Detailed information    

insolico Bioinformatically predicted

Overview

Name   comE/blpR   Type   Regulator
Locus tag   R4703_RS08585 Genome accession   NZ_CP137100
Coordinates   1586777..1587514 (+) Length   245 a.a.
NCBI ID   WP_001219147.1    Uniprot ID   B1IA60
Organism   Streptococcus pneumoniae strain LYP     
Function   activate transcription of early competence genes; regulation of comX expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 1581777..1592514
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  R4703_RS08555 - 1583109..1583396 (-) 288 WP_000777760.1 hypothetical protein -
  R4703_RS08560 - 1583406..1583816 (-) 411 WP_001278301.1 HIT family protein -
  R4703_RS08565 pptA 1583884..1584615 (+) 732 WP_000889919.1 ABC transporter ATP-binding protein Regulator
  R4703_RS08570 - 1584612..1585661 (+) 1050 WP_000653766.1 ABC transporter permease -
  R4703_RS08575 - 1585829..1586158 (-) 330 WP_000132572.1 hypothetical protein -
  R4703_RS08580 - 1586434..1586772 (+) 339 WP_000876676.1 LytTR family DNA-binding domain-containing protein -
  R4703_RS08585 comE/blpR 1586777..1587514 (+) 738 WP_001219147.1 response regulator transcription factor Regulator
  R4703_RS08590 - 1587528..1588868 (+) 1341 WP_001028044.1 sensor histidine kinase -
  R4703_RS08595 blpC 1588910..1589065 (-) 156 WP_000358817.1 quorum-sensing system pheromone BlpC -
  R4703_RS08600 - 1589122..1590483 (-) 1362 Protein_1651 bacteriocin secretion accessory protein -
  R4703_RS08605 comA/nlmT 1590494..1592170 (-) 1677 WP_196299874.1 peptide cleavage/export ABC transporter Regulator

Sequence

Protein


Download         Length: 245 a.a.        Molecular weight: 28828.93 Da        Isoelectric Point: 6.0454

>NTDB_id=895130 R4703_RS08585 WP_001219147.1 1586777..1587514(+) (comE/blpR) [Streptococcus pneumoniae strain LYP]
MRIFVLEDDFSQQTRIETTIEKLLKEHHITPSSFEVFGKPDQLLAEVHEKGAHQLFFLDIEIRNEEMKGLEVARKIREQD
PYALIVFVTTHSEFMPLSFRYQVSALDYIDKALSTEEFESRIETALLYANSQDSKSLAEDCFYFKSKFAQFQYPFKEVYY
LETSPRPHRVILYTKTDRLEFTASLEEVFKQEPRLLQCHRSFLINPANVVHLDKKEKLLFFPNGGSCLIARYKVREVSEA
INNLH

Nucleotide


Download         Length: 738 bp        

>NTDB_id=895130 R4703_RS08585 WP_001219147.1 1586777..1587514(+) (comE/blpR) [Streptococcus pneumoniae strain LYP]
ATGAGAATATTTGTTTTAGAGGATGATTTTTCCCAACAGACTAGGATTGAAACGACGATTGAGAAACTCTTGAAGGAACA
TCATATCACTCCCAGCTCTTTTGAGGTATTTGGCAAGCCAGACCAACTGCTGGCAGAGGTGCATGAGAAGGGGGCCCATC
AGCTATTCTTTTTGGATATTGAGATTCGAAATGAGGAGATGAAGGGGCTGGAAGTGGCTAGAAAGATTCGGGAACAAGAC
CCCTATGCCCTGATTGTCTTTGTGACGACTCACTCGGAGTTTATGCCCCTGTCCTTTCGCTACCAAGTGTCTGCTCTGGA
CTATATTGATAAGGCCCTTTCGACAGAGGAGTTTGAATCTCGAATCGAGACAGCCCTCCTCTATGCCAATAGTCAAGATA
GTAAAAGTCTGGCGGAAGATTGCTTTTACTTTAAATCAAAATTTGCCCAATTTCAGTATCCTTTTAAAGAGGTTTACTAT
CTCGAAACATCCCCAAGACCCCATCGTGTTATTCTCTATACCAAGACAGACAGGCTGGAATTTACAGCGAGTTTAGAGGA
GGTTTTCAAGCAGGAACCCCGTCTCTTGCAGTGCCATCGCTCTTTTCTCATCAATCCTGCAAATGTGGTGCATTTGGATA
AGAAAGAAAAACTCCTTTTCTTTCCCAATGGTGGAAGTTGTCTGATCGCGCGTTATAAGGTCAGGGAAGTGTCTGAGGCT
ATTAATAACTTACACTGA

Domains

Predicted by InterproScan.

LytTr DNA-binding domain (LytTR)

(151-241)

Response regulator receiver domain (Response_reg)

(3-122)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB B1IA60

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comE/blpR Streptococcus mutans UA159

54.321

99.184

0.539
  comE/comE1 Streptococcus equinus JB1

43.882

96.735

0.424
  comE/comE2 Streptococcus equinus JB1

38.843

98.776

0.384
  comE Streptococcus infantis strain Atu-4

36.179

100

0.363