Detailed information    

insolico Bioinformatically predicted

Overview

Name   micA   Type   Regulator
Locus tag   R4710_RS00645 Genome accession   NZ_CP137101
Coordinates   123036..123740 (-) Length   234 a.a.
NCBI ID   WP_000722076.1    Uniprot ID   Q9S1K0
Organism   Streptococcus pneumoniae strain 16P2012-2     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 118036..128740
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  R4710_RS00615 - 118225..119211 (+) 987 WP_000204727.1 L-lactate dehydrogenase -
  R4710_RS00620 - 119474..120247 (-) 774 WP_044811410.1 potassium channel family protein -
  R4710_RS00625 - 120294..120548 (-) 255 WP_001823540.1 type II toxin-antitoxin system RelE/ParE family toxin -
  R4710_RS00630 relB 120550..120792 (-) 243 WP_000208080.1 type II toxin-antitoxin system RelB family antitoxin -
  R4710_RS00635 vicX 120883..121692 (-) 810 WP_001289493.1 MBL fold metallo-hydrolase Regulator
  R4710_RS00640 micB 121694..123043 (-) 1350 WP_000886210.1 cell wall metabolism sensor histidine kinase VicK Regulator
  R4710_RS00645 micA 123036..123740 (-) 705 WP_000722076.1 response regulator YycF Regulator
  R4710_RS00650 mutY 123795..124970 (-) 1176 WP_000886147.1 A/G-specific adenine glycosylase -
  R4710_RS00655 - 125067..125192 (+) 126 WP_001818232.1 hypothetical protein -
  R4710_RS00660 - 125298..126968 (-) 1671 WP_317804825.1 formate--tetrahydrofolate ligase -
  R4710_RS00665 coaB 127198..127887 (+) 690 WP_000699503.1 phosphopantothenate--cysteine ligase -
  R4710_RS00670 coaC 127899..128450 (+) 552 WP_001284130.1 phosphopantothenoylcysteine decarboxylase -

Sequence

Protein


Download         Length: 234 a.a.        Molecular weight: 26815.63 Da        Isoelectric Point: 4.7164

>NTDB_id=895146 R4710_RS00645 WP_000722076.1 123036..123740(-) (micA) [Streptococcus pneumoniae strain 16P2012-2]
MKKILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKTSSVPILMLSA
KDSEFDKVIGLELGADDYVTKPFSNRELQARVKALLRRSQPMPVDGQEADSKPQPIQIGDLEIVPDAYVAKKYGEELDLT
HREFELLYHLASHTGQVITREHLLETVWGYDYFGDVRTVDVTVRRLREKIEDTPSRPEYILTRRGVGYYMRNNA

Nucleotide


Download         Length: 705 bp        

>NTDB_id=895146 R4710_RS00645 WP_000722076.1 123036..123740(-) (micA) [Streptococcus pneumoniae strain 16P2012-2]
ATGAAAAAAATACTAATTGTAGATGATGAGAAACCAATCTCGGATATTATCAAGTTTAATATGACCAAGGAAGGTTACGA
AGTTGTAACTGCTTTTAATGGTCGTGAAGCGCTAGAGCAATTTGAAGCAGAGCAACCAGATATTATTATTCTGGATTTGA
TGCTTCCAGAAATTGATGGTTTAGAAGTTGCTAAGACCATTCGTAAGACAAGCAGTGTGCCCATTCTTATGCTTTCAGCC
AAAGATAGTGAATTTGATAAGGTTATCGGTTTGGAACTTGGGGCAGATGACTATGTAACGAAACCCTTCTCCAATCGTGA
GTTGCAGGCACGTGTTAAAGCTCTTCTGCGTCGTTCTCAACCTATGCCAGTAGATGGGCAGGAAGCAGATAGTAAACCTC
AACCTATCCAAATTGGGGATTTAGAAATTGTTCCAGACGCCTACGTGGCTAAAAAATATGGCGAAGAACTAGACTTAACC
CATCGTGAATTTGAGCTTTTGTATCATTTAGCATCGCATACAGGTCAAGTCATCACGCGCGAACACTTGCTTGAGACTGT
CTGGGGTTATGACTATTTTGGTGATGTCCGTACAGTTGATGTGACTGTACGACGTCTGCGTGAGAAGATTGAAGATACGC
CCAGCCGACCAGAGTATATCTTGACGCGCCGTGGTGTAGGGTATTACATGAGAAATAATGCTTGA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(4-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(154-229)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  PDB 1NXS
  PDB 2A9O
  PDB 2A9P

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  micA Streptococcus pneumoniae Cp1015

100

100

1
  vicR Streptococcus mutans UA159

78.541

99.573

0.782
  covR Streptococcus salivarius strain HSISS4

44.156

98.718

0.436
  covR Lactococcus lactis subsp. lactis strain DGCC12653

43.478

98.291

0.427
  scnR Streptococcus mutans UA159

38.197

99.573

0.38