Detailed information NTG0893729

Bioinformatically predicted

Overview

• Name: comA/nlmT
• Type: Regulator
• Locus tag: R3H61_RS07090
• Genome accession: NZ_CP136951
• Coordinates: 1430282..1432435 (+)
• Length: 717 a.a.
• NCBI ID: WP_129284363.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain Spyo09
• Function: transport of ComC (predicted from homology) Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type	MGE coordinates	Gene coordinates	Relative position	Distance (bp)
IScluster/Tn	1424321..1440355	1430282..1432435	within	0

Gene organization within MGE regions

Location: 1424321..1440355

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
R3H61_RS07040 (R3H61_07045)	-	1424321..1425511 (+)	1191	WP_002299749.1	IS256-like element ISLgar5 family transposase	-
R3H61_RS07045 (R3H61_07050)	-	1425551..1425841 (-)	291	Protein_1335	hypothetical protein	-
R3H61_RS07050 (R3H61_07055)	-	1426035..1426316 (-)	282	WP_111705488.1	hypothetical protein	-
R3H61_RS07055 (R3H61_07060)	-	1426366..1426560 (-)	195	WP_002990768.1	hypothetical protein	-
R3H61_RS07060 (R3H61_07065)	-	1426854..1427054 (-)	201	WP_003060803.1	class IIb bacteriocin, lactobin A/cerein 7B family	-
R3H61_RS07065 (R3H61_07070)	-	1427067..1427294 (-)	228	WP_002992018.1	Blp family class II bacteriocin	-
R3H61_RS07070 (R3H61_07075)	-	1427612..1428297 (+)	686	Protein_1340	transposase	-
R3H61_RS07075 (R3H61_07080)	-	1428517..1428699 (-)	183	WP_002987564.1	class IIb bacteriocin, lactobin A/cerein 7B family	-
R3H61_RS07080 (R3H61_07085)	-	1428714..1428959 (-)	246	WP_002994504.1	Blp family class II bacteriocin	-
R3H61_RS07085 (R3H61_07090)	-	1429146..1429831 (-)	686	Protein_1343	transposase	-
R3H61_RS07090 (R3H61_07095)	comA/nlmT	1430282..1432435 (+)	2154	WP_129284363.1	peptide cleavage/export ABC transporter	Regulator
R3H61_RS07095 (R3H61_07100)	-	1432446..1433810 (+)	1365	WP_330554621.1	bacteriocin secretion accessory protein	-
R3H61_RS07100 (R3H61_07105)	-	1433887..1434012 (+)	126	WP_011017462.1	ComC/BlpC family leader-containing pheromone/bacteriocin	-
R3H61_RS07105 (R3H61_07110)	-	1434236..1435426 (-)	1191	WP_002299749.1	IS256-like element ISLgar5 family transposase	-
R3H61_RS07110 (R3H61_07115)	-	1435465..1436838 (-)	1374	WP_330554622.1	sensor histidine kinase	-
R3H61_RS07115 (R3H61_07120)	comE/blpR	1436839..1437588 (-)	750	WP_030126108.1	response regulator transcription factor	Regulator
R3H61_RS07120 (R3H61_07125)	-	1437823..1439316 (-)	1494	WP_373935149.1	IS1182 family transposase	-

Sequence

Protein

• Length: 717 a.a.
• Molecular weight: 80562.50 Da
• Isoelectric Point: 7.0109

>NTDB_id=893729 R3H61_RS07090 WP_129284363.1 1430282..1432435(+) (comA/nlmT) [Streptococcus pyogenes strain Spyo09]
MISYRKTFVAQIDARDCGVAALASIAKYYGSDYSLAHLRELAKTNKEGTTALGIVKAAKLMGFETRAIQADMTLFDIEDV
PYPFIVHVNKEGKFQHYYVIYQNKKNYLIIGDPDSTVKVTKMTKERFTSEWTGVAIFLAPEPSYKPHKDKKNGLISFLPL
IFKQRSLIFYIILASLLVTLINIVGSYYLQGILDDYIPNQLKSTLGIISIGLIITYILQQMMSFSRDYLLTVLSQRLSID
VILSYIRHIFELPMSFFATRRTGEIISRFTDANAIIDALASTILSLFLDVSILTIVGTVLLVQNTNLFLLSLVSVPLYIV
IIFIFMHPFEKMNNDVMQSNSMVSSAIIEDINGIETIKSLTSEENRYQKIDSEFVDYLDKSFKLSKYSILQSSLKQGAQL
ILNVIVLWFGAKLVMGGKISVGQLITFNTLLSYFTNPLENIINLQTKLQSAKVANNRLNEVYLVDSEFQEAGTLVNQELL
HGDIQFEELSYKYGFGRDTLSNINLTIKQGDKVSLVGISGSGKTTLAKMIVNFFEPYNGRITINHNDLKMIDKKSLRQHI
NYLPQQAYIFNGSILENLTLGANDCTSHEDILRACEVAEIRQDIEQMPMGYQTELSDGAGLSGGQKQRIALARALLTKAP
VLILDEATSGLDVLTEKRVIDNLLAMTDKTIIFVAHRLSISARTNQVIVLDEGKIIEIGSHQELMTKQGFYHHLFSS

Nucleotide

• Length: 2154 bp

>NTDB_id=893729 R3H61_RS07090 WP_129284363.1 1430282..1432435(+) (comA/nlmT) [Streptococcus pyogenes strain Spyo09]
ATGATATCCTATCGAAAAACATTTGTTGCTCAGATTGATGCTAGAGACTGTGGTGTGGCTGCTCTTGCTTCCATCGCTAA
ATATTACGGTTCAGACTACTCTTTAGCTCATTTAAGAGAGTTAGCTAAAACAAATAAAGAGGGAACAACAGCGCTTGGCA
TCGTCAAAGCTGCCAAATTAATGGGATTTGAAACAAGAGCTATTCAAGCAGACATGACCCTCTTTGATATAGAAGATGTC
CCTTATCCTTTTATTGTTCATGTTAATAAAGAAGGTAAATTCCAACACTACTATGTCATCTATCAAAACAAAAAAAATTA
TCTGATAATCGGCGACCCTGACTCGACAGTAAAAGTCACTAAGATGACAAAGGAGCGATTTACTTCTGAATGGACGGGTG
TCGCTATTTTTCTAGCACCCGAGCCCAGCTACAAGCCTCATAAGGACAAAAAGAACGGTCTAATAAGCTTTTTACCTCTC
ATTTTTAAACAGCGATCTCTGATTTTCTATATCATATTAGCTAGCCTACTCGTTACTCTGATTAATATTGTAGGTTCTTA
TTACCTACAAGGTATATTAGATGACTATATTCCAAATCAACTGAAATCAACACTCGGCATTATTTCAATTGGTCTTATCA
TTACCTATATCCTCCAACAGATGATGAGTTTTTCGCGAGATTATCTCCTGACTGTACTGAGTCAGCGATTAAGCATTGAT
GTTATTTTATCCTATATTCGTCATATTTTTGAGCTTCCCATGTCTTTTTTTGCAACTCGCAGAACAGGAGAAATCATCTC
ACGTTTTACAGATGCTAATGCTATTATTGATGCACTCGCTTCTACTATTTTGTCTCTTTTTCTTGATGTCAGTATTTTAA
CTATCGTAGGGACAGTCCTGTTAGTGCAAAATACCAATCTTTTTCTTCTATCTCTGGTTTCAGTCCCTCTATATATTGTT
ATTATCTTTATATTTATGCACCCATTTGAAAAGATGAATAATGATGTCATGCAGAGTAACTCTATGGTTAGCTCAGCCAT
TATCGAAGATATCAATGGCATTGAAACTATTAAATCACTGACCAGTGAAGAAAATCGTTATCAGAAAATTGATAGTGAAT
TTGTGGACTATCTGGATAAATCCTTCAAGTTAAGTAAGTACTCTATTTTACAAAGCAGTCTCAAACAAGGGGCGCAACTA
ATCCTTAACGTGATAGTCTTATGGTTTGGGGCCAAATTAGTTATGGGAGGAAAAATTTCTGTTGGTCAGTTGATTACGTT
TAATACTCTCTTATCTTATTTTACCAATCCTTTAGAAAATATCATTAATCTTCAAACTAAACTGCAATCAGCCAAGGTAG
CTAATAATCGTCTCAATGAAGTTTACCTAGTCGATTCTGAGTTTCAAGAGGCTGGGACATTAGTCAATCAAGAATTATTA
CACGGAGACATTCAATTTGAAGAGTTATCCTATAAATATGGCTTTGGACGCGATACTCTATCAAATATTAATCTCACTAT
TAAGCAAGGGGACAAAGTTAGCCTTGTTGGTATTAGTGGATCTGGTAAAACGACTCTAGCTAAAATGATTGTTAATTTTT
TTGAGCCTTATAACGGCCGAATTACCATTAATCATAATGACTTAAAAATGATTGATAAAAAAAGTCTTCGCCAACATATT
AATTATCTCCCCCAACAAGCCTATATTTTTAATGGTTCTATTTTAGAAAATTTAACCTTAGGTGCTAATGACTGTACTAG
TCATGAAGATATTCTAAGAGCTTGTGAGGTTGCAGAAATTCGACAAGATATTGAACAAATGCCTATGGGCTATCAAACAG
AGCTTTCTGATGGTGCCGGACTCTCAGGAGGCCAAAAGCAACGAATTGCACTTGCCAGAGCTCTCCTAACCAAGGCGCCT
GTGCTTATTCTAGATGAGGCTACAAGCGGTCTTGACGTACTAACTGAAAAGAGGGTTATTGATAATCTTTTGGCTATGAC
GGATAAAACTATTATTTTCGTAGCTCATCGTCTCAGCATTTCAGCGCGGACCAATCAAGTCATTGTGCTTGATGAGGGTA
AAATTATTGAAATAGGATCTCATCAAGAATTAATGACTAAACAAGGTTTCTATCATCATTTATTTAGTAGTTAA

Domains

Predicted by InterproScan.

• ABC transporter transmembrane region (ABC_membrane) (168-438)

• ABC transporter (ABC_tran) (500-649)

• Peptidase C39 family (Peptidase_C39) (7-142)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comA/nlmT	Streptococcus mutans UA159	72.587	99.721	0.724
comA	Streptococcus mitis NCTC 12261	67.367	99.582	0.671
comA	Streptococcus mitis SK321	66.947	99.582	0.667
comA	Streptococcus pneumoniae Rx1	66.947	99.582	0.667
comA	Streptococcus pneumoniae D39	66.947	99.582	0.667
comA	Streptococcus pneumoniae R6	66.947	99.582	0.667
comA	Streptococcus pneumoniae TIGR4	66.667	99.582	0.664
comA	Streptococcus gordonii str. Challis substr. CH1	65.738	100	0.658