Detailed information NTG0888696

Bioinformatically predicted

Overview

• Name: comA
• Type: Regulator
• Locus tag: RWA18_RS10535
• Genome accession: NZ_CP136121
• Coordinates: 2155121..2157313 (-)
• Length: 730 a.a.
• NCBI ID: WP_016383809.1
• Uniprot ID: A0A8E0I3B1
• Organism: Lacticaseibacillus paracasei strain LMG 19719
• Function: processing and transport of ComC (predicted from homology) Competence regulation

Genomic Context

Location: 2150121..2162313

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
RWA18_RS10505 (RWA18_10515)	-	2150291..2150575 (-)	285	WP_003599758.1	bacteriocin immunity protein	-
RWA18_RS10510 (RWA18_10520)	-	2150768..2151062 (-)	295	Protein_2041	bacteriocin immunity protein	-
RWA18_RS10515 (RWA18_10525)	-	2151163..2152518 (-)	1356	WP_003567335.1	threonine/serine exporter ThrE family protein	-
RWA18_RS10520 (RWA18_10530)	-	2152824..2153135 (-)	312	WP_003580849.1	hypothetical protein	-
RWA18_RS10525 (RWA18_10535)	-	2153208..2153557 (-)	350	Protein_2044	hypothetical protein	-
RWA18_RS10530 (RWA18_10540)	-	2153731..2155110 (-)	1380	WP_016366046.1	bacteriocin secretion accessory protein	-
RWA18_RS10535 (RWA18_10545)	comA	2155121..2157313 (-)	2193	WP_016383809.1	peptide cleavage/export ABC transporter	Regulator
RWA18_RS10540 (RWA18_10550)	-	2157779..2157916 (-)	138	WP_003571414.1	bacteriocin-like peptide, LSEI_2386 family	-
RWA18_RS10545 (RWA18_10555)	-	2158285..2159403 (+)	1119	WP_032775417.1	GHKL domain-containing protein	-
RWA18_RS10550 (RWA18_10560)	-	2159408..2160214 (+)	807	WP_003567351.1	LytTR family DNA-binding domain-containing protein	-
RWA18_RS10555 (RWA18_10565)	-	2160576..2160773 (-)	198	WP_003661762.1	hypothetical protein	-
RWA18_RS10560 (RWA18_10570)	-	2161317..2161556 (+)	240	WP_003603311.1	hypothetical protein	-
RWA18_RS10565 (RWA18_10575)	-	2161830..2162003 (-)	174	WP_003599800.1	bacteriocin	-
RWA18_RS10570 (RWA18_10580)	-	2162042..2162215 (-)	174	WP_016365869.1	ComC/BlpC family leader-containing pheromone/bacteriocin	-

Sequence

Protein

• Length: 730 a.a.
• Molecular weight: 81316.58 Da
• Isoelectric Point: 7.0227

>NTDB_id=888696 RWA18_RS10535 WP_016383809.1 2155121..2157313(-) (comA) [Lacticaseibacillus paracasei strain LMG 19719]
MIKYNIKLGQAQYYKRYYTPQVDERDCGVAALNMLLQFNGSDYSLAHLRQLAKTDQEGTTALGIVRAAQALHFETKAVKA
DMTLFDLDDVPYPFLVHVLKRGELLHYYVVFKATKDHILIGDPDPSVAMTWLPKERFAKEWSGVAIFIAPEPQYQLRKED
KGSLFAFVPMLARQKGIIANIIVAAVLITLISIVGSYFLQSIIDTYIPNGMRTTLGMIASGLILAYVLQSVLTYGQNFLM
AVLGQRLSIDVILGYVRHLYELPMSFFSTRRTGEIVSRFSDANKIIDALANTIMTLFLDIWIVLILGIVLGIQNTTLFLV
SLIAVPCYLVIVFAFQRPFNRLNQETMESNAILSSSIIEDLNGIETIKSLTGEKVSYERVDREFVTYLKKSFNYTKADQL
QQAIKGLLKLVLNVVVLWIGASLVMANKMSLGQMLTFNALLAYFTNPLESIINLQPKLQMAKVANNRLNEVYLVESEFKE
QRSLNDRHLIDGAINVTDVSFKYGFGQDVLKQINLEIPENAKYTIVGMSGSGKSTLAKLLVGFYPVDTGKGKITFNGVPI
SDVDLTTLRQYIEYVPQDPFIFSGSVIENLTLGSRSNITEADIEAACSVAEIAGDISNLPQIWQTKLSESGSILSGGQKQ
RLAIARALLSPAKVLIFDESTSSLDTITERKIVDRLLAMTDRTIIFVAHRLTIAAKTEQIVVMDHGAIVEQGNHAELLAK
QGYYARLVSE

Nucleotide

• Length: 2193 bp

>NTDB_id=888696 RWA18_RS10535 WP_016383809.1 2155121..2157313(-) (comA) [Lacticaseibacillus paracasei strain LMG 19719]
ATGATCAAATACAACATAAAGCTCGGCCAAGCACAGTATTACAAGCGTTACTACACGCCTCAGGTGGATGAGCGCGATTG
CGGGGTTGCGGCGCTTAATATGCTGCTGCAATTTAATGGCTCGGATTATTCGCTAGCGCATCTGCGACAATTGGCGAAGA
CGGATCAGGAAGGAACAACAGCGCTAGGGATTGTCCGCGCTGCTCAGGCGCTTCATTTTGAAACCAAGGCTGTCAAGGCG
GATATGACGCTGTTTGATCTTGATGATGTTCCTTATCCGTTTCTTGTCCATGTTTTGAAGCGTGGCGAGTTGCTTCATTA
TTATGTCGTGTTTAAGGCGACAAAGGATCATATCTTGATTGGCGATCCTGATCCATCAGTAGCGATGACCTGGCTTCCCA
AAGAGCGCTTTGCGAAGGAGTGGTCGGGGGTCGCTATTTTTATTGCACCAGAACCGCAATATCAACTACGCAAAGAGGAT
AAAGGCAGTCTTTTTGCGTTTGTGCCGATGCTGGCGCGGCAAAAAGGGATCATTGCCAATATTATTGTCGCCGCTGTGTT
GATCACGTTGATTAGTATTGTCGGGTCTTATTTTCTTCAGTCGATTATTGATACTTATATTCCAAACGGGATGCGCACAA
CTTTGGGAATGATTGCCAGTGGCCTCATCCTCGCTTATGTCCTGCAGTCGGTTTTAACCTATGGGCAAAATTTTTTGATG
GCTGTTTTAGGACAGCGTTTGTCGATTGATGTCATTTTGGGTTACGTTAGGCATCTTTATGAATTACCGATGTCCTTCTT
TTCCACGCGTCGGACTGGGGAAATTGTGTCGCGGTTTTCCGATGCTAATAAGATTATTGATGCGCTGGCAAACACAATTA
TGACCTTGTTTCTTGATATTTGGATTGTCTTAATTTTAGGGATCGTGTTAGGCATTCAAAACACCACCTTATTCTTGGTG
TCTTTAATTGCTGTGCCTTGTTATTTGGTGATTGTGTTCGCTTTTCAGCGGCCATTTAATCGACTGAATCAAGAGACGAT
GGAAAGCAATGCCATTTTGAGTTCATCTATTATCGAAGACTTGAACGGGATTGAGACGATTAAATCACTGACCGGTGAGA
AAGTCAGTTATGAACGGGTTGACCGTGAATTCGTCACGTATTTGAAAAAGTCGTTCAATTATACAAAAGCTGATCAACTG
CAGCAGGCGATCAAGGGACTGCTGAAGTTGGTTTTGAATGTGGTCGTGCTGTGGATTGGTGCGAGTTTGGTGATGGCTAA
CAAGATGAGTCTAGGACAGATGCTGACGTTCAATGCGTTGTTGGCATATTTCACTAATCCGTTAGAAAGCATCATTAATT
TGCAACCAAAATTGCAAATGGCCAAAGTCGCGAATAACCGGCTGAATGAAGTGTATTTGGTTGAATCGGAGTTTAAAGAA
CAGCGAAGTTTGAATGATCGGCATTTAATTGATGGCGCCATCAATGTGACCGATGTGTCCTTTAAGTATGGTTTTGGGCA
AGATGTTTTGAAACAAATCAACCTTGAAATCCCGGAGAATGCCAAATACACCATTGTCGGCATGAGTGGATCTGGGAAAT
CGACCTTAGCCAAGTTGCTAGTAGGTTTCTATCCAGTGGACACTGGCAAAGGGAAAATCACATTTAATGGGGTTCCCATC
AGTGATGTTGATCTAACAACGTTACGACAATATATCGAGTATGTACCACAAGATCCGTTTATTTTTTCTGGCTCAGTCAT
TGAAAACTTAACGTTGGGTAGCCGTTCGAATATCACTGAAGCTGATATTGAAGCTGCCTGTTCAGTGGCGGAAATTGCTG
GAGATATTTCGAATTTGCCGCAGATATGGCAGACCAAACTTTCTGAAAGCGGCAGTATTTTATCGGGTGGACAAAAGCAG
CGCCTAGCAATTGCCCGCGCGTTATTATCACCGGCAAAAGTGTTGATTTTTGATGAATCGACCAGCAGTTTAGATACGAT
CACCGAGCGGAAAATTGTTGATCGGTTGTTAGCGATGACTGATCGAACCATTATTTTTGTGGCTCATCGGCTAACCATTG
CTGCTAAAACGGAACAGATTGTGGTCATGGATCATGGTGCGATTGTTGAACAAGGAAATCATGCTGAGTTATTGGCCAAA
CAAGGCTATTATGCTCGGTTGGTAAGTGAGTGA

Domains

Predicted by InterproScan.

• ABC transporter (ABC_tran) (510-662)

• Peptidase C39 family (Peptidase_C39) (16-152)

• ABC transporter transmembrane region (ABC_membrane) (180-448)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comA	Streptococcus mitis NCTC 12261	58.774	98.356	0.578
comA	Streptococcus pneumoniae Rx1	58.217	98.356	0.573
comA	Streptococcus pneumoniae D39	58.217	98.356	0.573
comA	Streptococcus pneumoniae R6	58.217	98.356	0.573
comA	Streptococcus mitis SK321	58.078	98.356	0.571
comA	Streptococcus pneumoniae TIGR4	57.799	98.356	0.568
comA	Streptococcus gordonii str. Challis substr. CH1	56.964	98.356	0.56
comA/nlmT	Streptococcus mutans UA159	54.848	98.904	0.542