTCCTCTATGCCAATAGTCAAGATA
GTAAAAGTCTGGCGGAAGATTGCTTTTACTTTAAATCAAAATTTGCCCAATTCCAATATCCTTTCAAAGAGGTTTACTAT
CTCGAAACATCCCCAAGACCCCATCGTGTTATTCTCTATACCAAGACGGACAGGCTAGAATTTACGGCGAGTTTAGAGGA
GGTTTTTAAGCAGGAACCCCGTCTCTTGCAGTGCCATCGCTCTTTTCTTATCAATCCTGCAAATGTGGTGCATTTGGATA
AGAAAGAAAAACTCCTTTTCTTTCCCAATGGTGGAAGCTGTCTGATCGCGCGTTATAAGGTCAGGGAAGTGTCTGAGGCT
ATTAATAACTTACACTGA

Domains

Predicted by InterproScan.

LytTr DNA-binding domain (LytTR)

(151-241)

Response regulator receiver domain (Response_reg)

(3-122)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB Q9F2F6

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comE/blpR Streptococcus mutans UA159

54.321

99.184

0.539
  comE/comE1 Streptococcus equinus JB1

43.882

96.735

0.424
  comE/comE2 Streptococcus equinus JB1

38.843

98.776

0.384