Detailed information    

insolico Bioinformatically predicted

Overview

Name   comR   Type   Regulator
Locus tag   R3H37_RS00330 Genome accession   NZ_CP136948
Coordinates   52996..53907 (+) Length   303 a.a.
NCBI ID   WP_014635220.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain Spyo01     
Function   activate transcription of comX (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
IS/Tn 53962..55152 52996..53907 flank 55


Gene organization within MGE regions


Location: 52996..55152
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  R3H37_RS00330 (R3H37_00330) comR 52996..53907 (+) 912 WP_014635220.1 helix-turn-helix domain-containing protein Regulator
  R3H37_RS00335 (R3H37_00335) - 53962..55152 (-) 1191 WP_002299749.1 IS256-like element ISLgar5 family transposase -

Sequence

Protein


Download         Length: 303 a.a.        Molecular weight: 35925.63 Da        Isoelectric Point: 4.9349

>NTDB_id=893576 R3H37_RS00330 WP_014635220.1 52996..53907(+) (comR) [Streptococcus pyogenes strain Spyo01]
MLEHFGGKVKVLRLEKRISREDLCGDESELSVRQLARIELGQSIPSLSKVIFIAKALNVSVGYLTDGADLELPKRYKELK
YLILRTPTYMDDGKLQVREEQFDEIFEDYYDKLPEEEKVAVDIIQAKFEVYQTGDINFGYSILKEFLPQLKRKSIYNLNE
LLLIDLYLIILVVSHFSDDIFDVQFYEEITESMLKQHNNLPLEDLFLLNNILLSCADTYIRLKMFGRLKETLQLSHFIMS
TIQDFQKMPMYCMYEWKLSIFYLKDINRARNYFEQSILFTQMTGDTYLVQKLRGEWNKDIHYI

Nucleotide


Download         Length: 912 bp        

>NTDB_id=893576 R3H37_RS00330 WP_014635220.1 52996..53907(+) (comR) [Streptococcus pyogenes strain Spyo01]
ATGTTAGAACATTTTGGTGGAAAAGTAAAAGTGTTAAGACTTGAAAAGAGGATTAGTCGCGAGGACTTGTGTGGGGATGA
GTCTGAACTTTCTGTTCGTCAATTAGCACGGATAGAACTAGGTCAATCCATACCAAGTTTAAGTAAGGTTATTTTTATTG
CAAAAGCCTTAAACGTTAGTGTCGGTTACTTAACTGATGGTGCTGATTTAGAACTACCTAAGCGTTACAAAGAATTAAAA
TACCTTATCTTAAGGACACCAACTTACATGGATGATGGAAAATTACAAGTACGAGAAGAGCAGTTTGATGAAATTTTTGA
GGATTATTATGATAAATTACCAGAGGAAGAGAAAGTTGCTGTTGATATTATCCAAGCAAAATTTGAAGTTTATCAAACCG
GAGATATTAATTTCGGATATAGTATTTTAAAAGAATTTCTACCACAGCTAAAAAGAAAATCTATCTATAATTTAAATGAA
TTATTACTTATAGATTTGTATTTGATTATTCTGGTAGTTTCTCATTTTTCAGATGATATATTTGATGTACAGTTTTATGA
AGAAATAACAGAGAGCATGTTAAAACAACACAATAATTTACCATTGGAAGATTTATTTTTACTGAATAATATCTTATTAT
CTTGTGCGGACACTTATATTCGTTTGAAGATGTTCGGTCGTCTAAAAGAAACATTACAACTTAGCCACTTTATAATGTCA
ACTATTCAAGATTTTCAAAAAATGCCTATGTATTGTATGTATGAATGGAAGCTATCTATTTTTTATTTGAAAGATATTAA
CCGAGCACGGAATTACTTTGAACAGTCTATTTTATTTACTCAAATGACAGGAGATACATATTTAGTTCAAAAATTACGGG
GAGAATGGAATAAAGATATTCATTATATTTAA

Domains

Predicted by InterproScan.

Helix-turn-helix (HTH_3)

(12-64)

ComR tetratricopeptide (ComR_TPR)

(73-296)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comR Streptococcus pyogenes MGAS315

99.34

100

0.993
  comR Streptococcus pyogenes MGAS8232

58.472

99.34

0.581
  comR Streptococcus mutans UA159

47.492

98.68

0.469
  comR Streptococcus infantarius subsp. infantarius ATCC BAA-102

46.441

97.36

0.452
  comR Streptococcus suis P1/7

37.374

98.02

0.366
  comR Streptococcus suis 05ZYH33

37.374

98.02

0.366