Detailed information    

insolico Bioinformatically predicted

Overview

Name   comA/nlmT   Type   Regulator
Locus tag   F6I35_RS03345 Genome accession   NZ_CP136160
Coordinates   613418..615568 (-) Length   716 a.a.
NCBI ID   WP_024051970.1    Uniprot ID   A0A412PPB0
Organism   Streptococcus anginosus strain UMB8616     
Function   transport of ComC (predicted from homology)   
Competence regulation

Genomic Context

Location: 608418..620568
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  F6I35_RS03320 (F6I35_0003320) - 608853..609566 (+) 714 WP_150866966.1 CPBP family intramembrane glutamic endopeptidase -
  F6I35_RS03325 (F6I35_0003325) - 609707..610452 (+) 746 Protein_617 response regulator transcription factor -
  F6I35_RS03330 (F6I35_0003330) - 610486..611781 (+) 1296 WP_024051972.1 sensor histidine kinase -
  F6I35_RS03335 (F6I35_0003335) - 611803..611952 (-) 150 WP_022526763.1 ComC/BlpC family leader-containing pheromone/bacteriocin -
  F6I35_RS03340 (F6I35_0003340) - 612046..613407 (-) 1362 WP_024051971.1 bacteriocin secretion accessory protein -
  F6I35_RS03345 (F6I35_0003345) comA/nlmT 613418..615568 (-) 2151 WP_024051970.1 peptide cleavage/export ABC transporter Regulator
  F6I35_RS03350 (F6I35_0003350) - 615850..616905 (+) 1056 WP_024051969.1 serine hydrolase -
  F6I35_RS03355 (F6I35_0003355) - 617041..617727 (+) 687 WP_024051968.1 Crp/Fnr family transcriptional regulator -
  F6I35_RS03360 (F6I35_0003360) arcA 618048..619277 (+) 1230 WP_021001457.1 arginine deiminase -
  F6I35_RS03365 (F6I35_0003365) argF 619301..620317 (+) 1017 WP_003028184.1 ornithine carbamoyltransferase -

Sequence

Protein


Download         Length: 716 a.a.        Molecular weight: 80647.14 Da        Isoelectric Point: 9.3981

>NTDB_id=888955 F6I35_RS03345 WP_024051970.1 613418..615568(-) (comA/nlmT) [Streptococcus anginosus strain UMB8616]
MNFKKSFVPQIDARDCGVAALASIAKYYGSNYSLAHLRELAKTNKEGTTALGIVKAAKEMGFETRPIQADMTLFDTEELP
YPFIAHVNKDGKLQHYYVVYKNEQKHLLIGDPDPTVKITKISKEQFTKEWTGVAIFLAPKPSYKPHKDKKNGLASFLPLI
FKQRSLIFYIVLASLLVTLINIVGSYYLQSVLDEYIPNQMKSTLGIISIGLIIAYILQQMMSFSRDYLLTVLSQRLTIDV
ILSYIRHIFELPMSFFAMRRTGEIISRFTDANSIIDALASTILSFFLDLFIVMIVGSVLLLQNVNLFLLTLLAIPIYALI
IFVFMKPFEKMNNDVMQSNAMVHSAIIEDINGIETIKSLTSEESRYQKIDSEFVDYLDKTFKLSKYSIMQTALKQGAQFV
LNVVILWVGASLVMSQKISIGQLITFNALLSYFTSPLESIINLQTKLQSAKVANHRLNEVYLVESEFKTKQVLTEKNFLA
GDITFHNVSYKYGFGRDTLSDISLTIKKGDKISLFGISGSGKTTLAKMIVHFYEPYQGQIRLNGNDLKTIDKKVLRQYIN
YLPQQAYIFSGSILDNLTLGADQTVSQSDILRACEIAEIRSDIEQMPMGYQTELSDGAGLSGGQKQRIALARALLTKSPI
LILDEATSGLDVLTEKKVIDNLMKLPDKTIIFVAHRLSISKRTNQIIVLDQGKVTEIGSHTELIGRKGFYYHLFNK

Nucleotide


Download         Length: 2151 bp        

>NTDB_id=888955 F6I35_RS03345 WP_024051970.1 613418..615568(-) (comA/nlmT) [Streptococcus anginosus strain UMB8616]
GTGAATTTTAAAAAATCGTTTGTTCCACAAATAGATGCTAGAGATTGTGGTGTTGCTGCTCTGGCTTCCATTGCTAAATA
CTATGGTTCAAATTATTCTTTAGCACACTTGAGAGAGCTCGCAAAGACAAACAAAGAAGGGACAACTGCACTTGGAATTG
TCAAAGCAGCAAAAGAAATGGGCTTTGAAACCCGACCAATCCAAGCAGACATGACATTGTTTGATACAGAAGAGCTTCCC
TATCCTTTCATCGCACATGTCAACAAAGACGGCAAGCTTCAACACTATTATGTCGTTTATAAAAACGAGCAAAAGCACTT
GCTTATCGGTGATCCTGATCCAACTGTCAAAATAACTAAGATTAGCAAAGAACAATTTACTAAAGAATGGACAGGTGTTG
CTATCTTTCTCGCCCCAAAACCTAGCTATAAACCTCATAAGGATAAGAAAAATGGACTTGCTAGCTTTTTACCACTCATC
TTTAAACAGCGTTCTTTGATTTTTTATATTGTCTTAGCTAGTTTGCTCGTGACCCTCATCAACATTGTTGGCTCCTATTA
TCTGCAAAGTGTTTTGGACGAATACATCCCAAATCAGATGAAATCAACTCTTGGGATTATTTCGATTGGACTTATCATTG
CCTACATCTTACAGCAAATGATGAGTTTTTCAAGAGACTACCTGCTAACAGTACTCAGTCAACGATTAACAATTGATGTG
ATTTTGTCTTATATTCGGCATATTTTTGAATTGCCAATGTCCTTTTTTGCGATGAGACGCACTGGAGAGATTATTTCTCG
TTTTACAGATGCCAACTCTATTATTGATGCTCTAGCTTCAACTATCCTGTCTTTCTTTCTTGATTTGTTCATTGTGATGA
TTGTCGGTAGTGTTCTTTTACTGCAAAATGTCAATCTCTTTTTACTCACTTTGCTTGCAATTCCTATCTACGCTCTCATT
ATTTTTGTTTTTATGAAGCCCTTTGAAAAAATGAACAACGATGTTATGCAAAGCAATGCTATGGTACATTCTGCCATTAT
CGAAGATATCAATGGAATTGAAACTATTAAATCCTTAACCAGTGAAGAAAGTCGTTACCAGAAGATTGATAGCGAGTTTG
TTGATTATCTGGATAAAACTTTCAAATTAAGTAAATATTCCATTATGCAGACCGCTCTCAAACAAGGAGCACAATTTGTT
TTGAATGTGGTCATTCTCTGGGTTGGAGCGTCCTTAGTCATGTCTCAAAAGATTTCAATTGGTCAACTGATTACTTTTAA
TGCACTCCTTTCGTATTTTACAAGCCCGCTTGAAAGTATTATCAATCTTCAAACCAAACTGCAATCAGCTAAAGTTGCCA
ATCATCGACTGAATGAAGTTTATCTGGTAGAATCCGAATTCAAAACCAAACAAGTCCTTACGGAGAAAAATTTCTTAGCT
GGTGATATTACTTTTCATAACGTCTCCTATAAATATGGCTTTGGACGAGATACTTTATCAGATATTAGTTTAACTATCAA
GAAGGGAGATAAAATCAGTCTTTTCGGTATTAGCGGTTCGGGAAAAACAACACTTGCTAAGATGATTGTTCATTTTTATG
AGCCTTATCAAGGACAAATTCGCCTCAATGGAAATGACCTCAAGACAATTGATAAGAAAGTTCTTCGGCAATATATCAAC
TACTTACCTCAGCAAGCTTACATCTTTAGTGGTTCCATTCTAGACAACCTCACATTAGGAGCCGATCAAACAGTTTCTCA
ATCAGATATTCTTCGTGCCTGTGAAATTGCAGAAATTCGTTCAGATATCGAACAAATGCCCATGGGATACCAGACAGAAT
TGTCTGACGGAGCTGGATTATCTGGTGGACAAAAGCAACGAATTGCACTTGCACGCGCTCTGCTGACGAAATCTCCCATT
CTCATTTTAGATGAAGCAACGAGTGGATTAGATGTTTTAACAGAGAAAAAAGTCATTGATAATCTCATGAAATTACCCGA
CAAAACCATTATTTTTGTTGCTCATCGTCTCAGCATTTCAAAGCGTACAAATCAGATTATCGTCCTTGACCAAGGAAAAG
TGACTGAAATTGGTTCTCATACTGAATTGATAGGAAGAAAAGGTTTTTATTATCATCTATTTAATAAATAA

Domains

Predicted by InterproScan.

Peptidase C39 family (Peptidase_C39)

(5-141)

ABC transporter (ABC_tran)

(499-648)

ABC transporter transmembrane region (ABC_membrane)

(167-437)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A412PPB0

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comA/nlmT Streptococcus mutans UA159

72.779

99.022

0.721
  comA Streptococcus mitis NCTC 12261

67.181

99.581

0.669
  comA Streptococcus gordonii str. Challis substr. CH1

66.527

100

0.666
  comA Streptococcus mitis SK321

66.76

99.581

0.665
  comA Streptococcus pneumoniae Rx1

66.339

99.581

0.661
  comA Streptococcus pneumoniae D39

66.339

99.581

0.661
  comA Streptococcus pneumoniae R6

66.339

99.581

0.661
  comA Streptococcus pneumoniae TIGR4

65.919

99.581

0.656