Detailed information NTG0893338

Bioinformatically predicted

Overview

• Name: comA
• Type: Regulator
• Locus tag: R2J99_RS10225
• Genome accession: NZ_CP136906
• Coordinates: 2114322..2116481 (+)
• Length: 719 a.a.
• NCBI ID: WP_066035721.1
• Uniprot ID: A0A1C2G7V5
• Organism: Limosilactobacillus reuteri strain P43
• Function: processing and transport of ComC (predicted from homology) Competence regulation

Genomic Context

Location: 2109322..2121481

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
R2J99_RS10200 (R2J99_10200)	-	2109663..2110340 (+)	678	WP_066035719.1	dihydrofolate reductase family protein	-
R2J99_RS10205 (R2J99_10205)	-	2110554..2110862 (-)	309	WP_066035720.1	hypothetical protein	-
R2J99_RS10210 (R2J99_10210)	-	2111400..2111735 (+)	336	WP_225356783.1	DUF3278 domain-containing protein	-
R2J99_RS10215 (R2J99_10215)	-	2112370..2113524 (+)	1155	WP_225355632.1	GHKL domain-containing protein	-
R2J99_RS10220 (R2J99_10220)	-	2113537..2114310 (+)	774	WP_065867368.1	LytTR family DNA-binding domain-containing protein	-
R2J99_RS10225 (R2J99_10225)	comA	2114322..2116481 (+)	2160	WP_066035721.1	peptide cleavage/export ABC transporter	Regulator
R2J99_RS10230 (R2J99_10230)	-	2116546..2117922 (-)	1377	WP_066035722.1	IS3 family transposase	-
R2J99_RS10235 (R2J99_10235)	-	2118163..2118522 (+)	360	WP_225356787.1	dihydrofolate reductase family protein	-
R2J99_RS10240 (R2J99_10240)	-	2119059..2119247 (-)	189	WP_065867035.1	Blp family class II bacteriocin	-
R2J99_RS10245 (R2J99_10245)	-	2119261..2119467 (-)	207	WP_065867034.1	Blp family class II bacteriocin	-
R2J99_RS10250 (R2J99_10250)	-	2120727..2120924 (+)	198	Protein_1959	hypothetical protein	-

Sequence

Protein

• Length: 719 a.a.
• Molecular weight: 81210.07 Da
• Isoelectric Point: 9.9096

>NTDB_id=893338 R2J99_RS10225 WP_066035721.1 2114322..2116481(+) (comA) [Limosilactobacillus reuteri strain P43]
MYNFRRHYINQVDEADCGVAALAMILHNYGSKISLATLRKFTKTTTDGTTALGIVKAAEKLKMDVEAYQADASLFDSKDV
IYPFIAHLIKKDSGLLHYCVVFKSSKKHIFIADPDPNIQVKRIPKVNFFEEWTGIAIFAKPGKNYKPIQEKIPTFKRLCR
PLFQQKALLFGIITAAFIVTFLNILNSYYLQTLLDTLIPNKLQDPLAIISIGLLFAYLFNSLFTFSRDYLLAILGQKLSK
IIILNYIKHVLRLPMAFFSTRKTGDILSRFTDANKVIDALVSAIISIFLDATILIIIGTVLALQDIRLFGITMLIIPIYS
LIIFSFTSNFRKLNQKEMESNATVSASIIEDIRGIETIKSLNCEEVRSNKITNEFNDFLHKSLVHTRLNNIQQGLKTFVQ
LSLNLIILWVGANQVIKNELSIGQLMTYNALLIYFTTSLQNIINLQPKIQSAQVANSRLNEIYMVKDEFENTTKHNHSLK
NGTIELKNVSYSYEYNSPILQNINLKIKSGEKLTIVGLSGSGKSTLMKLLVNYFDVSNGEILINNLNILNISKKQLRSFI
NYVPQIPYTFSGTIKENLLLGNRTTINEKDIVTACKTAMIHDDIMHLPLGYDSKLDENATTFSGGQKQRLTIARALLSPA
KVLIFDESTNGLDILTEEKIIKNLMALSSKTIIFIAHRLSIARITNNITVIDNGKIVEQGSHKELLKNKSLYFKLMQTQ

Nucleotide

• Length: 2160 bp

>NTDB_id=893338 R2J99_RS10225 WP_066035721.1 2114322..2116481(+) (comA) [Limosilactobacillus reuteri strain P43]
ATGTATAACTTTAGAAGACACTATATAAATCAAGTGGATGAAGCTGATTGTGGAGTAGCAGCACTAGCAATGATTCTTCA
TAATTACGGCTCTAAAATTTCATTAGCAACTCTGCGAAAATTTACAAAAACCACTACTGATGGAACTACTGCACTTGGGA
TTGTAAAAGCAGCAGAAAAGTTAAAAATGGATGTTGAAGCATATCAAGCAGATGCTAGTTTATTTGATTCAAAAGATGTA
ATTTATCCTTTTATTGCTCATCTCATAAAAAAAGACAGTGGCCTACTTCACTATTGTGTTGTTTTTAAAAGTTCCAAAAA
ACATATTTTTATTGCTGATCCTGATCCTAATATACAAGTTAAACGTATTCCTAAGGTCAATTTTTTTGAAGAATGGACCG
GAATTGCTATTTTTGCAAAACCAGGTAAGAACTATAAACCTATTCAGGAAAAAATCCCCACTTTTAAAAGATTATGTCGA
CCACTTTTTCAACAAAAAGCCCTACTTTTTGGAATTATTACAGCAGCTTTTATTGTAACGTTTCTTAATATTTTAAATTC
TTATTATCTACAAACTTTACTTGACACATTAATTCCTAATAAACTTCAAGATCCTTTAGCAATTATTAGTATTGGACTAT
TGTTCGCCTATCTTTTTAACTCTCTATTTACTTTTTCTCGGGATTACTTATTAGCAATTCTAGGGCAGAAACTATCTAAA
ATTATTATCCTAAACTATATAAAGCACGTTTTAAGACTTCCAATGGCATTTTTCTCTACTAGAAAGACTGGTGATATTCT
ATCTCGTTTTACTGACGCGAATAAAGTAATTGATGCTCTTGTCAGTGCAATTATATCTATCTTTTTAGATGCCACTATTT
TAATAATTATAGGCACAGTTCTTGCTTTACAGGATATTAGATTATTCGGAATTACTATGCTTATTATTCCTATTTATTCT
CTGATAATTTTTTCATTTACTAGTAATTTTAGGAAACTAAACCAAAAAGAAATGGAAAGTAACGCAACAGTAAGTGCATC
AATTATAGAAGATATTAGAGGAATCGAAACTATTAAATCTCTTAATTGCGAAGAAGTTCGTTCTAACAAGATTACTAACG
AATTTAATGATTTCTTACATAAGTCATTAGTCCACACTAGATTAAATAATATACAACAAGGACTCAAAACTTTTGTTCAA
CTTTCGCTTAACCTTATCATTTTATGGGTTGGAGCTAACCAGGTTATTAAAAATGAATTATCAATTGGGCAATTAATGAC
CTATAATGCATTACTAATTTACTTTACAACTTCCCTTCAAAACATCATTAACCTACAACCCAAAATCCAAAGTGCGCAAG
TTGCTAATAGTCGTTTAAATGAGATATACATGGTTAAAGACGAATTTGAAAATACAACTAAACATAATCATTCATTAAAA
AATGGAACAATCGAGTTAAAAAATGTTTCTTATAGCTACGAGTACAATTCTCCTATATTACAAAATATTAACTTAAAAAT
TAAGTCTGGCGAAAAACTGACAATCGTAGGTCTAAGTGGCTCTGGTAAATCAACCTTGATGAAATTATTAGTAAATTATT
TTGATGTTTCAAATGGTGAAATTCTTATTAATAATCTAAATATTTTAAATATCTCTAAAAAGCAGTTACGTTCTTTTATT
AATTATGTGCCACAAATTCCTTATACATTTTCAGGAACGATTAAAGAAAACTTATTATTAGGAAATCGTACTACGATTAA
TGAAAAAGATATTGTAACTGCATGCAAAACCGCTATGATACATGATGATATAATGCATTTACCGTTGGGATATGATAGTA
AATTAGATGAAAATGCAACAACTTTTTCTGGAGGGCAGAAGCAGCGACTTACAATAGCGAGAGCATTACTCTCACCAGCA
AAAGTACTCATTTTCGATGAATCTACTAACGGACTTGATATTTTAACAGAAGAGAAAATAATCAAAAATCTCATGGCATT
ATCTTCAAAAACAATTATCTTTATTGCCCATCGTCTTTCAATAGCTCGAATTACAAATAATATTACAGTTATTGATAATG
GCAAAATTGTTGAACAGGGTTCTCATAAAGAACTTCTCAAAAATAAATCGTTATATTTTAAACTTATGCAAACACAATAA

Domains

Predicted by InterproScan.

• ABC transporter transmembrane region (ABC_membrane) (170-439)

• ABC transporter (ABC_tran) (500-650)

• Peptidase C39 family (Peptidase_C39) (7-143)

3D structure

• AlphaFold DB: A0A1C2G7V5

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comA	Streptococcus gordonii str. Challis substr. CH1	51.049	99.444	0.508
comA	Streptococcus mitis NCTC 12261	50.49	99.444	0.502
comA	Streptococcus pneumoniae Rx1	50.07	99.444	0.498
comA	Streptococcus pneumoniae D39	50.07	99.444	0.498
comA	Streptococcus pneumoniae TIGR4	50.07	99.444	0.498
comA	Streptococcus pneumoniae R6	50.07	99.444	0.498
comA	Streptococcus mitis SK321	50.07	99.444	0.498
comA/nlmT	Streptococcus mutans UA159	49.65	99.444	0.494